======= N6AMT1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: N6AMT1
  * **<color #00a2e8>Official Name</color>**: N-6 adenine-specific DNA methyltransferase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=29104|29104]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y5N5|Q9Y5N5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=N6AMT1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20N6AMT1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Heterodimeric methyltransferase that catalyzes N5- methylation of ETF1 on 'Gln-185', using S-adenosyl L-methionine as methyl donor. ETF1 needs to be complexed to ERF3 in its GTP-bound form to be efficiently methylated. May play a role in the modulation of arsenic-induced toxicity. May be involved in the conversion of monomethylarsonous acid (3+) into the less toxic dimethylarsonic acid. {ECO:0000269|PubMed:18539146, ECO:0000269|PubMed:21193388}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|MTS|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|eRF1 methyltransferase complex|
|protein-glutamine N-methyltransferase activity|
|arsonoacetate metabolic process|
|DNA methylation on adenine|
|site-specific DNA-methyltransferase (adenine-specific) activity|
|methylarsonite methyltransferase activity|
|peptidyl-glutamine methylation|
|protein methyltransferase activity|
|S-adenosylmethionine-dependent methyltransferase activity|
|toxin metabolic process|
|DNA alkylation|
|DNA methylation|
|secondary metabolic process|
|DNA methylation or demethylation|
|DNA modification|
|translational termination|
|xenobiotic metabolic process|
|protein alkylation|
|protein methylation|
|cellular protein complex disassembly|
|positive regulation of cell growth|
|cellular response to xenobiotic stimulus|
|nucleic acid binding|
|protein-containing complex disassembly|
|macromolecule methylation|
|positive regulation of growth|
|response to xenobiotic stimulus|
|methylation|
|translation|
|cellular component disassembly|
|peptide biosynthetic process|
|regulation of cell growth|
|amide biosynthetic process|
|peptide metabolic process|
|monocarboxylic acid metabolic process|
|protein-containing complex|
|regulation of growth|
|DNA metabolic process|
|cellular amide metabolic process|
|carboxylic acid metabolic process|
|oxoacid metabolic process|
|organic acid metabolic process|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|small molecule metabolic process|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|-2.74|
|[[:results:exp125|GSK461364A 0.005μM R03 exp125]]|-2.52|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|-2.48|
|[[:results:exp278|CVT-10216 0.1μM R06 exp278]]|-2.41|
|[[:results:exp486|Heregulin-B 44ng/ml R08 exp486]]|-2.12|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-2.06|
|[[:results:exp298|Sucrose 20000μM R06 exp298]]|-1.87|
|[[:results:exp58|UM131593 0.1μM R01 exp58]]|-1.81|
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|-1.73|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|1.71|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|1.77|
|[[:results:exp534|Trientine 500μM R08 exp534]]|1.83|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|1.85|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|1.88|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|1.89|
|[[:results:exp108|Vinblastine 0.2μM R03 exp108]]|1.89|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|1.92|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|1.94|
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|1.95|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|1.98|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|2.05|
|[[:results:exp360|Genistein 15μM R07 exp360]]|2.09|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|2.18|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|2.22|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|2.22|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|2.26|
