======= NAGA =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: N/AGA
  * **<color #00a2e8>Official Name</color>**: alpha-N-acetylgalactosaminidase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4668|4668]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P17050|P17050]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NAGA&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NAGA|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/104170|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  NAGA encodes the lysosomal enzyme alpha-N-acetylgalactosaminidase, which cleaves alpha-N-acetylgalactosaminyl moieties from glycoconjugates. Mutations in NAGA have been identified as the cause of  Schindler disease types I and II (type II also known as Kanzaki disease). [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Removes terminal alpha-N-acetylgalactosamine residues from glycolipids and glycopeptides. Required for the breakdown of glycolipids. {ECO:0000269|PubMed:9741689}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Melibiase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|alpha-N-acetylgalactosaminidase activity|
|alpha-galactosidase activity|
|glycosylceramide catabolic process|
|glycoside catabolic process|
|glycosphingolipid catabolic process|
|glycolipid catabolic process|
|glycosylceramide metabolic process|
|ceramide catabolic process|
|glycoside metabolic process|
|sphingolipid catabolic process|
|membrane lipid catabolic process|
|glycosyl compound catabolic process|
|oligosaccharide metabolic process|
|glycosphingolipid metabolic process|
|ceramide metabolic process|
|glycolipid metabolic process|
|liposaccharide metabolic process|
|carbohydrate catabolic process|
|glycosyl compound metabolic process|
|sphingolipid metabolic process|
|carbohydrate derivative catabolic process|
|cellular lipid catabolic process|
|membrane lipid metabolic process|
|lysosome|
|lipid catabolic process|
|carbohydrate metabolic process|
|cellular amide metabolic process|
|protein homodimerization activity|
|cellular lipid metabolic process|
|carbohydrate derivative metabolic process|
|organonitrogen compound catabolic process|
|lipid metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp330|5-Azacytidine 2μM R07 exp330]]|1.81|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|1.89|
|[[:results:exp532|TIC10 10μM R08 exp532]]|1.94|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10017
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.12 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NAGA Expression in NALM6 Cells: 5.12'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>