======= NARFL =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CIAO3
  * **<color #00a2e8>Official Name</color>**: cytosolic iron-sulfur assembly component 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=64428|64428]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H6Q4|Q9H6Q4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NARFL&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NARFL|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611118|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to negatively regulate the level of HIF1A expression, although this effect could be indirect. {ECO:0000269|PubMed:16956324, ECO:0000269|PubMed:18270200}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Fe hyd SSU|
|Fe hyd lg C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|CIA complex|
|oxygen homeostasis|
|gas homeostasis|
|metallo-sulfur cluster assembly|
|iron-sulfur cluster assembly|
|4 iron, 4 sulfur cluster binding|
|hematopoietic progenitor cell differentiation|
|cofactor biosynthetic process|
|response to hypoxia|
|response to decreased oxygen levels|
|sulfur compound metabolic process|
|response to oxygen levels|
|cofactor metabolic process|
|hemopoiesis|
|hematopoietic or lymphoid organ development|
|immune system development|
|chemical homeostasis|
|response to abiotic stimulus|
|homeostatic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|-1.94|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|-1.74|
|[[:results:exp530|Thioridazine 5μM R08 exp530]]|1.71|
|[[:results:exp187|proTAME 5μM R04 exp187]]|1.76|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|1.78|
|[[:results:exp425|Beta-Estradiol 0.55μM R07 exp425]]|1.83|
|[[:results:exp107|UMK57 0.6μM R03 exp107]]|1.84|
|[[:results:exp389|PF-06409577 20μM R07 exp389]]|1.86|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|1.88|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|1.9|
|[[:results:exp442|Ibrutinib 10μM R08 exp442]]|1.94|
|[[:results:exp462|Cadmium 60μM R08 exp462]]|1.95|
|[[:results:exp438|NN-Diethyl-meta-toluamide 500μM R08 exp438]]|1.96|
|[[:results:exp11|CCCP 1μM R00 exp11]]|1.99|
|[[:results:exp506|Momordin-Ic 10μM R08 exp506]]|2.04|
|[[:results:exp177|Apcin 25μM plus proTAME 2μM R04 exp177]]|2.09|
|[[:results:exp391|Pomalidomide 20μM R07 exp391]]|2.29|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:polr2j3|POLR2J3]]|0.579|
|[[:human genes:r:rbm39|RBM39]]|0.562|
|[[:human genes:p:psmb4|PSMB4]]|0.556|
|[[:human genes:c:cactin|CACTIN]]|0.543|
|[[:human genes:v:vasn|VASN]]|0.534|
|[[:human genes:c:chd4|CHD4]]|0.528|
|[[:human genes:p:pan3|PAN3]]|0.528|
|[[:human genes:t:tceb3c|TCEB3C]]|0.524|
|[[:human genes:r:rpl35|RPL35]]|0.523|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.519|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.515|
