======= MYCBP2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MYCBP2
  * **<color #00a2e8>Official Name</color>**: MYC binding protein 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23077|23077]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75592|O75592]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MYCBP2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MYCBP2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610392|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes an E3 ubiquitin-protein ligase and member of the PHR (Phr1/MYCBP2, highwire and RPM-1) family of proteins. The encoded protein plays a role in axon guidance and synapse formation in the developing nervous system. In mammalian cells, this protein regulates the cAMP and mTOR signaling pathways, and may additionally regulate autophagy. Reduced expression of this gene has been observed in acute lymphoblastic leukemia patients and a mutation in this gene has been identified in patients with a rare inherited vision defect. [provided by RefSeq, Mar 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**:  E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of TSC2/tuberin. Interacts with the E2 enzymes UBE2D1, UBE2D3 and UBE2L3 (in vitro). May function as a facilitator or regulator of transcriptional activation by MYC. May have a role during synaptogenesis. {ECO:0000269|PubMed:18308511}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PHR|
|RCC1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|branchiomotor neuron axon guidance|
|central nervous system projection neuron axonogenesis|
|motor neuron axon guidance|
|central nervous system neuron axonogenesis|
|Ran GTPase binding|
|regulation of axon guidance|
|circadian regulation of gene expression|
|central nervous system neuron development|
|guanyl-nucleotide exchange factor activity|
|neuromuscular process|
|positive regulation of protein ubiquitination|
|negative regulation of protein catabolic process|
|positive regulation of protein modification by small protein conjugation or removal|
|circadian rhythm|
|microtubule cytoskeleton|
|central nervous system neuron differentiation|
|regulation of axonogenesis|
|regulation of protein ubiquitination|
|regulation of chemotaxis|
|ubiquitin protein ligase activity|
|regulation of protein modification by small protein conjugation or removal|
|axon guidance|
|neuron projection guidance|
|rhythmic process|
|axon|
|regulation of cell morphogenesis involved in differentiation|
|negative regulation of catabolic process|
|axonogenesis|
|regulation of protein catabolic process|
|axon development|
|cell morphogenesis involved in neuron differentiation|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|regulation of cell morphogenesis|
|regulation of neuron projection development|
|cell part morphogenesis|
|regulation of cytoskeleton organization|
|chemotaxis|
|taxis|
|cell morphogenesis involved in differentiation|
|regulation of neuron differentiation|
|neuron projection development|
|intracellular membrane-bounded organelle|
|protein ubiquitination|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|cell morphogenesis|
|protein modification by small protein conjugation|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|zinc ion binding|
|protein homodimerization activity|
|regulation of nervous system development|
|regulation of cell development|
|central nervous system development|
|regulation of locomotion|
|protein modification by small protein conjugation or removal|
|regulation of catabolic process|
|regulation of cellular component movement|
|neuron differentiation|
|regulation of protein localization|
|regulation of anatomical structure morphogenesis|
|regulation of response to external stimulus|
|negative regulation of protein metabolic process|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|positive regulation of protein modification process|
|regulation of organelle organization|
|locomotion|
|nervous system process|
|generation of neurons|
|movement of cell or subcellular component|
|positive regulation of cellular protein metabolic process|
|neurogenesis|
|cell development|
|positive regulation of protein metabolic process|
|regulation of cell differentiation|
|regulation of protein modification process|
|system process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp67|BVD-523 15μM R02 exp67]]|-1.87|
|[[:results:exp422|Wiskostatin 3μM R07 exp422]]|-1.86|
|[[:results:exp333|All-trans-Retinoic-Acid 8μM R07 exp333]]|-1.84|
|[[:results:exp70|INK128 0.2μM R02 exp70]]|-1.83|
|[[:results:exp124|GSK343 3μM R03 exp124]]|-1.81|
|[[:results:exp295|Pyronaridine 1μM R06 exp295]]|-1.77|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|1.7|
|[[:results:exp442|Ibrutinib 10μM R08 exp442]]|1.71|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|1.8|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|1.83|
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|1.92|
|[[:results:exp481|Ethambutol 25μM R08 exp481]]|1.93|
|[[:results:exp483|FTY720 3μM R08 exp483]]|1.99|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|2.03|
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|2.2|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|2.22|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|2.28|
|[[:results:exp16|DABN 2μM R00 exp16]]|2.3|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|2.57|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|2.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13149
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.58 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MYCBP2 Expression in NALM6 Cells: 8.58'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>