======= MRPL43 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MRPL43
  * **<color #00a2e8>Official Name</color>**: mitochondrial ribosomal protein L43
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=84545|84545]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8N983|Q8N983]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MRPL43&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MRPL43|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611848|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. This gene and the gene for a semaphorin class 4 protein (SEMA4G) overlap at map location 10q24.31 and are transcribed in opposite directions. Sequence analysis identified multiple transcript variants encoding at least four different protein isoforms. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|L51 S25 CI-B8|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial ribosome|
|mitochondrial large ribosomal subunit|
|mitochondrial translational elongation|
|mitochondrial translational termination|
|translational termination|
|mitochondrial translation|
|translational elongation|
|cellular protein complex disassembly|
|mitochondrial gene expression|
|structural constituent of ribosome|
|protein-containing complex disassembly|
|translation|
|mitochondrial inner membrane|
|cellular component disassembly|
|peptide biosynthetic process|
|amide biosynthetic process|
|peptide metabolic process|
|cellular amide metabolic process|
|mitochondrion|
|RNA binding|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp42|BI-6727 0.001μM R01 exp42]]|-1.95|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|1.7|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|1.77|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|1.82|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|1.83|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|1.85|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|2.02|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|2.82|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hsd17b10|HSD17B10]]|0.573|
|[[:human genes:n:nars2|NARS2]]|0.564|
|[[:human genes:m:mrpl21|MRPL21]]|0.55|
|[[:human genes:m:mrps21|MRPS21]]|0.547|
|[[:human genes:q:qrsl1|QRSL1]]|0.543|
|[[:human genes:y:yars2|YARS2]]|0.539|
|[[:human genes:l:lars2|LARS2]]|0.533|
|[[:human genes:r:rars2|RARS2]]|0.531|
|[[:human genes:m:mrps16|MRPS16]]|0.529|
|[[:human genes:m:mrpl23|MRPL23]]|0.528|
|[[:human genes:t:tars2|TARS2]]|0.528|
|[[:human genes:g:gfm1|GFM1]]|0.523|
|[[:human genes:p:pet112|PET112]]|0.523|
|[[:human genes:f:fastkd5|FASTKD5]]|0.52|
|[[:human genes:m:mtg2|MTG2]]|0.52|
|[[:human genes:c:coa3|COA3]]|0.52|
|[[:human genes:m:mrps6|MRPS6]]|0.513|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.512|
|[[:human genes:d:dars2|DARS2]]|0.51|
|[[:human genes:h:hars2|HARS2]]|0.509|
|[[:human genes:n:ndufb11|NDUFB11]]|0.508|
