======= MTERFD1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MTERF3
  * **<color #00a2e8>Official Name</color>**: mitochondrial transcription termination factor 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51001|51001]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96E29|Q96E29]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MTERFD1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MTERFD1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616930|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Binds promoter DNA and regulates initiation of transcription (PubMed:17662942). Required for normal mitochondrial transcription and translation, and for normal assembly of mitochondrial respiratory complexes. Required for normal mitochondrial function (By similarity). Maintains 16S rRNA levels and functions in mitochondrial ribosome assembly by regulating the biogenesis of the 39S ribosomal subunit (By similarity). {ECO:0000250|UniProtKB:Q8R3J4, ECO:0000269|PubMed:17662942}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|mTERF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial ribosome assembly|
|mitochondrial transcription|
|mitochondrial RNA metabolic process|
|ribosome assembly|
|double-stranded DNA binding|
|mitochondrial translation|
|mitochondrial gene expression|
|macroautophagy|
|mitochondrial outer membrane|
|transcription regulatory region DNA binding|
|ribonucleoprotein complex assembly|
|ribonucleoprotein complex subunit organization|
|process utilizing autophagic mechanism|
|autophagy|
|ribosome biogenesis|
|translation|
|peptide biosynthetic process|
|ribonucleoprotein complex biogenesis|
|amide biosynthetic process|
|peptide metabolic process|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|organelle assembly|
|cellular amide metabolic process|
|cellular protein-containing complex assembly|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|mitochondrion|
|organic cyclic compound biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|organonitrogen compound biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|protein-containing complex assembly|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|macromolecule biosynthetic process|
|cellular catabolic process|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp90|WYE-354 6μM R02 exp90]]|1.71|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|1.73|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|1.84|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|1.88|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|1.98|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|2.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:nars2|NARS2]]|0.573|
|[[:human genes:p:pet112|PET112]]|0.559|
|[[:human genes:r:rbfa|RBFA]]|0.545|
|[[:human genes:a:acad9|ACAD9]]|0.544|
|[[:human genes:w:wbscr16|WBSCR16]]|0.542|
|[[:human genes:f:ftsj2|FTSJ2]]|0.538|
|[[:human genes:n:ndufa1|NDUFA1]]|0.533|
|[[:human genes:d:dap3|DAP3]]|0.53|
|[[:human genes:n:ndufb9|NDUFB9]]|0.528|
|[[:human genes:r:rpusd3|RPUSD3]]|0.521|
|[[:human genes:l:lars2|LARS2]]|0.52|
|[[:human genes:t:tfb1m|TFB1M]]|0.518|
|[[:human genes:c:coa3|COA3]]|0.516|
|[[:human genes:m:mrps27|MRPS27]]|0.515|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.514|
|[[:human genes:g:gfm1|GFM1]]|0.514|
|[[:human genes:n:ndufc2|NDUFC2]]|0.513|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.513|
|[[:human genes:m:mrps21|MRPS21]]|0.513|
|[[:human genes:f:fastkd2|FASTKD2]]|0.512|
|[[:human genes:n:ndufs2|NDUFS2]]|0.51|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.509|
|[[:human genes:m:mrps6|MRPS6]]|0.507|
|[[:human genes:g:gfm2|GFM2]]|0.506|
|[[:human genes:n:ndufaf6|NDUFAF6]]|0.506|
|[[:human genes:m:mrpl21|MRPL21]]|0.505|
|[[:human genes:n:ndufb11|NDUFB11]]|0.504|
|[[:human genes:m:mrpl47|MRPL47]]|0.5|
|[[:human genes:m:mto1|MTO1]]|0.5|
|[[:human genes:q:qrsl1|QRSL1]]|0.498|
|[[:human genes:m:mrpl45|MRPL45]]|0.497|
|[[:human genes:m:mars2|MARS2]]|0.497|
|[[:human genes:m:mrpl3|MRPL3]]|0.496|
|[[:human genes:n:nubpl|NUBPL]]|0.495|
|[[:human genes:m:mrps25|MRPS25]]|0.494|
