======= MYO1C =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MYO1C
  * **<color #00a2e8>Official Name</color>**: myosin IC
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4641|4641]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O00159|O00159]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MYO1C&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MYO1C|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606538|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the unconventional myosin protein family, which are actin-based molecular motors. The protein is found in the cytoplasm, and one isoform with a unique N-terminus is also found in the nucleus. The nuclear isoform associates with RNA polymerase I and II and functions in transcription initiation. The mouse ortholog of this protein also functions in intracellular vesicle transport to the plasma membrane. Multiple transcript variants encoding different isoforms have been found for this gene. The related gene myosin IE has been referred to as myosin IC in the literature, but it is a distinct locus on chromosome 19. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Involved in glucose transporter recycling in response to insulin by regulating movement of intracellular GLUT4-containing vesicles to the plasma membrane. Component of the hair cell's (the sensory cells of the inner ear) adaptation-motor complex. Acts as a mediator of adaptation of mechanoelectrical transduction in stereocilia of vestibular hair cells. Binds phosphoinositides and links the actin cytoskeleton to cellular membranes. {ECO:0000269|PubMed:24636949}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Myosin TH1|
|Myosin head|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|vesicle transport along actin filament|
|stereocilium membrane|
|positive regulation of vascular endothelial growth factor signaling pathway|
|positive regulation of cell migration by vascular endothelial growth factor signaling pathway|
|unconventional myosin complex|
|actin filament-based transport|
|Ral GTPase binding|
|actin-dependent ATPase activity|
|regulation of vascular endothelial growth factor signaling pathway|
|regulation of cellular response to vascular endothelial growth factor stimulus|
|microfilament motor activity|
|vascular endothelial growth factor signaling pathway|
|regulation of bicellular tight junction assembly|
|positive regulation of cellular response to insulin stimulus|
|positive regulation of protein targeting to membrane|
|filamentous actin|
|basal plasma membrane|
|regulation of protein targeting to membrane|
|cellular response to vascular endothelial growth factor stimulus|
|vesicle cytoskeletal trafficking|
|brush border|
|lateral plasma membrane|
|phagocytic vesicle|
|microvillus|
|positive regulation of gene expression, epigenetic|
|stress fiber|
|nuclear pore|
|regulation of cellular response to insulin stimulus|
|regulation of protein targeting|
|regulation of cell junction assembly|
|positive regulation of actin filament polymerization|
|ruffle membrane|
|actin filament-based movement|
|positive regulation of protein localization to membrane|
|positive regulation of protein polymerization|
|immune response-regulating cell surface receptor signaling pathway involved in phagocytosis|
|Fc-gamma receptor signaling pathway involved in phagocytosis|
|Fc receptor mediated stimulatory signaling pathway|
|Fc-gamma receptor signaling pathway|
|cytoplasmic vesicle membrane|
|positive regulation of intracellular protein transport|
|mRNA transport|
|protein targeting to membrane|
|cellular response to interferon-gamma|
|regulation of actin filament polymerization|
|establishment of vesicle localization|
|cytoskeleton-dependent intracellular transport|
|response to interferon-gamma|
|regulation of actin polymerization or depolymerization|
|regulation of actin filament length|
|vesicle localization|
|regulation of protein localization to membrane|
|protein C-terminus binding|
|nucleic acid transport|
|RNA transport|
|establishment of RNA localization|
|positive regulation of supramolecular fiber organization|
|calmodulin binding|
|actin filament binding|
|positive regulation of intracellular transport|
|RNA localization|
|positive regulation of cytoskeleton organization|
|regulation of protein polymerization|
|membrane raft|
|regulation of intracellular protein transport|
|regulation of gene expression, epigenetic|
|nucleobase-containing compound transport|
|Fc receptor signaling pathway|
|positive regulation of protein complex assembly|
|regulation of actin filament organization|
|establishment of protein localization to membrane|
|regulation of cellular response to growth factor stimulus|
|nuclear body|
|positive regulation of cellular protein localization|
|phagocytosis|
|signaling receptor binding|
|regulation of actin cytoskeleton organization|
|regulation of supramolecular fiber organization|
|regulation of intracellular transport|
|protein targeting|
|establishment of organelle localization|
|regulation of cellular component size|
|regulation of actin filament-based process|
|positive regulation of protein transport|
|immune response-activating cell surface receptor signaling pathway|
|regulation of protein complex assembly|
|positive regulation of establishment of protein localization|
|protein localization to membrane|
|immune response-regulating cell surface receptor signaling pathway|
|cellular response to growth factor stimulus|
|positive regulation of cell migration|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|regulation of anatomical structure size|
|positive regulation of cellular component biogenesis|
|positive regulation of cell motility|
|response to growth factor|
|positive regulation of cellular component movement|
|regulation of cellular protein localization|
|regulation of cytoskeleton organization|
|positive regulation of locomotion|
|immune response-activating signal transduction|
|actin filament-based process|
|organelle localization|
|immune response-regulating signaling pathway|
|positive regulation of organelle organization|
|activation of immune response|
|regulation of protein transport|
|enzyme linked receptor protein signaling pathway|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|innate immune response|
|regulation of cell migration|
|nucleolus|
|positive regulation of immune response|
|regulation of cell motility|
|regulation of cellular localization|
|defense response to other organism|
|regulation of cellular component biogenesis|
|regulation of locomotion|
|positive regulation of transport|
|intracellular protein transport|
|regulation of cellular component movement|
|cellular response to cytokine stimulus|
|regulation of protein localization|
|immune effector process|
|response to cytokine|
|positive regulation of immune system process|
|regulation of immune response|
|positive regulation of cellular component organization|
|regulation of organelle organization|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|ATP binding|
|protein transport|
|intracellular transport|
|peptide transport|
|movement of cell or subcellular component|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|regulation of immune system process|
|positive regulation of signal transduction|
|positive regulation of cell communication|
|positive regulation of signaling|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of transport|
|immune response|
|vesicle-mediated transport|
|positive regulation of gene expression|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|-2.07|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|-1.81|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|-1.78|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|1.89|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7631
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.27 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MYO1C Expression in NALM6 Cells: 3.27'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>