|[[:human genes:d:dap3|DAP3]]|0.507|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.505|
|[[:human genes:n:ndufs2|NDUFS2]]|0.505|
|[[:human genes:e:ears2|EARS2]]|0.504|
|[[:human genes:m:mrpl45|MRPL45]]|0.504|
|[[:human genes:n:ndufa3|NDUFA3]]|0.5|
|[[:human genes:p:pars2|PARS2]]|0.5|
|[[:human genes:a:acad9|ACAD9]]|0.499|
|[[:human genes:p:pet117|PET117]]|0.498|
|[[:human genes:m:mrp63|MRP63]]|0.497|
|[[:human genes:v:vars2|VARS2]]|0.496|
|[[:human genes:n:ndufa1|NDUFA1]]|0.495|
|[[:human genes:m:mrps34|MRPS34]]|0.492|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.491|
|[[:human genes:m:mrps14|MRPS14]]|0.49|
|[[:human genes:n:ndufc2|NDUFC2]]|0.485|
|[[:human genes:c:c10orf2|C10orf2]]|0.485|
|[[:human genes:m:mrpl3|MRPL3]]|0.485|
|[[:human genes:r:rpusd4|RPUSD4]]|0.482|
|[[:human genes:s:selrc1|SELRC1]]|0.481|
|[[:human genes:m:mrps18a|MRPS18A]]|0.481|
|[[:human genes:m:malsu1|MALSU1]]|0.48|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.479|
|[[:human genes:m:mrps22|MRPS22]]|0.479|
|[[:human genes:m:mrps5|MRPS5]]|0.479|
|[[:human genes:m:mrps9|MRPS9]]|0.479|
|[[:human genes:t:tufm|TUFM]]|0.479|
|[[:human genes:n:ndufb4|NDUFB4]]|0.478|
|[[:human genes:m:mars2|MARS2]]|0.474|
|[[:human genes:c:cox11|COX11]]|0.472|
|[[:human genes:s:sco2|SCO2]]|0.471|
|[[:human genes:n:ndufa2|NDUFA2]]|0.471|
|[[:human genes:m:mrps25|MRPS25]]|0.47|
|[[:human genes:r:rpusd3|RPUSD3]]|0.47|
|[[:human genes:f:ftsj2|FTSJ2]]|0.469|
|[[:human genes:m:mrps26|MRPS26]]|0.467|
|[[:human genes:m:mrpl11|MRPL11]]|0.466|
|[[:human genes:m:mrpl53|MRPL53]]|0.465|
|[[:human genes:c:chchd1|CHCHD1]]|0.464|
|[[:human genes:m:mrps7|MRPS7]]|0.464|
|[[:human genes:s:sars2|SARS2]]|0.463|
|[[:human genes:n:ndufa11|NDUFA11]]|0.463|
|[[:human genes:m:mrpl12|MRPL12]]|0.46|
|[[:human genes:n:ndufa10|NDUFA10]]|0.46|
|[[:human genes:i:iba57|IBA57]]|0.46|
|[[:human genes:m:mrps27|MRPS27]]|0.459|
|[[:human genes:t:tfb1m|TFB1M]]|0.459|
|[[:human genes:h:hmgxb3|HMGXB3]]|0.457|
|[[:human genes:c:cox16|COX16]]|0.456|
|[[:human genes:a:aars2|AARS2]]|0.455|
|[[:human genes:m:mettl17|METTL17]]|0.454|
|[[:human genes:m:mtif2|MTIF2]]|0.453|
|[[:human genes:g:grsf1|GRSF1]]|0.452|
|[[:human genes:e:eral1|ERAL1]]|0.452|
|[[:human genes:m:mrps35|MRPS35]]|0.451|
|[[:human genes:c:coq7|COQ7]]|0.451|
|[[:human genes:m:mrps24|MRPS24]]|0.451|
|[[:human genes:m:mrpl37|MRPL37]]|0.45|
|[[:human genes:m:mrpl20|MRPL20]]|0.45|
|[[:human genes:m:mrpl15|MRPL15]]|0.45|
|[[:human genes:m:mrps10|MRPS10]]|0.447|
|[[:human genes:m:mrpl47|MRPL47]]|0.446|
|[[:human genes:p:polg2|POLG2]]|0.445|
|[[:human genes:f:fars2|FARS2]]|0.445|
|[[:human genes:r:rbfa|RBFA]]|0.445|
|[[:human genes:n:ndufb9|NDUFB9]]|0.445|
|[[:human genes:n:nubpl|NUBPL]]|0.444|
|[[:human genes:t:trub2|TRUB2]]|0.441|
|[[:human genes:c:c12orf65|C12orf65]]|0.441|
|[[:human genes:m:mcat|MCAT]]|0.441|
|[[:human genes:g:gtpbp8|GTPBP8]]|0.44|
|[[:human genes:m:mrpl17|MRPL17]]|0.438|
