======= MYC =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MYC
  * **<color #00a2e8>Official Name</color>**: MYC proto-oncogene, bHLH transcription factor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4609|4609]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P01106|P01106]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MYC&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MYC|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/190080|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is a proto-oncogene and encodes a nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. The encoded protein forms a heterodimer with the related transcription factor MAX. This complex binds to the E box DNA consensus sequence and regulates the transcription of specific target genes. Amplification of this gene is frequently observed in numerous human cancers. Translocations involving this gene are associated with Burkitt lymphoma and multiple myeloma in human patients. There is evidence to show that translation initiates both from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site, resulting in the production of two isoforms with distinct N-termini. [provided by RefSeq, Aug 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'- CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis (PubMed:24940000). {ECO:0000269|PubMed:24940000, ECO:0000269|PubMed:25956029}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Myc-LZ|
|Myc N|
|HLH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of metanephric cap mesenchymal cell proliferation|
|regulation of metanephric cap mesenchymal cell proliferation|
|fibroblast apoptotic process|
|positive regulation of DNA methylation|
|negative regulation of monocyte differentiation|
|positive regulation of cell proliferation involved in kidney development|
|core promoter binding|
|positive regulation of metanephros development|
|oxygen transport|
|regulation of cell proliferation involved in kidney development|
|negative regulation of cell division|
|gas transport|
|regulation of monocyte differentiation|
|protein-DNA complex disassembly|
|regulation of metanephros development|
|regulation of DNA methylation|
|positive regulation of mesenchymal cell proliferation|
|ERK1 and ERK2 cascade|
|negative regulation of fibroblast proliferation|
|beta-catenin-TCF complex assembly|
|activating transcription factor binding|
|regulation of mesenchymal cell proliferation|
|positive regulation of telomerase activity|
|repressing transcription factor binding|
|positive regulation of kidney development|
|branching involved in ureteric bud morphogenesis|
|negative regulation of stress-activated protein kinase signaling cascade|
|negative regulation of stress-activated MAPK cascade|
|negative regulation of myeloid leukocyte differentiation|
|positive regulation of fibroblast proliferation|
|E-box binding|
|regulation of telomerase activity|
|ureteric bud morphogenesis|
|mesonephric tubule morphogenesis|
|regulation of kidney development|
|response to gamma radiation|
|cellular iron ion homeostasis|
|energy reserve metabolic process|
|nephron tubule morphogenesis|
|nephron epithelium morphogenesis|
|nephron morphogenesis|
|positive regulation of DNA biosynthetic process|
|renal tubule morphogenesis|
|negative regulation of myeloid cell differentiation|
|nephron tubule development|
|renal tubule development|
|iron ion homeostasis|
|regulation of fibroblast proliferation|
|positive regulation of animal organ morphogenesis|
|regulation of telomere maintenance|
|cellular response to UV|
|kidney morphogenesis|
|ureteric bud development|
|mesonephric epithelium development|
|mesonephric tubule development|
|mesonephros development|
|nephron epithelium development|
|positive regulation of response to DNA damage stimulus|
|negative regulation of leukocyte differentiation|
|cellular transition metal ion homeostasis|
|regulation of DNA biosynthetic process|
|cellular response to light stimulus|
|regulation of myeloid leukocyte differentiation|
|G1/S transition of mitotic cell cycle|
|cell cycle G1/S phase transition|
|nephron development|
|Notch signaling pathway|
|kidney epithelium development|
|transition metal ion homeostasis|
|branching morphogenesis of an epithelial tube|
|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|negative regulation of hemopoiesis|
|response to UV|
|cell cycle arrest|
|drug transport|
|response to ionizing radiation|
|positive regulation of cysteine-type endopeptidase activity|
|morphogenesis of a branching epithelium|
|protein dimerization activity|
|chromatin remodeling|
|negative regulation of MAPK cascade|
|morphogenesis of a branching structure|
|regulation of cell division|
|positive regulation of endopeptidase activity|
|cellular response to radiation|
|cellular response to hypoxia|
|positive regulation of epithelial cell proliferation|
|positive regulation of peptidase activity|
|positive regulation of DNA metabolic process|
|cellular response to decreased oxygen levels|
|cellular response to oxygen levels|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|regulation of response to DNA damage stimulus|
|regulation of myeloid cell differentiation|
|regulation of stress-activated MAPK cascade|
|energy derivation by oxidation of organic compounds|
|regulation of stress-activated protein kinase signaling cascade|
|nuclear chromatin|
|protein-containing complex disassembly|
|regulation of cysteine-type endopeptidase activity|
|protein-DNA complex subunit organization|
|DNA-binding transcription repressor activity, RNA polymerase II-specific|
