======= MRPL35 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MRPL35
  * **<color #00a2e8>Official Name</color>**: mitochondrial ribosomal protein L35
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51318|51318]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NZE8|Q9NZE8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MRPL35&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MRPL35|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611841|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ribosomal L35p|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial ribosome|
|mitochondrial large ribosomal subunit|
|mitochondrial translational termination|
|mitochondrial translational elongation|
|translational termination|
|mitochondrial translation|
|translational elongation|
|cellular protein complex disassembly|
|mitochondrial gene expression|
|structural constituent of ribosome|
|protein-containing complex disassembly|
|translation|
|mitochondrial inner membrane|
|cellular component disassembly|
|peptide biosynthetic process|
|amide biosynthetic process|
|peptide metabolic process|
|cellular amide metabolic process|
|mitochondrion|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|1.77|
|[[:results:exp211|AICAR 240μM R05 exp211]]|1.81|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|1.84|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|1.92|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|2.08|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:nars2|NARS2]]|0.523|
|[[:human genes:m:mrps21|MRPS21]]|0.503|
|[[:human genes:m:mars2|MARS2]]|0.491|
|[[:human genes:m:mrps35|MRPS35]]|0.486|
|[[:human genes:c:coa3|COA3]]|0.482|
|[[:human genes:m:mrps6|MRPS6]]|0.473|
|[[:human genes:y:yars2|YARS2]]|0.471|
|[[:human genes:p:pet117|PET117]]|0.47|
|[[:human genes:m:mrps26|MRPS26]]|0.469|
|[[:human genes:e:ears2|EARS2]]|0.463|
|[[:human genes:m:mrps22|MRPS22]]|0.461|
|[[:human genes:g:gfm1|GFM1]]|0.459|
|[[:human genes:v:vars2|VARS2]]|0.458|
|[[:human genes:s:selrc1|SELRC1]]|0.457|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.453|
|[[:human genes:m:mrps34|MRPS34]]|0.453|
|[[:human genes:m:mrps16|MRPS16]]|0.452|
|[[:human genes:m:mrps5|MRPS5]]|0.447|
|[[:human genes:l:lars2|LARS2]]|0.442|
|[[:human genes:t:tars2|TARS2]]|0.44|
|[[:human genes:m:mrpl43|MRPL43]]|0.438|
|[[:human genes:s:sco2|SCO2]]|0.436|
|[[:human genes:m:mrp63|MRP63]]|0.436|
|[[:human genes:m:mrpl21|MRPL21]]|0.435|
|[[:human genes:t:tomm20|TOMM20]]|0.434|
|[[:human genes:m:mrps10|MRPS10]]|0.433|
|[[:human genes:m:mrpl28|MRPL28]]|0.433|
|[[:human genes:d:ddx28|DDX28]]|0.43|
|[[:human genes:t:tefm|TEFM]]|0.43|
|[[:human genes:q:qrsl1|QRSL1]]|0.429|
|[[:human genes:m:mrpl17|MRPL17]]|0.428|
|[[:human genes:t:tfb1m|TFB1M]]|0.425|
|[[:human genes:r:rpusd4|RPUSD4]]|0.425|
|[[:human genes:d:dars2|DARS2]]|0.424|
|[[:human genes:c:coa6|COA6]]|0.423|
|[[:human genes:p:pet112|PET112]]|0.421|
|[[:human genes:f:ftsj2|FTSJ2]]|0.421|
|[[:human genes:d:dap3|DAP3]]|0.42|
|[[:human genes:n:ndufs2|NDUFS2]]|0.418|
|[[:human genes:m:mrpl9|MRPL9]]|0.415|
|[[:human genes:p:ptcd3|PTCD3]]|0.415|
|[[:human genes:m:mrpl47|MRPL47]]|0.413|
|[[:human genes:m:mrpl44|MRPL44]]|0.412|
|[[:human genes:m:mrpl3|MRPL3]]|0.412|
|[[:human genes:m:mterfd1|MTERFD1]]|0.411|
|[[:human genes:a:aifm1|AIFM1]]|0.411|
|[[:human genes:m:mrps14|MRPS14]]|0.41|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.41|
|[[:human genes:c:cars2|CARS2]]|0.409|
|[[:human genes:a:aars2|AARS2]]|0.409|
|[[:human genes:m:mrpl20|MRPL20]]|0.408|
|[[:human genes:m:mrps18a|MRPS18A]]|0.406|
|[[:human genes:c:cox16|COX16]]|0.405|
|[[:human genes:m:mtg2|MTG2]]|0.404|
|[[:human genes:p:pars2|PARS2]]|0.404|
|[[:human genes:p:polg2|POLG2]]|0.403|
|[[:human genes:m:mrpl55|MRPL55]]|0.402|
|[[:human genes:h:hars2|HARS2]]|0.402|
|[[:human genes:n:ndufa3|NDUFA3]]|0.401|
|[[:human genes:p:polrmt|POLRMT]]|0.401|
|[[:human genes:r:rars2|RARS2]]|0.401|
|[[:human genes:n:ndufc2|NDUFC2]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 32/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|0/28|
|bone|1/26|
|breast|3/33|
|central nervous system|2/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|2/21|
|liver|1/20|
|lung|5/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|2/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|2/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1394
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.92 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MRPL35 Expression in NALM6 Cells: 5.92'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>