======= MYOG =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MYOG
  * **<color #00a2e8>Official Name</color>**: myogenin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4656|4656]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P15173|P15173]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MYOG&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MYOG|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/159980|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation, cell cycle exit and muscle atrophy. Essential for the development of functional embryonic skeletal fiber muscle differentiation. However is dispensable for postnatal skeletal muscle growth; phosphorylation by CAMK2G inhibits its transcriptional activity in respons to muscle activity. Required for the recruitment of the FACT complex to muscle-specific promoter regions, thus promoting gene expression initiation. During terminal myoblast differentiation, plays a role as a strong activator of transcription at loci with an open chromatin structure previously initiated by MYOD1. Together with MYF5 and MYOD1, co-occupies muscle-specific gene promoter core regions during myogenesis. Cooperates also with myocyte-specific enhancer factor MEF2D and BRG1-dependent recruitment of SWI/SNF chromatin- remodeling enzymes to alter chromatin structure at myogenic late gene promoters. Facilitates cell cycle exit during terminal muscle differentiation through the up-regulation of miR-20a expression, which in turn represses genes involved in cell cycle progression. Binds to the E-box containing (E1) promoter region of the miR-20a gene. Plays also a role in preventing reversal of muscle cell differentiation. Contributes to the atrophy-related gene expression in adult denervated muscles. Induces fibroblasts to differentiate into myoblasts (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|HLH|
|Basic|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|response to magnetism|
|cellular response to magnetism|
|positive regulation of muscle atrophy|
|response to electrical stimulus involved in regulation of muscle adaptation|
|response to muscle activity involved in regulation of muscle adaptation|
|regulation of muscle atrophy|
|skeletal muscle atrophy|
|positive regulation of muscle adaptation|
|positive regulation of skeletal muscle fiber development|
|striated muscle atrophy|
|muscle atrophy|
|response to denervation involved in regulation of muscle adaptation|
|response to muscle inactivity involved in regulation of muscle adaptation|
|positive regulation of oxidative phosphorylation|
|regulation of skeletal muscle fiber development|
|response to gravity|
|response to muscle inactivity|
|skeletal muscle adaptation|
|cellular response to lithium ion|
|regulation of skeletal muscle satellite cell proliferation|
|negative regulation of glycolytic process|
|response to inactivity|
|regulation of skeletal muscle cell proliferation|
|response to stimulus involved in regulation of muscle adaptation|
|muscle cell fate commitment|
|negative regulation of purine nucleotide metabolic process|
|positive regulation of myoblast fusion|
|negative regulation of nucleotide metabolic process|
|mRNA transcription by RNA polymerase II|
|regulation of myoblast fusion|
|response to lithium ion|
|positive regulation of myoblast differentiation|
|skeletal muscle fiber development|
|response to muscle activity|
|negative regulation of ATP metabolic process|
|mRNA transcription|
|positive regulation of skeletal muscle tissue development|
|myotube cell development|
|positive regulation of syncytium formation by plasma membrane fusion|
|striated muscle adaptation|
|regulation of syncytium formation by plasma membrane fusion|
|regulation of oxidative phosphorylation|
|positive regulation of myotube differentiation|
|muscle adaptation|
|skeletal muscle tissue regeneration|
|myoblast differentiation|
|cellular response to estradiol stimulus|
|negative regulation of cellular carbohydrate metabolic process|
|response to electrical stimulus|
|protein-DNA complex|
|positive regulation of ATP metabolic process|
|negative regulation of carbohydrate metabolic process|
|regulation of skeletal muscle tissue development|
|skeletal muscle cell differentiation|
|E-box binding|
|regulation of myoblast differentiation|
|myotube differentiation|
|regulation of myotube differentiation|
|muscle fiber development|
|positive regulation of striated muscle cell differentiation|
|tissue regeneration|
|response to activity|
|positive regulation of striated muscle tissue development|
|positive regulation of muscle organ development|
|cellular response to retinoic acid|
|positive regulation of muscle tissue development|
|chromatin DNA binding|
|regulation of glycolytic process|
|positive regulation of cell cycle arrest|
|regulation of muscle adaptation|
|positive regulation of muscle cell differentiation|
|regulation of carbohydrate catabolic process|
|negative regulation of small molecule metabolic process|
|regulation of striated muscle cell differentiation|
|regulation of cell cycle arrest|
|response to retinoic acid|
|regulation of purine nucleotide metabolic process|
|regulation of nucleotide metabolic process|
|regulation of ATP metabolic process|
|skeletal muscle tissue development|
|regulation of striated muscle tissue development|
|skeletal muscle organ development|
|striated muscle cell development|
|regulation of muscle tissue development|
|regulation of muscle organ development|
|response to estradiol|
|regulation of cellular carbohydrate metabolic process|
|muscle cell development|
|regulation of muscle cell differentiation|
|regeneration|
|regulation of generation of precursor metabolites and energy|
|cellular response to metal ion|
|striated muscle cell differentiation|
|regulation of carbohydrate metabolic process|
|transcription factor complex|
|cellular response to acid chemical|
|cellular response to inorganic substance|
|regulation of muscle system process|
|cellular response to tumor necrosis factor|
|muscle cell differentiation|
|cell fate commitment|
|ossification|
|response to tumor necrosis factor|
|striated muscle tissue development|
|positive regulation of cell cycle process|
|muscle organ development|
|muscle tissue development|
|muscle system process|
|negative regulation of catabolic process|
|RNA polymerase II regulatory region sequence-specific DNA binding|
|cellular response to abiotic stimulus|
|cellular response to environmental stimulus|
|response to acid chemical|
|response to metal ion|
|positive regulation of cell cycle|
|developmental growth|
|growth|
|sequence-specific DNA binding|
|regulation of small molecule metabolic process|
|negative regulation of phosphorylation|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|muscle structure development|
|wound healing|
|transcription by RNA polymerase II|
|protein heterodimerization activity|
|cellular response to growth factor stimulus|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|cellular response to lipid|
|response to growth factor|
|response to inorganic substance|
|positive regulation of cell development|
|cellular response to organic cyclic compound|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|response to wounding|
|regulation of system process|
|cellular response to hormone stimulus|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|DNA-binding transcription factor activity|
|negative regulation of cell population proliferation|
|mRNA metabolic process|
|regulation of cell cycle process|
|response to lipid|
|response to hormone|
|response to organic cyclic compound|
|regulation of cell development|
|positive regulation of cell differentiation|
|regulation of catabolic process|
|cellular response to cytokine stimulus|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|nucleobase-containing compound biosynthetic process|
|response to cytokine|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|response to abiotic stimulus|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|regulation of cell cycle|
|positive regulation of cellular component organization|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|organic cyclic compound biosynthetic process|
|cell cycle|
|positive regulation of developmental process|
|negative regulation of nucleobase-containing compound metabolic process|
|response to endogenous stimulus|
|positive regulation of transcription, DNA-templated|
|response to oxygen-containing compound|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of phosphorylation|
|regulation of cell population proliferation|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|macromolecule biosynthetic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 4/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9307
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.24 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MYOG Expression in NALM6 Cells: -2.24'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>