======= MYLIP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MYLIP
  * **<color #00a2e8>Official Name</color>**: myosin regulatory light chain interacting protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=29116|29116]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8WY64|Q8WY64]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MYLIP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MYLIP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610082|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8. Activity depends on E2 enzymes of the UBE2D family. Proteasomal degradation of MRLC leads to inhibit neurite outgrowth in presence of NGF by counteracting the stabilization of MRLC by saposin-like protein (CNPY2/MSAP) and reducing CNPY2-stimulated neurite outgrowth. Acts as a sterol- dependent inhibitor of cellular cholesterol uptake by mediating ubiquitination and subsequent degradation of LDLR. {ECO:0000269|PubMed:10593918, ECO:0000269|PubMed:12826659, ECO:0000269|PubMed:14550572, ECO:0000269|PubMed:19520913, ECO:0000269|PubMed:20427281, ECO:0000269|PubMed:22109552}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|FERM M|
|FERM N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of low-density lipoprotein particle clearance|
|regulation of low-density lipoprotein particle receptor catabolic process|
|negative regulation of lipoprotein particle clearance|
|low-density lipoprotein particle receptor catabolic process|
|regulation of receptor catabolic process|
|low-density lipoprotein receptor particle metabolic process|
|regulation of low-density lipoprotein particle clearance|
|regulation of lipoprotein particle clearance|
|receptor catabolic process|
|protein destabilization|
|cytoskeletal protein binding|
|cholesterol homeostasis|
|sterol homeostasis|
|receptor metabolic process|
|lipid homeostasis|
|negative regulation of neuron projection development|
|negative regulation of cell projection organization|
|positive regulation of protein catabolic process|
|ubiquitin protein ligase activity|
|negative regulation of neuron differentiation|
|ubiquitin-protein transferase activity|
|regulation of cellular protein catabolic process|
|regulation of protein stability|
|negative regulation of neurogenesis|
|protein polyubiquitination|
|negative regulation of nervous system development|
|negative regulation of cell development|
|cytoskeleton|
|regulation of protein catabolic process|
|positive regulation of catabolic process|
|regulation of neuron projection development|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|regulation of neuron differentiation|
|protein catabolic process|
|protein ubiquitination|
|regulation of plasma membrane bounded cell projection organization|
|negative regulation of cellular component organization|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|protein modification by small protein conjugation|
|regulation of neurogenesis|
|regulation of cellular catabolic process|
|cellular macromolecule catabolic process|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|protein modification by small protein conjugation or removal|
|regulation of catabolic process|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|chemical homeostasis|
|negative regulation of multicellular organismal process|
|proteolysis|
|generation of neurons|
|neurogenesis|
|homeostatic process|
|positive regulation of protein metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
|regulation of cell differentiation|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|-2.44|
|[[:results:exp532|TIC10 10μM R08 exp532]]|-2.31|
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|-1.94|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|-1.83|
|[[:results:exp11|CCCP 1μM R00 exp11]]|1.93|
|[[:results:exp210|LB-100 2μM R05 exp210]]|1.96|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|1.98|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|2.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4334
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.08 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MYLIP Expression in NALM6 Cells: 4.08'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>