|regulation of animal organ morphogenesis|
|protein-containing complex binding|
|kidney development|
|mitotic cell cycle phase transition|
|regulation of leukocyte differentiation|
|cell cycle phase transition|
|protein deubiquitination|
|renal system development|
|protein modification by small protein removal|
|epithelial tube morphogenesis|
|response to light stimulus|
|cellular response to abiotic stimulus|
|cellular response to environmental stimulus|
|urogenital system development|
|transcription factor binding|
|regulation of epithelial cell proliferation|
|response to hypoxia|
|regulation of chromosome organization|
|regulation of DNA metabolic process|
|positive regulation of proteolysis|
|response to decreased oxygen levels|
|MAPK cascade|
|response to oxygen levels|
|signal transduction by protein phosphorylation|
|cellular component disassembly|
|cellular response to drug|
|negative regulation of protein phosphorylation|
|regulation of endopeptidase activity|
|generation of precursor metabolites and energy|
|morphogenesis of an epithelium|
|response to radiation|
|negative regulation of immune system process|
|regulation of peptidase activity|
|negative regulation of phosphorylation|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|regulation of hemopoiesis|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|negative regulation of intracellular signal transduction|
|response to growth factor|
|cellular metal ion homeostasis|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|tissue morphogenesis|
|negative regulation of cell cycle|
|negative regulation of protein modification process|
|protein-containing complex|
|mitotic cell cycle process|
|metal ion homeostasis|
|cellular cation homeostasis|
|positive regulation of apoptotic process|
|cellular ion homeostasis|
|positive regulation of programmed cell death|
|tube morphogenesis|
|positive regulation of transferase activity|
|cytokine-mediated signaling pathway|
|DNA-binding transcription factor activity|
|negative regulation of cell population proliferation|
|mitotic cell cycle|
|positive regulation of cell death|
|chromatin organization|
|cation homeostasis|
|negative regulation of cell differentiation|
|inorganic ion homeostasis|
|regulation of proteolysis|
|regulation of cellular response to stress|
|cellular chemical homeostasis|
|regulation of MAPK cascade|
|positive regulation of hydrolase activity|
|cellular response to DNA damage stimulus|
|ion homeostasis|
|tube development|
|nucleolus|
|negative regulation of transcription by RNA polymerase II|
|negative regulation of apoptotic process|
|cellular homeostasis|
|negative regulation of programmed cell death|
|positive regulation of cell population proliferation|
|apoptotic process|
|negative regulation of developmental process|
|animal organ morphogenesis|
|oxidation-reduction process|
|protein phosphorylation|
|regulation of transferase activity|
|protein modification by small protein conjugation or removal|
|negative regulation of cell death|
|cell cycle process|
|cellular response to cytokine stimulus|
|response to drug|
|negative regulation of cellular protein metabolic process|
|programmed cell death|
|regulation of anatomical structure morphogenesis|
|chromosome organization|
|cell death|
|response to cytokine|
|negative regulation of protein metabolic process|
|chemical homeostasis|
|epithelium development|
|response to abiotic stimulus|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|proteolysis|
|regulation of hydrolase activity|
|phosphorylation|
|regulation of organelle organization|
|negative regulation of RNA metabolic process|
|cell cycle|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|positive regulation of catalytic activity|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|protein-containing complex assembly|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|regulation of immune system process|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|-2.2|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|-1.98|
|[[:results:exp210|LB-100 2μM R05 exp210]]|-1.87|
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|-1.78|
|[[:results:exp331|A-769662 20μM R07 exp331]]|1.7|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|1.73|
|[[:results:exp348|Cyclosporin-A 3μM R07 exp348]]|1.74|
|[[:results:exp340|BN82002 4μM R07 exp340]]|1.81|
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|1.88|
|[[:results:exp372|Ibrutinib 1μM R07 exp372]]|1.93|
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|1.97|
|[[:results:exp344|Chlorpromazine 10μM R07 exp344]]|2.05|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|2.11|
|[[:results:exp422|Wiskostatin 3μM R07 exp422]]|2.19|
|[[:results:exp358|FK-506 5μM R07 exp358]]|2.29|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:traf1|TRAF1]]|0.428|
|[[:human genes:f:fam21b|FAM21B]]|0.42|
|[[:human genes:e:eif2s1|EIF2S1]]|0.409|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 690/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|25/25|
|breast|32/33|
|central nervous system|55/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|15/15|
|kidney|21/21|
|liver|20/20|
|lung|69/75|
|lymphocyte|14/14|
|ovary|25/26|
|pancreas|24/24|
|peripheral nervous system|4/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|7/7|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|28/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 371
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.99 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MYC Expression in NALM6 Cells: 8.99'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>