======= NCOR1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NCOR1
  * **<color #00a2e8>Official Name</color>**: nuclear receptor corepressor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9611|9611]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75376|O75376]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NCOR1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NCOR1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600849|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 17 and 20.[provided by RefSeq, Jun 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. {ECO:0000269|PubMed:14527417}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Myb DNA-binding|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of glycolytic process by negative regulation of transcription from RNA polymerase II promoter|
|regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter|
|regulation of carbohydrate catabolic process by regulation of transcription from RNA polymerase II promoter|
|regulation of glycolytic process by regulation of transcription from RNA polymerase II promoter|
|regulation of lipid transport by regulation of transcription from RNA polymerase II promoter|
|RNA polymerase II regulatory region DNA binding|
|negative regulation of production of miRNAs involved in gene silencing by miRNA|
|regulation of carbohydrate metabolic process by regulation of transcription from RNA polymerase II promoter|
|locomotor rhythm|
|Sin3 complex|
|negative regulation of gene silencing by miRNA|
|negative regulation of androgen receptor signaling pathway|
|negative regulation of gene silencing by RNA|
|negative regulation of posttranscriptional gene silencing|
|regulation of production of miRNAs involved in gene silencing by miRNA|
|regulation of production of small RNA involved in gene silencing by RNA|
|circadian behavior|
|rhythmic behavior|
|regulation of androgen receptor signaling pathway|
|nuclear hormone receptor binding|
|regulation of fatty acid transport|
|thyroid hormone receptor binding|
|negative regulation of JNK cascade|
|histone deacetylase complex|
|negative regulation of gene silencing|
|negative regulation of intracellular steroid hormone receptor signaling pathway|
|negative regulation of stress-activated MAPK cascade|
|negative regulation of stress-activated protein kinase signaling cascade|
|RNA polymerase II activating transcription factor binding|
|transcriptional repressor complex|
|regulation of organic acid transport|
|mitotic spindle|
|regulation of intracellular steroid hormone receptor signaling pathway|
|regulation of glycolytic process|
|regulation of gene silencing by miRNA|
|regulation of carbohydrate catabolic process|
|regulation of posttranscriptional gene silencing|
|regulation of gene silencing by RNA|
|regulation of anion transport|
|spindle assembly|
|regulation of lipid transport|
|histone deacetylase binding|
|regulation of purine nucleotide metabolic process|
|regulation of nucleotide metabolic process|
|regulation of ATP metabolic process|
|regulation of gene silencing|
|regulation of lipid localization|
|circadian rhythm|
|spindle organization|
|regulation of generation of precursor metabolites and energy|
|negative regulation of MAPK cascade|
|regulation of JNK cascade|
|locomotory behavior|
|regulation of carbohydrate metabolic process|
|transcription regulatory region DNA binding|
|regulation of stress-activated MAPK cascade|
|regulation of stress-activated protein kinase signaling cascade|
|nuclear chromatin|
|transcription corepressor activity|
|rhythmic process|
|chromatin binding|
|regulation of lipid metabolic process|
|negative regulation of protein phosphorylation|
|sequence-specific DNA binding|
|regulation of small molecule metabolic process|
|negative regulation of phosphorylation|
|microtubule cytoskeleton organization|
|transcription by RNA polymerase II|
|negative regulation of intracellular signal transduction|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|behavior|
|negative regulation of protein modification process|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|microtubule-based process|
|regulation of ion transport|
|chromatin organization|
|regulation of cellular response to stress|
|regulation of MAPK cascade|
|organelle assembly|
|negative regulation of transcription by RNA polymerase II|
|regulation of catabolic process|
|cell cycle process|
|negative regulation of cellular protein metabolic process|
|chromosome organization|
|nucleobase-containing compound biosynthetic process|
|negative regulation of protein metabolic process|
|cytoskeleton organization|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|organic cyclic compound biosynthetic process|
|negative regulation of RNA metabolic process|
|cell cycle|
|negative regulation of cell communication|
|negative regulation of signaling|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of phosphorylation|
|negative regulation of response to stimulus|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|macromolecule biosynthetic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
|positive regulation of gene expression|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp169|BH1 1μM R04 exp169]]|-2.77|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-2.77|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|-2.67|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|-2.25|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|-2.12|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|-2.11|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|-2.08|
|[[:results:exp277|Curcumin 6.5μM R06 exp277]]|-2.01|
|[[:results:exp302|35°C R06 exp302]]|-2|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|-1.93|
|[[:results:exp177|Apcin 25μM plus proTAME 2μM R04 exp177]]|-1.86|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|-1.86|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|-1.86|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-1.85|
|[[:results:exp467|CAY10603 0.55μM R08 exp467]]|-1.75|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|2.37|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|2.44|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|2.68|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|3.24|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|5.05|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hdac3|HDAC3]]|0.61|
|[[:human genes:p:prkaca|PRKACA]]|0.419|
|[[:human genes:k:kdsr|KDSR]]|0.412|
|[[:human genes:s:srp14|SRP14]]|0.411|
|[[:human genes:g:gnas|GNAS]]|0.403|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|1/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6498
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.64 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NCOR1 Expression in NALM6 Cells: 7.64'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>