|[[:human genes:s:smtn|SMTN]]|0.514|
|[[:human genes:m:mt1e|MT1E]]|0.508|
|[[:human genes:t:tfip11|TFIP11]]|0.507|
|[[:human genes:r:rad51|RAD51]]|0.507|
|[[:human genes:i:igfn1|IGFN1]]|0.503|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.502|
|[[:human genes:c:ctr9|CTR9]]|0.502|
|[[:human genes:d:dtl|DTL]]|0.5|
|[[:human genes:i:ik|IK]]|0.499|
|[[:human genes:p:prpf19|PRPF19]]|0.499|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.498|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.498|
|[[:human genes:c:cdc73|CDC73]]|0.498|
|[[:human genes:p:paf1|PAF1]]|0.497|
|[[:human genes:r:rps12|RPS12]]|0.496|
|[[:human genes:s:sf3a3|SF3A3]]|0.495|
|[[:human genes:e:exosc9|EXOSC9]]|0.491|
|[[:human genes:r:rpl6|RPL6]]|0.486|
|[[:human genes:r:rps2|RPS2]]|0.484|
|[[:human genes:d:dnm2|DNM2]]|0.483|
|[[:human genes:o:orc6|ORC6]]|0.483|
|[[:human genes:d:ddtl|DDTL]]|0.477|
|[[:human genes:p:psmd1|PSMD1]]|0.477|
|[[:human genes:s:snrpa1|SNRPA1]]|0.476|
|[[:human genes:p:ppm1d|PPM1D]]|0.475|
|[[:human genes:c:copg1|COPG1]]|0.475|
|[[:human genes:p:psma7|PSMA7]]|0.474|
|[[:human genes:o:orc1|ORC1]]|0.473|
|[[:human genes:r:rpl30|RPL30]]|0.472|
|[[:human genes:s:snip1|SNIP1]]|0.471|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.471|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.47|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.47|
|[[:human genes:k:kctd17|KCTD17]]|0.47|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.469|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.469|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.466|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.466|
|[[:human genes:s:sh3bp1|SH3BP1]]|0.463|
|[[:human genes:c:cdca3|CDCA3]]|0.463|
|[[:human genes:n:nup160|NUP160]]|0.463|
|[[:human genes:r:ranbp2|RANBP2]]|0.462|
|[[:human genes:t:tspy2|TSPY2]]|0.461|
|[[:human genes:t:ticrr|TICRR]]|0.461|
|[[:human genes:r:rrp15|RRP15]]|0.459|
|[[:human genes:d:disp2|DISP2]]|0.459|
|[[:human genes:t:timeless|TIMELESS]]|0.458|
|[[:human genes:s:snrnp70|SNRNP70]]|0.456|
|[[:human genes:s:slc4a1|SLC4A1]]|0.456|
|[[:human genes:r:riok2|RIOK2]]|0.456|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.455|
|[[:human genes:p:psma6|PSMA6]]|0.455|
|[[:human genes:s:sf3a1|SF3A1]]|0.454|
|[[:human genes:p:pole|POLE]]|0.454|
|[[:human genes:p:prpf3|PRPF3]]|0.454|
|[[:human genes:p:pola2|POLA2]]|0.454|
|[[:human genes:n:nsf|NSF]]|0.453|
|[[:human genes:a:aatf|AATF]]|0.452|
|[[:human genes:a:ahctf1|AHCTF1]]|0.452|
|[[:human genes:a:aamp|AAMP]]|0.452|
|[[:human genes:a:ankle1|ANKLE1]]|0.451|
|[[:human genes:n:nelfa|NELFA]]|0.45|
|[[:human genes:r:rnf113a|RNF113A]]|0.45|
|[[:human genes:x:xylt2|XYLT2]]|0.449|
|[[:human genes:h:hivep3|HIVEP3]]|0.448|
|[[:human genes:d:dhx38|DHX38]]|0.448|
