======= MTSS1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MTSS1
  * **<color #00a2e8>Official Name</color>**: MTSS I-BAR domain containing 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9788|9788]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O43312|O43312]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MTSS1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MTSS1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608486|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May be related to cancer progression or tumor metastasis in a variety of organ sites, most likely through an interaction with the actin cytoskeleton.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|IMD|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|nephron tubule epithelial cell differentiation|
|epithelial cell proliferation involved in renal tubule morphogenesis|
|microspike assembly|
|glomerulus morphogenesis|
|cellular response to fluid shear stress|
|actin monomer binding|
|epithelial cell differentiation involved in kidney development|
|response to fluid shear stress|
|cell differentiation involved in kidney development|
|glomerulus development|
|endocytic vesicle|
|renal tubule morphogenesis|
|nephron tubule development|
|renal tubule development|
|epithelial cell proliferation|
|ruffle|
|plasma membrane organization|
|nephron epithelium development|
|negative regulation of epithelial cell proliferation|
|nephron development|
|kidney epithelium development|
|actin cytoskeleton|
|kidney development|
|renal system development|
|epithelial tube morphogenesis|
|urogenital system development|
|regulation of epithelial cell proliferation|
|signaling receptor binding|
|endomembrane system organization|
|morphogenesis of an epithelium|
|plasma membrane bounded cell projection assembly|
|cell projection assembly|
|actin cytoskeleton organization|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|cell population proliferation|
|tissue morphogenesis|
|actin filament-based process|
|tube morphogenesis|
|negative regulation of cell population proliferation|
|epithelial cell differentiation|
|enzyme linked receptor protein signaling pathway|
|tube development|
|membrane organization|
|cell adhesion|
|biological adhesion|
|identical protein binding|
|cytoskeleton organization|
|epithelium development|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|regulation of cell population proliferation|
|cellular response to stress|
|tissue development|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp34|Rotenone 20μM R00 exp34]]|-1.89|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|-1.88|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|2.19|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5490
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.83 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MTSS1 Expression in NALM6 Cells: 2.83'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>