======= MYH2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MYH2
  * **<color #00a2e8>Official Name</color>**: myosin heavy chain 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4620|4620]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UKX2|Q9UKX2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MYH2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MYH2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/160740|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Myosins are actin-based motor proteins that function in the generation of mechanical force in eukaryotic cells. Muscle myosins are heterohexamers composed of 2 myosin heavy chains and 2 pairs of nonidentical myosin light chains. This gene encodes a member of the class II or conventional myosin heavy chains, and functions in skeletal muscle contraction. This gene is found in a cluster of myosin heavy chain genes on chromosome 17. A mutation in this gene results in inclusion body myopathy-3. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Sep 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Muscle contraction. Required for cytoskeleton organization (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Myosin tail 1|
|Myosin head|
|Myosin N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|muscle myosin complex|
|myosin filament|
|microfilament motor activity|
|myofibril|
|muscle filament sliding|
|actin-myosin filament sliding|
|sarcomere|
|actin-mediated cell contraction|
|actin filament-based movement|
|Fc-gamma receptor signaling pathway involved in phagocytosis|
|immune response-regulating cell surface receptor signaling pathway involved in phagocytosis|
|Fc receptor mediated stimulatory signaling pathway|
|Fc-gamma receptor signaling pathway|
|calmodulin binding|
|actin filament binding|
|Fc receptor signaling pathway|
|muscle contraction|
|muscle system process|
|phagocytosis|
|immune response-activating cell surface receptor signaling pathway|
|immune response-regulating cell surface receptor signaling pathway|
|immune response-activating signal transduction|
|actin filament-based process|
|immune response-regulating signaling pathway|
|protein-containing complex|
|activation of immune response|
|positive regulation of immune response|
|immune effector process|
|regulation of immune response|
|positive regulation of immune system process|
|ATP binding|
|movement of cell or subcellular component|
|regulation of immune system process|
|vesicle-mediated transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|-2.74|
|[[:results:exp417|Tubastatin-A 2.5μM R07 exp417]]|-1.81|
|[[:results:exp115|A-366 10μM R03 exp115]]|1.7|
|[[:results:exp537|WNT3A 44ng/ml R08 exp537]]|1.7|
|[[:results:exp289|Hydroxyurea 15μM R06 exp289]]|1.72|
|[[:results:exp300|VE-822 0.04μM R06 exp300]]|1.72|
|[[:results:exp58|UM131593 0.1μM R01 exp58]]|1.82|
|[[:results:exp11|CCCP 1μM R00 exp11]]|1.87|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|1.98|
|[[:results:exp14|Cycloheximide 0.02μM R00 exp14]]|1.99|
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|2.02|
|[[:results:exp27|Pimelic-diphenylamide-106 0.5μM R00 exp27]]|2.04|
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|2.14|
|[[:results:exp287|HMS-I2 5μM R06 exp287]]|2.3|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tfip11|TFIP11]]|0.489|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.486|
|[[:human genes:c:cbwd3|CBWD3]]|0.472|
|[[:human genes:c:c14orf93|C14orf93]]|0.471|
|[[:human genes:z:znf106|ZNF106]]|0.464|
|[[:human genes:u:ubap1|UBAP1]]|0.462|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.462|
|[[:human genes:s:stil|STIL]]|0.461|
|[[:human genes:c:cbwd5|CBWD5]]|0.453|
|[[:human genes:c:cdca3|CDCA3]]|0.452|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.451|
|[[:human genes:v:vasn|VASN]]|0.448|
|[[:human genes:r:rbbp5|RBBP5]]|0.444|
|[[:human genes:r:rrp15|RRP15]]|0.44|
|[[:human genes:p:psmc1|PSMC1]]|0.439|
|[[:human genes:p:psmd3|PSMD3]]|0.434|
|[[:human genes:p:plk4|PLK4]]|0.434|
|[[:human genes:r:rad51|RAD51]]|0.433|
|[[:human genes:h:hist2h2bf|HIST2H2BF]]|0.432|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.431|
|[[:human genes:n:nol12|NOL12]]|0.429|
|[[:human genes:s:sf3a1|SF3A1]]|0.428|
|[[:human genes:t:ticrr|TICRR]]|0.428|
|[[:human genes:c:cope|COPE]]|0.427|
|[[:human genes:n:npipb5|NPIPB5]]|0.426|
|[[:human genes:c:cbwd6|CBWD6]]|0.426|
|[[:human genes:m:myo1h|MYO1H]]|0.425|
|[[:human genes:p:psmb4|PSMB4]]|0.421|
|[[:human genes:w:wdr87|WDR87]]|0.419|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.418|
|[[:human genes:m:mt1e|MT1E]]|0.417|
|[[:human genes:s:syt9|SYT9]]|0.416|
|[[:human genes:g:gosr2|GOSR2]]|0.415|
|[[:human genes:r:rfxank|RFXANK]]|0.413|
|[[:human genes:r:rps19bp1|RPS19BP1]]|0.411|
|[[:human genes:d:ddtl|DDTL]]|0.41|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.409|
|[[:human genes:r:rbm39|RBM39]]|0.407|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.405|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.404|
|[[:human genes:s:supt5h|SUPT5H]]|0.404|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.403|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.403|
|[[:human genes:c:ciapin1|CIAPIN1]]|0.402|
|[[:human genes:p:psmb3|PSMB3]]|0.402|
|[[:human genes:s:supt6h|SUPT6H]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1904
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.69 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MYH2 Expression in NALM6 Cells: -2.69'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>