======= NANOS2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: N/ANOS2
  * **<color #00a2e8>Official Name</color>**: nanos C2HC-type zinc finger 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=339345|339345]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P60321|P60321]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NANOS2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NANOS2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608228|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a key role in the sexual differentiation of germ cells by promoting the male fate but suppressing the female fate. Represses the female fate pathways by suppressing meiosis, which in turn results in the promotion of the male fate. Maintains the suppression of meiosis by preventing STRA8 expression, which is required for premeiotic DNA replication, after CYP26B1 is decreased. Regulates the localization of the CCR4-NOT deadenylation complex to P-bodies and plays a role in recruiting the complex to trigger the degradation of mRNAs involved in meiosis. Required for the maintenance of the spermatogonial stem cell population. Not essential for the assembly of P-bodies but is required for the maintenance of their normal state (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-nanos|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|germ-line stem cell population maintenance|
|negative regulation of meiotic nuclear division|
|negative regulation of meiotic cell cycle|
|positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|
|regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|
|regulation of meiotic nuclear division|
|negative regulation of nuclear division|
|positive regulation of mRNA catabolic process|
|regulation of meiotic cell cycle|
|negative regulation of reproductive process|
|positive regulation of mRNA metabolic process|
|P-body|
|negative regulation of translation|
|stem cell population maintenance|
|maintenance of cell number|
|negative regulation of cellular amide metabolic process|
|regulation of reproductive process|
|mRNA binding|
|regulation of nuclear division|
|regulation of mRNA catabolic process|
|mRNA catabolic process|
|RNA catabolic process|
|negative regulation of cell cycle process|
|regulation of mRNA metabolic process|
|regulation of translation|
|positive regulation of cellular catabolic process|
|negative regulation of organelle organization|
|nucleobase-containing compound catabolic process|
|regulation of cellular amide metabolic process|
|positive regulation of catabolic process|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|organic cyclic compound catabolic process|
|posttranscriptional regulation of gene expression|
|spermatogenesis|
|male gamete generation|
|negative regulation of cell cycle|
|gamete generation|
|mRNA metabolic process|
|perinuclear region of cytoplasm|
|negative regulation of cellular component organization|
|regulation of cell cycle process|
|multicellular organismal reproductive process|
|sexual reproduction|
|regulation of cellular catabolic process|
|zinc ion binding|
|multicellular organism reproduction|
|cellular macromolecule catabolic process|
|regulation of catabolic process|
|multi-organism reproductive process|
|negative regulation of cellular protein metabolic process|
|macromolecule catabolic process|
|negative regulation of protein metabolic process|
|regulation of cell cycle|
|regulation of organelle organization|
|negative regulation of cellular macromolecule biosynthetic process|
|reproductive process|
|reproduction|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|RNA metabolic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
|positive regulation of nucleobase-containing compound metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|-1.89|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:prim1|PRIM1]]|0.403|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11772
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -6.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NANOS2 Expression in NALM6 Cells: -6.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>