|[[:human genes:m:mrpl35|MRPL35]]|0.438|
|[[:human genes:n:ndufb5|NDUFB5]]|0.438|
|[[:human genes:m:mrps18b|MRPS18B]]|0.437|
|[[:human genes:t:tefm|TEFM]]|0.436|
|[[:human genes:c:coa6|COA6]]|0.435|
|[[:human genes:m:mtg1|MTG1]]|0.434|
|[[:human genes:m:mrpl55|MRPL55]]|0.434|
|[[:human genes:f:fastkd2|FASTKD2]]|0.433|
|[[:human genes:m:mterfd1|MTERFD1]]|0.432|
|[[:human genes:m:mrpl44|MRPL44]]|0.432|
|[[:human genes:s:slc25a3|SLC25A3]]|0.43|
|[[:human genes:c:cox7b|COX7B]]|0.429|
|[[:human genes:m:mrps2|MRPS2]]|0.427|
|[[:human genes:n:nsun4|NSUN4]]|0.426|
|[[:human genes:m:mrps12|MRPS12]]|0.426|
|[[:human genes:b:bcs1l|BCS1L]]|0.426|
|[[:human genes:l:lrpprc|LRPPRC]]|0.425|
|[[:human genes:w:wbscr16|WBSCR16]]|0.425|
|[[:human genes:r:rnmtl1|RNMTL1]]|0.425|
|[[:human genes:d:ddx28|DDX28]]|0.424|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.424|
|[[:human genes:m:mto1|MTO1]]|0.423|
|[[:human genes:m:mrpl49|MRPL49]]|0.422|
|[[:human genes:t:tomm20|TOMM20]]|0.421|
|[[:human genes:c:cox19|COX19]]|0.421|
|[[:human genes:m:mrpl42|MRPL42]]|0.421|
|[[:human genes:m:mipep|MIPEP]]|0.421|
|[[:human genes:n:ndufv1|NDUFV1]]|0.42|
|[[:human genes:g:gfm2|GFM2]]|0.42|
|[[:human genes:t:tfam|TFAM]]|0.418|
|[[:human genes:n:ndufa13|NDUFA13]]|0.418|
|[[:human genes:u:uqcrc1|UQCRC1]]|0.417|
|[[:human genes:c:cox6b1|COX6B1]]|0.415|
|[[:human genes:c:coq2|COQ2]]|0.413|
|[[:human genes:a:aifm1|AIFM1]]|0.411|
|[[:human genes:m:mrps33|MRPS33]]|0.411|
|[[:human genes:m:mrpl13|MRPL13]]|0.411|
|[[:human genes:n:ndufa8|NDUFA8]]|0.41|
|[[:human genes:t:tomm40|TOMM40]]|0.41|
|[[:human genes:m:mrpl22|MRPL22]]|0.409|
|[[:human genes:c:cars2|CARS2]]|0.408|
|[[:human genes:n:ndufb3|NDUFB3]]|0.407|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.407|
|[[:human genes:m:mrpl38|MRPL38]]|0.407|
|[[:human genes:p:ptcd3|PTCD3]]|0.406|
|[[:human genes:m:mrps28|MRPS28]]|0.406|
|[[:human genes:m:mrpl24|MRPL24]]|0.405|
|[[:human genes:p:polrmt|POLRMT]]|0.405|
|[[:human genes:m:mrpl4|MRPL4]]|0.404|
|[[:human genes:s:ssbp1|SSBP1]]|0.402|
|[[:human genes:n:ndufaf1|NDUFAF1]]|0.4|
|[[:human genes:m:mtpap|MTPAP]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 291/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|10/28|
|blood|13/28|
|bone|11/26|
|breast|21/33|
|central nervous system|19/56|
|cervix|2/4|
|colorectal|6/17|
|esophagus|7/13|
|fibroblast|0/1|
|gastric|5/16|
|kidney|8/21|
|liver|12/20|
|lung|28/75|
|lymphocyte|9/16|
|ovary|3/26|
|pancreas|6/24|
|peripheral nervous system|4/16|
|plasma cell|3/15|
|prostate|0/1|
|skin|13/24|
|soft tissue|3/9|
|thyroid|0/2|
|upper aerodigestive|11/22|
|urinary tract|13/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 750
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.87 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MRPL43 Expression in NALM6 Cells: 4.87'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>