======= MYO16 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MYO16
  * **<color #00a2e8>Official Name</color>**: myosin XVI
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23026|23026]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y6X6|Q9Y6X6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MYO16&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MYO16|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615479|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes an unconventional myosin protein. The encoded protein has been proposed to act as a serine/threonine phosphatase-1 targeting or regulatory subunit. Studies in a rat cell line suggest that this protein may regulate cell cycle progression. A variant within this gene may be associated with susceptibility to schizophrenia and elevated expression of this gene has been observed in the frontal cortex of human schizophrenia patients. [provided by RefSeq, Mar 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. May be involved in targeting of the catalytic subunit of protein phosphatase 1 during brain development. Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ank|
|Ank 2|
|Myosin head|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|myosin complex|
|motor activity|
|cerebellum development|
|negative regulation of G1/S transition of mitotic cell cycle|
|negative regulation of cell cycle G1/S phase transition|
|metencephalon development|
|regulation of G1/S transition of mitotic cell cycle|
|hindbrain development|
|regulation of cell cycle G1/S phase transition|
|actin filament binding|
|negative regulation of mitotic cell cycle phase transition|
|negative regulation of cell cycle phase transition|
|negative regulation of mitotic cell cycle|
|negative regulation of cell cycle process|
|regulation of mitotic cell cycle phase transition|
|regulation of cell cycle phase transition|
|negative regulation of cell cycle|
|regulation of mitotic cell cycle|
|negative regulation of cell population proliferation|
|perinuclear region of cytoplasm|
|brain development|
|regulation of cell cycle process|
|head development|
|central nervous system development|
|regulation of cell cycle|
|ATP binding|
|regulation of cell population proliferation|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp264|Arsenate 40μM R06 exp264]]|-2.25|
|[[:results:exp308|Rapamycin 2μM plus FK-506 5μM R07 exp308]]|-1.96|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|-1.79|
|[[:results:exp123|GSK-LSD1 10μM R03 exp123]]|-1.71|
|[[:results:exp82|Torin1 0.08μM R02 exp82]]|1.7|
|[[:results:exp314|Dimethyloxaloylglycine 11μM R07 exp314]]|1.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12723
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.78 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MYO16 Expression in NALM6 Cells: 0.78'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>