======= MRPL38 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MRPL38
  * **<color #00a2e8>Official Name</color>**: mitochondrial ribosomal protein L38
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=64978|64978]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96DV4|Q96DV4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MRPL38&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MRPL38|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611844|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PBP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial large ribosomal subunit|
|mitochondrial translational elongation|
|mitochondrial translational termination|
|translational termination|
|mitochondrial translation|
|translational elongation|
|cellular protein complex disassembly|
|mitochondrial gene expression|
|protein-containing complex disassembly|
|translation|
|mitochondrial inner membrane|
|cellular component disassembly|
|peptide biosynthetic process|
|amide biosynthetic process|
|peptide metabolic process|
|cellular amide metabolic process|
|mitochondrion|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|-2.73|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|-1.98|
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|-1.92|
|[[:results:exp135|MS023 7μM R03 exp135]]|-1.92|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|-1.78|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|1.71|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|1.74|
|[[:results:exp504|MK2206 4μM R08 exp504]]|1.75|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|1.92|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|2.05|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|2.09|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|2.12|
|[[:results:exp116|AICAR 240μM R03 exp116]]|2.14|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|2.17|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tfam|TFAM]]|0.499|
|[[:human genes:m:mrps25|MRPS25]]|0.475|
|[[:human genes:n:ndufa3|NDUFA3]]|0.469|
|[[:human genes:m:mrp63|MRP63]]|0.468|
|[[:human genes:n:nars2|NARS2]]|0.461|
|[[:human genes:m:mrpl12|MRPL12]]|0.458|
|[[:human genes:m:mrpl3|MRPL3]]|0.456|
|[[:human genes:m:mrpl45|MRPL45]]|0.455|
|[[:human genes:t:tufm|TUFM]]|0.454|
|[[:human genes:g:gfm1|GFM1]]|0.454|
|[[:human genes:m:mrpl23|MRPL23]]|0.453|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.452|
|[[:human genes:m:mrpl13|MRPL13]]|0.442|
|[[:human genes:m:mrpl21|MRPL21]]|0.438|
|[[:human genes:m:mrps24|MRPS24]]|0.437|
|[[:human genes:q:qrsl1|QRSL1]]|0.436|
|[[:human genes:m:mrps9|MRPS9]]|0.435|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.433|
|[[:human genes:f:fars2|FARS2]]|0.43|
|[[:human genes:f:ftsj2|FTSJ2]]|0.429|
|[[:human genes:d:dap3|DAP3]]|0.428|
|[[:human genes:v:vars2|VARS2]]|0.427|
|[[:human genes:s:selrc1|SELRC1]]|0.421|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.42|
|[[:human genes:m:mrps35|MRPS35]]|0.42|
|[[:human genes:r:rars2|RARS2]]|0.419|
|[[:human genes:m:mtg1|MTG1]]|0.418|
|[[:human genes:y:yars2|YARS2]]|0.418|
|[[:human genes:n:ndufs2|NDUFS2]]|0.417|
|[[:human genes:m:mrpl32|MRPL32]]|0.415|
|[[:human genes:b:bcs1l|BCS1L]]|0.414|
|[[:human genes:m:mrps22|MRPS22]]|0.413|
|[[:human genes:a:acad9|ACAD9]]|0.411|
|[[:human genes:p:polg2|POLG2]]|0.41|
|[[:human genes:m:mrps18a|MRPS18A]]|0.408|
|[[:human genes:m:mrpl43|MRPL43]]|0.407|
|[[:human genes:t:tars2|TARS2]]|0.407|
|[[:human genes:s:sars2|SARS2]]|0.406|
|[[:human genes:l:lars2|LARS2]]|0.404|
|[[:human genes:m:mrps5|MRPS5]]|0.404|
|[[:human genes:c:cox16|COX16]]|0.404|
|[[:human genes:m:mrps26|MRPS26]]|0.403|
|[[:human genes:c:cox11|COX11]]|0.402|
|[[:human genes:m:mtpap|MTPAP]]|0.402|
|[[:human genes:n:ndufs7|NDUFS7]]|0.401|
|[[:human genes:n:ndufb9|NDUFB9]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 134/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|5/28|
|blood|2/28|
|bone|4/26|
|breast|7/33|
|central nervous system|7/56|
|cervix|2/4|
|colorectal|5/17|
|esophagus|5/13|
|fibroblast|0/1|
|gastric|4/16|
|kidney|2/21|
|liver|4/20|
|lung|16/75|
|lymphocyte|1/16|
|ovary|5/26|
|pancreas|3/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|2/24|
|soft tissue|2/9|
|thyroid|0/2|
|upper aerodigestive|6/22|
|urinary tract|5/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 681
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.33 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MRPL38 Expression in NALM6 Cells: 5.33'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>