======= NAT10 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: N/AT10
  * **<color #00a2e8>Official Name</color>**: N-acetyltransferase 10
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55226|55226]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H0A0|Q9H0A0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NAT10&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NAT10|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609221|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is an RNA cytidine acetyltransferase involved in histone acetylation, tRNA acetylation, the biosynthesis of 18S rRNA, and the enhancement of nuclear architecture and chromatin organization. [provided by RefSeq, Oct 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs (PubMed:25653167). Catalyzes the formation of N(4)-acetylcytidine (ac4C) at positions 1337 and 1842 in 18S rRNA (By similarity). Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis (PubMed:25653167). Catalyzes the formation of ac4C in serine and leucine tRNAs (By similarity). Requires the tRNA-binding adapter protein THUMBD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation (PubMed:25653167). Can acetylate both histones and microtubules. Histone acetylation may regulate transcription and mitotic chromosome de-condensation. Activates telomerase activity by stimulating the transcription of TERT, and may also regulate telomerase function by affecting the balance of telomerase subunit assembly, disassembly, and localization. Acetylates alpha-tubulin, which may affect microtubule stability and cell division (PubMed:14592445, PubMed:17631499, PubMed:18082603, PubMed:19303003). {ECO:0000250|UniProtKB:P53914, ECO:0000255|HAMAP-Rule:MF_03211, ECO:0000269|PubMed:14592445, ECO:0000269|PubMed:17631499, ECO:0000269|PubMed:18082603, ECO:0000269|PubMed:19303003, ECO:0000269|PubMed:25653167}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF1726|
|DUF699|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mRNA N-acetyltransferase activity|
|RNA acetylation|
|rRNA acetylation involved in maturation of SSU-rRNA|
|rRNA acetylation|
|tRNA acetylation|
|rRNA cytidine N-acetyltransferase activity|
|N-acetyltransferase activity|
|DNA polymerase binding|
|telomerase holoenzyme complex|
|negative regulation of telomere maintenance via telomerase|
|negative regulation of telomere maintenance via telomere lengthening|
|rRNA modification|
|negative regulation of telomere maintenance|
|negative regulation of DNA biosynthetic process|
|maturation of SSU-rRNA|
|regulation of telomere maintenance via telomerase|
|regulation of telomere maintenance via telomere lengthening|
|ribosomal small subunit biogenesis|
|regulation of telomere maintenance|
|tRNA modification|
|nuclear chromosome, telomeric region|
|regulation of DNA biosynthetic process|
|negative regulation of DNA metabolic process|
|positive regulation of translation|
|tRNA processing|
|negative regulation of chromosome organization|
|positive regulation of cellular amide metabolic process|
|midbody|
|RNA modification|
|tRNA metabolic process|
|rRNA processing|
|rRNA metabolic process|
|ribosome biogenesis|
|regulation of chromosome organization|
|regulation of translation|
|regulation of DNA metabolic process|
|negative regulation of organelle organization|
|ncRNA processing|
|regulation of cellular amide metabolic process|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|posttranscriptional regulation of gene expression|
|negative regulation of cellular component organization|
|nucleolus|
|RNA processing|
|regulation of organelle organization|
|negative regulation of cellular macromolecule biosynthetic process|
|RNA binding|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|ATP binding|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|positive regulation of cellular protein metabolic process|
|RNA metabolic process|
|positive regulation of protein metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|membrane|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|-2.17|
|[[:results:exp326|CCT251545 20μM R07 exp326]]|-2.16|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|-1.83|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|-1.73|
|[[:results:exp23|Nocodazole 0.02μM R00 exp23]]|1.73|
|[[:results:exp480|ETC-159 50μM R08 exp480]]|2.01|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.449|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 473/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|15/28|
|blood|19/28|
|bone|21/26|
|breast|19/33|
|central nervous system|47/56|
|cervix|3/4|
|colorectal|8/17|
|esophagus|8/13|
|fibroblast|0/1|
|gastric|10/16|
|kidney|14/21|
|liver|13/20|
|lung|52/75|
|lymphocyte|9/16|
|ovary|19/26|
|pancreas|15/24|
|peripheral nervous system|12/16|
|plasma cell|8/15|
|prostate|0/1|
|skin|17/24|
|soft tissue|6/9|
|thyroid|1/2|
|upper aerodigestive|7/22|
|urinary tract|23/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1132
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.74 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NAT10 Expression in NALM6 Cells: 7.74'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>