|[[:human genes:v:vps54|VPS54]]|0.447|
|[[:human genes:c:col2a1|COL2A1]]|0.447|
|[[:human genes:i:ints5|INTS5]]|0.446|
|[[:human genes:n:nupl1|NUPL1]]|0.446|
|[[:human genes:b:brd2|BRD2]]|0.445|
|[[:human genes:p:polr2a|POLR2A]]|0.444|
|[[:human genes:c:ckap5|CKAP5]]|0.444|
|[[:human genes:r:rrm1|RRM1]]|0.443|
|[[:human genes:p:plk1|PLK1]]|0.443|
|[[:human genes:n:ncl|NCL]]|0.443|
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.443|
|[[:human genes:e:exosc6|EXOSC6]]|0.442|
|[[:human genes:c:cep192|CEP192]]|0.442|
|[[:human genes:g:gar1|GAR1]]|0.441|
|[[:human genes:d:dock6|DOCK6]]|0.441|
|[[:human genes:r:rpl8|RPL8]]|0.441|
|[[:human genes:a:atp6v1b2|ATP6V1B2]]|0.44|
|[[:human genes:i:ints6|INTS6]]|0.44|
|[[:human genes:s:smg7|SMG7]]|0.44|
|[[:human genes:e:exd1|EXD1]]|0.44|
|[[:human genes:n:napa|NAPA]]|0.439|
|[[:human genes:s:supt5h|SUPT5H]]|0.438|
|[[:human genes:t:tp53tg3d|TP53TG3D]]|0.438|
|[[:human genes:c:cbwd3|CBWD3]]|0.437|
|[[:human genes:v:vps28|VPS28]]|0.437|
|[[:human genes:a:akirin2|AKIRIN2]]|0.437|
|[[:human genes:n:nip7|NIP7]]|0.437|
|[[:human genes:e:exosc3|EXOSC3]]|0.437|
|[[:human genes:r:rrn3|RRN3]]|0.435|
|[[:human genes:z:zfand5|ZFAND5]]|0.434|
|[[:human genes:d:dido1|DIDO1]]|0.434|
|[[:human genes:l:lrr1|LRR1]]|0.434|
|[[:human genes:s:scaf1|SCAF1]]|0.434|
|[[:human genes:c:copz1|COPZ1]]|0.433|
|[[:human genes:s:sf3a2|SF3A2]]|0.433|
|[[:human genes:k:kif3c|KIF3C]]|0.433|
|[[:human genes:c:cbwd6|CBWD6]]|0.431|
|[[:human genes:c:cbwd5|CBWD5]]|0.43|
|[[:human genes:s:sap30bp|SAP30BP]]|0.43|
|[[:human genes:u:utp3|UTP3]]|0.43|
|[[:human genes:a:acsf2|ACSF2]]|0.429|
|[[:human genes:c:ccdc116|CCDC116]]|0.429|
|[[:human genes:c:cwc22|CWC22]]|0.428|
|[[:human genes:t:tsg101|TSG101]]|0.428|
|[[:human genes:p:psmd2|PSMD2]]|0.426|
|[[:human genes:p:psmb2|PSMB2]]|0.426|
|[[:human genes:a:atp6v1a|ATP6V1A]]|0.425|
|[[:human genes:p:psmd3|PSMD3]]|0.424|
|[[:human genes:t:tspy8|TSPY8]]|0.424|
|[[:human genes:e:exosc5|EXOSC5]]|0.423|
|[[:human genes:t:taf1|TAF1]]|0.423|
|[[:human genes:c:cdc6|CDC6]]|0.422|
|[[:human genes:s:sec13|SEC13]]|0.421|
|[[:human genes:l:loc643669|LOC643669]]|0.421|
|[[:human genes:m:mtch2|MTCH2]]|0.421|
|[[:human genes:s:strn|STRN]]|0.42|
|[[:human genes:h:hist1h2be|HIST1H2BE]]|0.42|
|[[:human genes:p:pla2g4f|PLA2G4F]]|0.419|
|[[:human genes:r:rps19|RPS19]]|0.419|
|[[:human genes:p:ppfia4|PPFIA4]]|0.418|
|[[:human genes:p:psmd7|PSMD7]]|0.418|
|[[:human genes:z:znf655|ZNF655]]|0.418|
|[[:human genes:p:ppie|PPIE]]|0.417|
|[[:human genes:s:smg1|SMG1]]|0.417|
|[[:human genes:n:nufip2|NUFIP2]]|0.416|
|[[:human genes:n:nop16|NOP16]]|0.416|
|[[:human genes:c:cdh24|CDH24]]|0.415|
|[[:human genes:p:psmc2|PSMC2]]|0.415|
|[[:human genes:t:tp53tg3b|TP53TG3B]]|0.415|
