======= MTCH2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MTCH2
  * **<color #00a2e8>Official Name</color>**: mitochondrial carrier 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23788|23788]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y6C9|Q9Y6C9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MTCH2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MTCH2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/613221|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  The substrate transported is not yet known. Induces mitochondrial depolarization.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Mito carr|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein localization to mitochondrion|
|mitochondrial inner membrane|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|positive regulation of cell death|
|protein localization to organelle|
|mitochondrion|
|regulation of apoptotic process|
|regulation of programmed cell death|
|cellular protein localization|
|cellular macromolecule localization|
|regulation of cell death|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp19|Etoposide 1μM R00 exp19]]|-3.1|
|[[:results:exp275|Citral 75μM R06 exp275]]|-2.84|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|-2.46|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|-2.45|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|-2.44|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|-2.35|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|-2.28|
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|-2.19|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|-2.19|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|-2.14|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|-2.11|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|-2|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|-1.94|
|[[:results:exp362|GSK-J4 1μM R07 exp362]]|-1.93|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|-1.93|
|[[:results:exp401|SNS-032 25μM R07 exp401]]|-1.9|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|-1.9|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|-1.9|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|-1.85|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|-1.84|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|-1.7|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|-1.7|
|[[:results:exp530|Thioridazine 5μM R08 exp530]]|1.76|
|[[:results:exp107|UMK57 0.6μM R03 exp107]]|1.76|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|1.89|
|[[:results:exp461|BS-181 20μM R08 exp461]]|2|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|2.14|
|[[:results:exp143|Phenformin 20μM R03 exp143]]|2.43|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:atp6v1b2|ATP6V1B2]]|0.492|
|[[:human genes:t:tomm70a|TOMM70A]]|0.464|
|[[:human genes:p:psmb4|PSMB4]]|0.464|
|[[:human genes:r:rrp7a|RRP7A]]|0.456|
|[[:human genes:s:sh3bp1|SH3BP1]]|0.455|
|[[:human genes:d:dhx38|DHX38]]|0.454|
|[[:human genes:v:vps28|VPS28]]|0.453|
|[[:human genes:r:rpl35|RPL35]]|0.451|
|[[:human genes:p:psmb2|PSMB2]]|0.449|
|[[:human genes:p:prpf19|PRPF19]]|0.447|
|[[:human genes:k:klhl12|KLHL12]]|0.446|
|[[:human genes:m:mbtd1|MBTD1]]|0.444|
|[[:human genes:m:mul1|MUL1]]|0.444|
|[[:human genes:p:polr2a|POLR2A]]|0.443|
|[[:human genes:g:gid4|GID4]]|0.442|
|[[:human genes:z:zfand5|ZFAND5]]|0.439|
|[[:human genes:d:dnm2|DNM2]]|0.438|
|[[:human genes:r:ruvbl2|RUVBL2]]|0.438|
|[[:human genes:r:rps19bp1|RPS19BP1]]|0.436|
|[[:human genes:e:exosc6|EXOSC6]]|0.434|
|[[:human genes:r:rrp15|RRP15]]|0.432|
|[[:human genes:u:ube4a|UBE4A]]|0.427|
|[[:human genes:b:brd2|BRD2]]|0.427|
|[[:human genes:s:skiv2l2|SKIV2L2]]|0.426|
|[[:human genes:u:usp5|USP5]]|0.422|
|[[:human genes:a:aatf|AATF]]|0.421|
|[[:human genes:n:narfl|NARFL]]|0.421|
|[[:human genes:t:tceb3c|TCEB3C]]|0.42|
|[[:human genes:p:prim1|PRIM1]]|0.418|
|[[:human genes:i:ik|IK]]|0.417|
|[[:human genes:c:chd4|CHD4]]|0.415|
|[[:human genes:c:ccna2|CCNA2]]|0.413|
|[[:human genes:s:sf3b3|SF3B3]]|0.41|
|[[:human genes:e:exosc9|EXOSC9]]|0.41|
|[[:human genes:r:rnpc3|RNPC3]]|0.41|
|[[:human genes:s:snip1|SNIP1]]|0.408|
|[[:human genes:t:ticrr|TICRR]]|0.408|
|[[:human genes:t:tsg101|TSG101]]|0.406|
|[[:human genes:k:krt78|KRT78]]|0.406|
|[[:human genes:m:med14|MED14]]|0.406|
|[[:human genes:n:nol12|NOL12]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 3/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2070
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.62 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MTCH2 Expression in NALM6 Cells: 6.62'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>