======= NCOA3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NCOA3
  * **<color #00a2e8>Official Name</color>**: nuclear receptor coactivator 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8202|8202]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y6Q9|Q9Y6Q9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NCOA3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NCOA3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601937|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a nuclear receptor coactivator that interacts with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has histone acetyltransferase activity and recruits p300/CBP-associated factor and CREB binding protein as part of a multisubunit coactivation complex. This protein is initially found in the cytoplasm but is translocated into the nucleus upon phosphorylation. Several transcript variants encoding different isoforms have been found for this gene. In addition, a polymorphic repeat region is found in the C-terminus of the encoded protein. [provided by RefSeq, Mar 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SRC-1|
|DUF1518|
|Nuc rec co-act|
|PAS|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|receptor transactivation|
|dedifferentiation|
|cell dedifferentiation|
|regulation of stem cell division|
|positive regulation of stem cell population maintenance|
|positive regulation of keratinocyte differentiation|
|nuclear receptor binding|
|positive regulation of epidermal cell differentiation|
|nuclear hormone receptor binding|
|regulation of stem cell population maintenance|
|thyroid hormone receptor binding|
|RNA polymerase II complex binding|
|disordered domain specific binding|
|positive regulation of signaling receptor activity|
|androgen receptor signaling pathway|
|cellular response to estradiol stimulus|
|positive regulation of epidermis development|
|regulation of keratinocyte differentiation|
|androgen receptor binding|
|histone acetyltransferase activity|
|positive regulation of epithelial cell differentiation|
|regulation of epidermal cell differentiation|
|nuclear receptor transcription coactivator activity|
|intracellular steroid hormone receptor signaling pathway|
|regulation of epidermis development|
|protein N-terminus binding|
|histone acetylation|
|internal peptidyl-lysine acetylation|
|steroid hormone mediated signaling pathway|
|peptidyl-lysine acetylation|
|internal protein amino acid acetylation|
|response to estradiol|
|regulation of epithelial cell differentiation|
|protein acetylation|
|intracellular receptor signaling pathway|
|regulation of cell division|
|hormone-mediated signaling pathway|
|regulation of signaling receptor activity|
|cellular response to steroid hormone stimulus|
|protein acylation|
|nuclear chromatin|
|transcription coactivator activity|
|peptidyl-lysine modification|
|response to steroid hormone|
|histone modification|
|covalent chromatin modification|
|protein heterodimerization activity|
|cellular response to lipid|
|cellular response to organic cyclic compound|
|protein-containing complex|
|cellular response to hormone stimulus|
|chromatin organization|
|response to lipid|
|peptidyl-amino acid modification|
|response to hormone|
|response to organic cyclic compound|
|positive regulation of cell differentiation|
|cellular response to oxygen-containing compound|
|chromosome organization|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|positive regulation of developmental process|
|response to endogenous stimulus|
|positive regulation of transcription, DNA-templated|
|response to oxygen-containing compound|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of cell differentiation|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|-1.95|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|-1.76|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3547
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.43 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NCOA3 Expression in NALM6 Cells: 6.43'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>