======= MYO1E =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MYO1E
  * **<color #00a2e8>Official Name</color>**: myosin IE
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4643|4643]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q12965|Q12965]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MYO1E&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MYO1E|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601479|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the nonmuscle class I myosins which are a subgroup of the unconventional myosin protein family. The unconventional myosin proteins function as actin-based molecular motors. Class I myosins are characterized by a head (motor) domain, a regulatory domain and a either a short or long tail domain. Among the class I myosins, this protein is distinguished by a long tail domain that is involved in crosslinking actin filaments. This protein localizes to the cytoplasm and may be involved in intracellular movement and membrane trafficking. Mutations in this gene are the cause of focal segmental glomerulosclerosis-6. This gene has been referred to as myosin IC in the literature but is distinct from the myosin IC gene located on chromosome 17. [provided by RefSeq, Jan 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. Binds to membranes containing anionic phospholipids via its tail domain. Required for normal morphology of the glomerular basement membrane, normal development of foot processes by kidney podocytes and normal kidney function. In dendritic cells, may control the movement of class II-containing cytoplasmic vesicles along the actin cytoskeleton by connecting them with the actin network via ARL14EP and ARL14. {ECO:0000269|PubMed:11940582, ECO:0000269|PubMed:17257598, ECO:0000269|PubMed:20860408}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Myosin TH1|
|SH3 1|
|SH3 2|
|Myosin head|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|post-embryonic hemopoiesis|
|glomerular visceral epithelial cell development|
|glomerular basement membrane development|
|glomerular epithelial cell development|
|glomerular filtration|
|renal filtration|
|post-embryonic animal organ development|
|renal filtration cell differentiation|
|glomerular visceral epithelial cell differentiation|
|glomerular epithelial cell differentiation|
|microfilament motor activity|
|glomerular epithelium development|
|ATPase activity, coupled|
|clathrin-coated endocytic vesicle|
|epithelial cell differentiation involved in kidney development|
|platelet-derived growth factor receptor signaling pathway|
|myosin complex|
|cell differentiation involved in kidney development|
|motor activity|
|brush border|
|glomerulus development|
|adherens junction|
|vasculogenesis|
|phosphatidylinositol binding|
|post-embryonic development|
|nephron epithelium development|
|renal system process|
|actin filament-based movement|
|nephron development|
|kidney epithelium development|
|cell-cell junction|
|epithelial cell development|
|calmodulin binding|
|actin filament binding|
|actin cytoskeleton|
|kidney development|
|renal system development|
|urogenital system development|
|extracellular matrix organization|
|cytoskeleton|
|in utero embryonic development|
|extracellular structure organization|
|blood vessel morphogenesis|
|blood vessel development|
|vasculature development|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|cardiovascular system development|
|endocytosis|
|hemopoiesis|
|actin filament-based process|
|hematopoietic or lymphoid organ development|
|chordate embryonic development|
|immune system development|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|import into cell|
|epithelial cell differentiation|
|enzyme linked receptor protein signaling pathway|
|tube development|
|circulatory system development|
|embryo development|
|epithelium development|
|ATP binding|
|movement of cell or subcellular component|
|cell development|
|tissue development|
|vesicle-mediated transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp70|INK128 0.2μM R02 exp70]]|-1.77|
|[[:results:exp125|GSK461364A 0.005μM R03 exp125]]|1.87|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5060
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.42 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MYO1E Expression in NALM6 Cells: 2.42'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>