|[[:human genes:t:tp53tg3c|TP53TG3C]]|0.414|
|[[:human genes:t:tp53tg3|TP53TG3]]|0.414|
|[[:human genes:m:myb|MYB]]|0.413|
|[[:human genes:c:cdt1|CDT1]]|0.413|
|[[:human genes:o:ogdh|OGDH]]|0.413|
|[[:human genes:u:uspl1|USPL1]]|0.412|
|[[:human genes:r:rrp7a|RRP7A]]|0.411|
|[[:human genes:a:arcn1|ARCN1]]|0.411|
|[[:human genes:c:c19orf53|C19orf53]]|0.41|
|[[:human genes:t:tspy1|TSPY1]]|0.41|
|[[:human genes:g:gid4|GID4]]|0.409|
|[[:human genes:c:copa|COPA]]|0.409|
|[[:human genes:c:chaf1a|CHAF1A]]|0.409|
|[[:human genes:r:rpl38|RPL38]]|0.409|
|[[:human genes:c:chmp4b|CHMP4B]]|0.409|
|[[:human genes:r:rps19bp1|RPS19BP1]]|0.409|
|[[:human genes:t:terf1|TERF1]]|0.409|
|[[:human genes:t:twistnb|TWISTNB]]|0.409|
|[[:human genes:z:znf574|ZNF574]]|0.409|
|[[:human genes:k:krt78|KRT78]]|0.409|
|[[:human genes:s:sf3b5|SF3B5]]|0.408|
|[[:human genes:p:polr2f|POLR2F]]|0.408|
|[[:human genes:m:mbtd1|MBTD1]]|0.408|
|[[:human genes:r:rpl7l1|RPL7L1]]|0.408|
|[[:human genes:t:tyms|TYMS]]|0.408|
|[[:human genes:b:bid|BID]]|0.408|
|[[:human genes:a:akt1s1|AKT1S1]]|0.407|
|[[:human genes:w:wdr61|WDR61]]|0.407|
|[[:human genes:g:gosr2|GOSR2]]|0.407|
|[[:human genes:t:traip|TRAIP]]|0.406|
|[[:human genes:c:copb1|COPB1]]|0.406|
|[[:human genes:a:aaas|AAAS]]|0.406|
|[[:human genes:p:pds5b|PDS5B]]|0.406|
|[[:human genes:n:naaladl1|NAALADL1]]|0.405|
|[[:human genes:p:psmc1|PSMC1]]|0.405|
|[[:human genes:f:fam160a1|FAM160A1]]|0.405|
|[[:human genes:c:c14orf93|C14orf93]]|0.405|
|[[:human genes:r:rpp40|RPP40]]|0.405|
|[[:human genes:o:osbp|OSBP]]|0.404|
|[[:human genes:f:fcn2|FCN2]]|0.404|
|[[:human genes:s:supt6h|SUPT6H]]|0.404|
|[[:human genes:t:tpx2|TPX2]]|0.404|
|[[:human genes:a:atxn1|ATXN1]]|0.404|
|[[:human genes:p:pwp2|PWP2]]|0.404|
|[[:human genes:t:terf2|TERF2]]|0.404|
|[[:human genes:n:npipb11|NPIPB11]]|0.403|
|[[:human genes:p:polr2l|POLR2L]]|0.403|
|[[:human genes:c:cebpz|CEBPZ]]|0.403|
|[[:human genes:d:dimt1|DIMT1]]|0.403|
|[[:human genes:c:cdc45|CDC45]]|0.403|
|[[:human genes:s:ssh2|SSH2]]|0.402|
|[[:human genes:w:wdr87|WDR87]]|0.402|
|[[:human genes:d:ddt|DDT]]|0.402|
|[[:human genes:d:dgcr14|DGCR14]]|0.402|
|[[:human genes:s:syt9|SYT9]]|0.401|
|[[:human genes:f:fam25b|FAM25B]]|0.4|
|[[:human genes:d:diexf|DIEXF]]|0.4|
|[[:human genes:a:aqr|AQR]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 735/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|27/28|
|bone|26/26|
|breast|33/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|20/20|
|lung|75/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|21/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 368
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.24 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NARFL Expression in NALM6 Cells: 6.24'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>