======= MYL2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MYL2
  * **<color #00a2e8>Official Name</color>**: myosin light chain 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4633|4633]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P10916|P10916]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MYL2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MYL2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/160781|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Thus gene encodes the regulatory light chain associated with cardiac myosin beta (or slow) heavy chain. Ca+ triggers the phosphorylation of regulatory light chain that in turn triggers contraction. Mutations in this gene are associated with mid-left ventricular chamber type hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Contractile protein that plays a role in heart development and function (By similarity). Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin binding sites to sustain thin filament activation as a means to fine-tune myofilament calcium sensitivity to force (By similarity). During cardiogenesis plays an early role in cardiac contractility by promoting cardiac myofibril assembly (By similarity). {ECO:0000250|UniProtKB:P08733, ECO:0000250|UniProtKB:P51667}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|efhand|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|muscle cell fate specification|
|positive regulation of the force of heart contraction|
|cardiac myofibril|
|myosin heavy chain binding|
|A band|
|muscle cell fate commitment|
|cardiac myofibril assembly|
|regulation of the force of heart contraction|
|actin monomer binding|
|myofibril|
|myosin complex|
|actin-myosin filament sliding|
|muscle filament sliding|
|structural constituent of muscle|
|ventricular cardiac muscle tissue morphogenesis|
|sarcomere|
|ventricular cardiac muscle tissue development|
|muscle fiber development|
|cardiac muscle cell development|
|cardiac cell development|
|myofibril assembly|
|cardiac muscle tissue morphogenesis|
|cardiac ventricle morphogenesis|
|cardiac muscle contraction|
|muscle tissue morphogenesis|
|heart contraction|
|muscle organ morphogenesis|
|cardiac muscle cell differentiation|
|cell fate specification|
|actin-mediated cell contraction|
|post-embryonic development|
|regulation of striated muscle contraction|
|heart process|
|cellular component assembly involved in morphogenesis|
|striated muscle contraction|
|actin filament-based movement|
|actomyosin structure organization|
|cardiocyte differentiation|
|cardiac chamber morphogenesis|
|cardiac ventricle development|
|striated muscle cell development|
|muscle cell development|
|regulation of muscle contraction|
|cardiac muscle tissue development|
|cardiac chamber development|
|negative regulation of cell growth|
|striated muscle cell differentiation|
|actin cytoskeleton|
|regulation of muscle system process|
|negative regulation of growth|
|regulation of heart contraction|
|muscle cell differentiation|
|cell fate commitment|
|heart morphogenesis|
|muscle contraction|
|striated muscle tissue development|
|regulation of blood circulation|
|muscle organ development|
|muscle tissue development|
|muscle system process|
|cytoskeleton|
|blood circulation|
|circulatory system process|
|regulation of cell growth|
|supramolecular fiber organization|
|muscle structure development|
|actin cytoskeleton organization|
|heart development|
|tissue morphogenesis|
|actin filament-based process|
|regulation of system process|
|regulation of growth|
|calcium ion binding|
|organelle assembly|
|cellular component morphogenesis|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|animal organ morphogenesis|
|cytoskeleton organization|
|movement of cell or subcellular component|
|cell development|
|tissue development|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|-2.15|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|-1.96|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|-1.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16077
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MYL2 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>