|[[:results:exp532|TIC10 10μM R08 exp532]]|2.27|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|2.28|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|2.32|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|2.35|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|2.36|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|2.45|
|[[:results:exp539|42°C R08 exp539]]|2.52|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|2.59|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|2.6|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|2.92|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|3.2|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|3.3|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|3.44|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|3.62|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:g:gemin8|GEMIN8]]|0.534|
|[[:human genes:t:thg1l|THG1L]]|0.528|
|[[:human genes:d:dohh|DOHH]]|0.502|
|[[:human genes:u:urm1|URM1]]|0.488|
|[[:human genes:a:atxn10|ATXN10]]|0.483|
|[[:human genes:c:c14orf80|C14orf80]]|0.474|
|[[:human genes:z:znhit1|ZNHIT1]]|0.472|
|[[:human genes:s:srp14|SRP14]]|0.472|
|[[:human genes:g:gemin6|GEMIN6]]|0.467|
|[[:human genes:e:elp3|ELP3]]|0.467|
|[[:human genes:t:tmem242|TMEM242]]|0.464|
|[[:human genes:p:ppcdc|PPCDC]]|0.461|
|[[:human genes:s:snapc5|SNAPC5]]|0.46|
|[[:human genes:e:eif3f|EIF3F]]|0.457|
|[[:human genes:h:hccs|HCCS]]|0.457|
|[[:human genes:r:rpia|RPIA]]|0.456|
|[[:human genes:m:mocs3|MOCS3]]|0.455|
|[[:human genes:t:tube1|TUBE1]]|0.454|
|[[:human genes:g:gemin7|GEMIN7]]|0.453|
|[[:human genes:t:tpi1|TPI1]]|0.451|
|[[:human genes:t:tubd1|TUBD1]]|0.45|
|[[:human genes:e:elp2|ELP2]]|0.448|
|[[:human genes:k:kdsr|KDSR]]|0.447|
|[[:human genes:c:cd2bp2|CD2BP2]]|0.441|
|[[:human genes:v:vezt|VEZT]]|0.44|
|[[:human genes:d:dnlz|DNLZ]]|0.44|
|[[:human genes:t:tut1|TUT1]]|0.439|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.437|
|[[:human genes:d:dr1|DR1]]|0.436|
|[[:human genes:g:g6pd|G6PD]]|0.433|
|[[:human genes:a:aar2|AAR2]]|0.432|
|[[:human genes:m:mlst8|MLST8]]|0.428|
|[[:human genes:c:c15orf41|C15orf41]]|0.428|
|[[:human genes:d:dhrsx|DHRSX]]|0.427|
|[[:human genes:l:lsm11|LSM11]]|0.426|
|[[:human genes:s:slc25a26|SLC25A26]]|0.425|
|[[:human genes:p:pgm3|PGM3]]|0.425|
|[[:human genes:r:rptor|RPTOR]]|0.424|
|[[:human genes:d:ddx39a|DDX39A]]|0.424|
|[[:human genes:a:atic|ATIC]]|0.422|
|[[:human genes:p:pmm2|PMM2]]|0.421|
|[[:human genes:u:uap1|UAP1]]|0.421|
|[[:human genes:s:slc25a19|SLC25A19]]|0.421|
|[[:human genes:b:bak1|BAK1]]|0.42|
|[[:human genes:p:ppp6c|PPP6C]]|0.418|
|[[:human genes:r:rabggtb|RABGGTB]]|0.415|
|[[:human genes:p:ppcs|PPCS]]|0.413|
|[[:human genes:g:gmppb|GMPPB]]|0.413|
|[[:human genes:l:lsm10|LSM10]]|0.412|
|[[:human genes:p:pmvk|PMVK]]|0.41|
|[[:human genes:t:trmt61a|TRMT61A]]|0.41|
|[[:human genes:f:fh|FH]]|0.407|
|[[:human genes:e:eno1|ENO1]]|0.407|
|[[:human genes:m:mapkap1|MAPKAP1]]|0.406|
|[[:human genes:m:mtor|MTOR]]|0.405|
|[[:human genes:b:bcs1l|BCS1L]]|0.405|
|[[:human genes:s:smek1|SMEK1]]|0.405|
|[[:human genes:p:ptar1|PTAR1]]|0.405|
|[[:human genes:u:uqcr10|UQCR10]]|0.404|
|[[:human genes:p:pdpk1|PDPK1]]|0.403|
|[[:human genes:s:scap|SCAP]]|0.402|
|[[:human genes:a:atp2b1|ATP2B1]]|0.402|
|[[:human genes:t:tsen54|TSEN54]]|0.4|
|[[:human genes:w:wdr92|WDR92]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 81/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|2/28|
|bone|3/26|
|breast|1/33|
|central nervous system|4/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|3/21|
|liver|4/20|
|lung|10/75|
|lymphocyte|3/16|
|ovary|2/26|
|pancreas|4/24|
|peripheral nervous system|1/16|
|plasma cell|3/15|
|prostate|0/1|
|skin|5/24|
|soft tissue|0/9|
|thyroid|1/2|
|upper aerodigestive|5/22|
|urinary tract|6/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1367
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.55 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='N6AMT1 Expression in NALM6 Cells: 3.55'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>