======= MRPS28 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MRPS28
  * **<color #00a2e8>Official Name</color>**: mitochondrial ribosomal protein S28
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=28957|28957]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y2Q9|Q9Y2Q9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MRPS28&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MRPS28|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611990|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|MRP-S35|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial small ribosomal subunit|
|mitochondrial translational elongation|
|mitochondrial translational termination|
|translational termination|
|mitochondrial translation|
|translational elongation|
|cellular protein complex disassembly|
|mitochondrial gene expression|
|protein-containing complex disassembly|
|translation|
|mitochondrial inner membrane|
|cellular component disassembly|
|peptide biosynthetic process|
|amide biosynthetic process|
|peptide metabolic process|
|cellular amide metabolic process|
|mitochondrion|
|RNA binding|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp426|FBS-Wisent 0.1 R07 exp426]]|1.79|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|1.85|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|2.18|
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|2.22|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|2.29|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:mrps21|MRPS21]]|0.541|
|[[:human genes:m:mrpl21|MRPL21]]|0.499|
|[[:human genes:n:ndufa11|NDUFA11]]|0.494|
|[[:human genes:n:nars2|NARS2]]|0.491|
|[[:human genes:e:ears2|EARS2]]|0.478|
|[[:human genes:l:lars2|LARS2]]|0.476|
|[[:human genes:g:gfm1|GFM1]]|0.476|
|[[:human genes:h:hars2|HARS2]]|0.475|
|[[:human genes:m:mrpl45|MRPL45]]|0.472|
|[[:human genes:m:mrpl23|MRPL23]]|0.459|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.458|
|[[:human genes:s:selrc1|SELRC1]]|0.449|
|[[:human genes:c:cox16|COX16]]|0.447|
|[[:human genes:p:polg2|POLG2]]|0.438|
|[[:human genes:m:mrpl53|MRPL53]]|0.436|
|[[:human genes:d:dap3|DAP3]]|0.434|
|[[:human genes:f:fastkd5|FASTKD5]]|0.428|
|[[:human genes:a:aars2|AARS2]]|0.428|
|[[:human genes:n:ndufa3|NDUFA3]]|0.427|
|[[:human genes:m:mtg2|MTG2]]|0.425|
|[[:human genes:v:vars2|VARS2]]|0.425|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.423|
|[[:human genes:r:rpusd3|RPUSD3]]|0.422|
|[[:human genes:t:tars2|TARS2]]|0.422|
|[[:human genes:y:yars2|YARS2]]|0.418|
|[[:human genes:f:fars2|FARS2]]|0.418|
|[[:human genes:m:mrps23|MRPS23]]|0.414|
|[[:human genes:a:acad9|ACAD9]]|0.414|
|[[:human genes:p:pet112|PET112]]|0.414|
|[[:human genes:m:mrpl51|MRPL51]]|0.413|
|[[:human genes:c:coa3|COA3]]|0.413|
|[[:human genes:c:clpp|CLPP]]|0.412|
|[[:human genes:m:mrps33|MRPS33]]|0.41|
|[[:human genes:m:mrpl44|MRPL44]]|0.409|
|[[:human genes:t:tmem261|TMEM261]]|0.409|
|[[:human genes:m:mrpl43|MRPL43]]|0.406|
|[[:human genes:u:uqcrc1|UQCRC1]]|0.406|
|[[:human genes:n:ndufc2|NDUFC2]]|0.405|
|[[:human genes:m:mettl17|METTL17]]|0.404|
|[[:human genes:p:pars2|PARS2]]|0.403|
|[[:human genes:m:mrps6|MRPS6]]|0.403|
|[[:human genes:m:malsu1|MALSU1]]|0.403|
|[[:human genes:n:ndufb6|NDUFB6]]|0.401|
|[[:human genes:m:mrpl3|MRPL3]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 6/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|2/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|1/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2071
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.92 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MRPS28 Expression in NALM6 Cells: 4.92'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>