======= NDRG4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NDRG4
  * **<color #00a2e8>Official Name</color>**: NDRG family member 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=65009|65009]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9ULP0|Q9ULP0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NDRG4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NDRG4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614463|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein that is required for cell cycle progression and survival in primary astrocytes and may be involved in the regulation of mitogenic signalling in vascular smooth muscles cells. Alternative splicing results in multiple transcripts encoding different isoforms.[provided by RefSeq, Jun 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Abhydrolase 6|
|Ndr|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cell projection membrane|
|regulation of endocytic recycling|
|negative regulation of platelet-derived growth factor receptor signaling pathway|
|cardiac muscle cell proliferation|
|cell migration involved in heart development|
|striated muscle cell proliferation|
|muscle cell proliferation|
|negative regulation of smooth muscle cell migration|
|regulation of platelet-derived growth factor receptor signaling pathway|
|cardiac muscle tissue growth|
|heart growth|
|negative regulation of smooth muscle cell proliferation|
|visual learning|
|visual behavior|
|heart looping|
|regulation of smooth muscle cell migration|
|vesicle docking|
|embryonic heart tube morphogenesis|
|determination of heart left/right asymmetry|
|embryonic heart tube development|
|associative learning|
|organ growth|
|determination of left/right symmetry|
|determination of bilateral symmetry|
|specification of symmetry|
|regulation of smooth muscle cell proliferation|
|learning|
|cardiac muscle tissue development|
|organelle localization by membrane tethering|
|membrane docking|
|basolateral plasma membrane|
|positive regulation of ERK1 and ERK2 cascade|
|heart morphogenesis|
|learning or memory|
|negative regulation of cell migration|
|negative regulation of cell motility|
|positive regulation of neuron projection development|
|striated muscle tissue development|
|embryonic organ morphogenesis|
|regulation of ERK1 and ERK2 cascade|
|muscle tissue development|
|cognition|
|epithelial tube morphogenesis|
|response to light stimulus|
|negative regulation of cellular component movement|
|negative regulation of locomotion|
|regulation of intracellular transport|
|positive regulation of neuron differentiation|
|positive regulation of cell projection organization|
|developmental growth|
|growth|
|morphogenesis of an epithelium|
|embryonic organ development|
|pattern specification process|
|response to radiation|
|positive regulation of neurogenesis|
|regulation of neuron projection development|
|heart development|
|positive regulation of nervous system development|
|positive regulation of cell development|
|positive regulation of MAPK cascade|
|regulation of vesicle-mediated transport|
|cell population proliferation|
|tissue morphogenesis|
|embryonic morphogenesis|
|behavior|
|organelle localization|
|tube morphogenesis|
|regulation of neuron differentiation|
|negative regulation of cell population proliferation|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|brain development|
|regulation of MAPK cascade|
|molecular function|
|head development|
|regulation of neurogenesis|
|tube development|
|regulation of cell migration|
|circulatory system development|
|regulation of cell motility|
|regulation of cellular localization|
|regulation of nervous system development|
|regulation of cell development|
|endoplasmic reticulum membrane|
|animal organ morphogenesis|
|cell migration|
|positive regulation of cell differentiation|
|embryo development|
|central nervous system development|
|regulation of locomotion|
|regulation of cellular component movement|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|positive regulation of phosphorylation|
|cell motility|
|localization of cell|
|epithelium development|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|response to abiotic stimulus|
|positive regulation of cellular component organization|
|positive regulation of protein modification process|
|mitochondrion|
|negative regulation of signal transduction|
|locomotion|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|nervous system process|
|regulation of protein phosphorylation|
|generation of neurons|
|movement of cell or subcellular component|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|neurogenesis|
|positive regulation of signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
|vesicle-mediated transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|-2.27|
|[[:results:exp150|SGC0649 7μM R03 exp150]]|-1.97|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|-1.92|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|-1.76|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|-1.72|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|-1.71|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|2.32|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:ruvbl2|RUVBL2]]|0.469|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6468
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.7 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NDRG4 Expression in NALM6 Cells: 3.7'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>