|[[:human genes:n:ndufa3|NDUFA3]]|0.492|
|[[:human genes:d:ddx28|DDX28]]|0.492|
|[[:human genes:m:malsu1|MALSU1]]|0.488|
|[[:human genes:r:rars2|RARS2]]|0.488|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.486|
|[[:human genes:m:mettl17|METTL17]]|0.482|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.482|
|[[:human genes:c:cars2|CARS2]]|0.481|
|[[:human genes:y:yars2|YARS2]]|0.479|
|[[:human genes:m:mrpl53|MRPL53]]|0.479|
|[[:human genes:g:grsf1|GRSF1]]|0.478|
|[[:human genes:d:dars2|DARS2]]|0.478|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.477|
|[[:human genes:m:mrps5|MRPS5]]|0.474|
|[[:human genes:p:pars2|PARS2]]|0.473|
|[[:human genes:c:chchd1|CHCHD1]]|0.472|
|[[:human genes:r:rpusd4|RPUSD4]]|0.472|
|[[:human genes:n:ndufa2|NDUFA2]]|0.47|
|[[:human genes:m:mrps14|MRPS14]]|0.467|
|[[:human genes:m:mrp63|MRP63]]|0.465|
|[[:human genes:p:pet117|PET117]]|0.465|
|[[:human genes:n:ndufaf1|NDUFAF1]]|0.463|
|[[:human genes:s:selrc1|SELRC1]]|0.463|
|[[:human genes:e:ears2|EARS2]]|0.462|
|[[:human genes:m:mrpl23|MRPL23]]|0.462|
|[[:human genes:n:ndufa11|NDUFA11]]|0.459|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.457|
|[[:human genes:m:mtif2|MTIF2]]|0.456|
|[[:human genes:n:ndufs5|NDUFS5]]|0.456|
|[[:human genes:m:mrps35|MRPS35]]|0.455|
|[[:human genes:c:clpp|CLPP]]|0.45|
|[[:human genes:n:ndufaf5|NDUFAF5]]|0.448|
|[[:human genes:n:ndufa10|NDUFA10]]|0.448|
|[[:human genes:t:tars2|TARS2]]|0.448|
|[[:human genes:n:ndufv1|NDUFV1]]|0.447|
|[[:human genes:m:mrpl20|MRPL20]]|0.447|
|[[:human genes:m:mrpl44|MRPL44]]|0.446|
|[[:human genes:a:atp5sl|ATP5SL]]|0.443|
|[[:human genes:m:mrps26|MRPS26]]|0.443|
|[[:human genes:m:mrpl39|MRPL39]]|0.443|
|[[:human genes:m:mrpl4|MRPL4]]|0.44|
|[[:human genes:m:mtg1|MTG1]]|0.439|
|[[:human genes:t:tufm|TUFM]]|0.439|
|[[:human genes:t:trub2|TRUB2]]|0.439|
|[[:human genes:n:ndufs1|NDUFS1]]|0.439|
|[[:human genes:h:hars2|HARS2]]|0.437|
|[[:human genes:c:coq7|COQ7]]|0.436|
|[[:human genes:a:atp5c1|ATP5C1]]|0.433|
|[[:human genes:m:mrps10|MRPS10]]|0.433|
|[[:human genes:b:bcs1l|BCS1L]]|0.432|
|[[:human genes:s:sars2|SARS2]]|0.432|
|[[:human genes:m:mrpl43|MRPL43]]|0.432|
|[[:human genes:a:aars2|AARS2]]|0.429|
|[[:human genes:v:vars2|VARS2]]|0.429|
|[[:human genes:c:coa6|COA6]]|0.428|
|[[:human genes:m:mrpl13|MRPL13]]|0.428|
|[[:human genes:m:mrpl15|MRPL15]]|0.428|
|[[:human genes:c:cox16|COX16]]|0.427|
|[[:human genes:m:mrps9|MRPS9]]|0.426|
|[[:human genes:m:mrps16|MRPS16]]|0.426|
|[[:human genes:x:xpnpep3|XPNPEP3]]|0.425|
|[[:human genes:g:gtpbp6|GTPBP6]]|0.423|
|[[:human genes:m:mrps34|MRPS34]]|0.423|
|[[:human genes:m:mrpl42|MRPL42]]|0.423|
|[[:human genes:s:slc25a3|SLC25A3]]|0.423|
|[[:human genes:t:tsfm|TSFM]]|0.422|
|[[:human genes:p:polrmt|POLRMT]]|0.421|
|[[:human genes:f:fars2|FARS2]]|0.421|
|[[:human genes:m:mcat|MCAT]]|0.42|
|[[:human genes:p:pnpt1|PNPT1]]|0.417|
|[[:human genes:s:ssbp1|SSBP1]]|0.417|
|[[:human genes:p:ptcd3|PTCD3]]|0.417|
|[[:human genes:n:ndufs8|NDUFS8]]|0.416|
|[[:human genes:e:eral1|ERAL1]]|0.416|
|[[:human genes:m:mrpl49|MRPL49]]|0.415|
|[[:human genes:c:cox7b|COX7B]]|0.415|
|[[:human genes:n:ndufb6|NDUFB6]]|0.412|
|[[:human genes:m:mrpl35|MRPL35]]|0.411|
|[[:human genes:r:rnmtl1|RNMTL1]]|0.41|
|[[:human genes:c:cox11|COX11]]|0.41|
|[[:human genes:m:mrps12|MRPS12]]|0.408|
|[[:human genes:n:ndufb4|NDUFB4]]|0.407|
|[[:human genes:s:sco2|SCO2]]|0.407|
|[[:human genes:m:mrps22|MRPS22]]|0.406|
|[[:human genes:h:hmgxb3|HMGXB3]]|0.405|
|[[:human genes:m:mrpl33|MRPL33]]|0.405|
|[[:human genes:n:ndufs3|NDUFS3]]|0.404|
|[[:human genes:p:polg2|POLG2]]|0.404|
|[[:human genes:w:wars2|WARS2]]|0.404|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.401|
|[[:human genes:c:coq2|COQ2]]|0.4|
|[[:human genes:n:ndufb2|NDUFB2]]|0.4|
|[[:human genes:i:iba57|IBA57]]|0.4|
|[[:human genes:m:mterfd2|MTERFD2]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1128
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.84 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MTERFD1 Expression in NALM6 Cells: 4.84'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>