======= NANOS3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: N/ANOS3
  * **<color #00a2e8>Official Name</color>**: nanos C2HC-type zinc finger 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=342977|342977]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P60323|P60323]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NANOS3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NANOS3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608229|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role in the maintenance of the undifferentiated state of germ cells regulating the spermatogonia cell cycle and inducing a prolonged transit in G1 phase. Affects cell proliferation probably by repressing translation of specific mRNAs. Maintains the germ cell lineage by suppressing both Bax- dependent and -independent apoptotic pathways. Essential in the early stage embryo to protect the migrating primordial germ cells (PGCs) from apoptosis. {ECO:0000269|PubMed:21421998}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-nanos|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|
|regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|
|positive regulation of mRNA catabolic process|
|cytoplasmic stress granule|
|oogenesis|
|positive regulation of mRNA metabolic process|
|P-body|
|female gamete generation|
|negative regulation of translation|
|negative regulation of cellular amide metabolic process|
|regulation of mRNA catabolic process|
|negative regulation of apoptotic signaling pathway|
|germ cell development|
|regulation of mRNA metabolic process|
|regulation of translation|
|cellular process involved in reproduction in multicellular organism|
|positive regulation of cellular catabolic process|
|regulation of apoptotic signaling pathway|
|regulation of cellular amide metabolic process|
|positive regulation of catabolic process|
|posttranscriptional regulation of gene expression|
|spermatogenesis|
|male gamete generation|
|developmental process involved in reproduction|
|gamete generation|
|perinuclear region of cytoplasm|
|multicellular organismal reproductive process|
|sexual reproduction|
|regulation of cellular catabolic process|
|zinc ion binding|
|multicellular organism reproduction|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|regulation of catabolic process|
|negative regulation of cell death|
|multi-organism reproductive process|
|negative regulation of cellular protein metabolic process|
|negative regulation of protein metabolic process|
|regulation of cell cycle|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|negative regulation of cellular macromolecule biosynthetic process|
|RNA binding|
|reproductive process|
|reproduction|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|regulation of programmed cell death|
|negative regulation of response to stimulus|
|cell development|
|regulation of cell death|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of nucleobase-containing compound metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.627|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5554
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -3.59 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NANOS3 Expression in NALM6 Cells: -3.59'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>