======= NDUFA13 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NDUFA13
  * **<color #00a2e8>Official Name</color>**: N/ADH:ubiquinone oxidoreductase subunit A13
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51079|51079]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9P0J0|Q9P0J0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NDUFA13&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NDUFA13|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609435|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain. The protein is required for complex I assembly and electron transfer activity. The protein binds the signal transducers and activators of transcription 3 (STAT3) transcription factor, and can function as a tumor suppressor. The human protein purified from mitochondria migrates at approximately 16 kDa. Transcripts originating from an upstream promoter and capable of expressing a protein with a longer N-terminus have been found, but their biological validity has not been determined. [provided by RefSeq, Oct 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis (PubMed:27626371). Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (PubMed:27626371). Involved in the interferon/all-trans-retinoic acid (IFN/RA) induced cell death. This apoptotic activity is inhibited by interaction with viral IRF1. Prevents the transactivation of STAT3 target genes. May play a role in CARD15-mediated innate mucosal responses and serve to regulate intestinal epithelial cell responses to microbes (PubMed:15753091). {ECO:0000269|PubMed:12628925, ECO:0000269|PubMed:12867595, ECO:0000269|PubMed:15753091, ECO:0000269|PubMed:27626371}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|GRIM-19|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein insertion into mitochondrial inner membrane|
|NADH dehydrogenase activity|
|mitochondrial respirasome|
|establishment of protein localization to mitochondrial membrane|
|cellular response to interferon-beta|
|protein insertion into mitochondrial membrane|
|response to interferon-beta|
|protein insertion into membrane|
|inner mitochondrial membrane organization|
|NADH dehydrogenase (ubiquinone) activity|
|mitochondrial electron transport, NADH to ubiquinone|
|mitochondrial respiratory chain complex I|
|protein targeting to mitochondrion|
|NADH dehydrogenase complex assembly|
|mitochondrial respiratory chain complex I assembly|
|cellular response to retinoic acid|
|establishment of protein localization to mitochondrion|
|protein localization to mitochondrion|
|mitochondrial ATP synthesis coupled electron transport|
|ATP synthesis coupled electron transport|
|negative regulation of intrinsic apoptotic signaling pathway|
|extrinsic apoptotic signaling pathway|
|mitochondrial respiratory chain complex assembly|
|mitochondrial membrane|
|response to retinoic acid|
|respiratory electron transport chain|
|reactive oxygen species metabolic process|
|oxidative phosphorylation|
|mitochondrial membrane organization|
|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|positive regulation of cysteine-type endopeptidase activity|
|regulation of intrinsic apoptotic signaling pathway|
|cellular respiration|
|positive regulation of endopeptidase activity|
|electron transport chain|
|negative regulation of cell growth|
|positive regulation of peptidase activity|
|ATP metabolic process|
|cellular response to acid chemical|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|mitochondrial transport|
|positive regulation of protein catabolic process|
|negative regulation of apoptotic signaling pathway|
|energy derivation by oxidation of organic compounds|
|regulation of cysteine-type endopeptidase activity|
|negative regulation of growth|
|establishment of protein localization to membrane|
|apoptotic signaling pathway|
|response to acid chemical|
|protein targeting|
|positive regulation of proteolysis|
|regulation of protein catabolic process|
|mitochondrial inner membrane|
|regulation of apoptotic signaling pathway|
|regulation of cell growth|
|regulation of endopeptidase activity|
|generation of precursor metabolites and energy|
|establishment of protein localization to organelle|
|positive regulation of catabolic process|
|mitochondrion organization|
|regulation of peptidase activity|
|protein localization to membrane|
|negative regulation of intracellular signal transduction|
|cellular response to lipid|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|regulation of growth|
|positive regulation of cell death|
|regulation of proteolysis|
|protein localization to organelle|
|positive regulation of hydrolase activity|
|cellular protein-containing complex assembly|
|membrane organization|
|response to lipid|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|apoptotic process|
|oxidation-reduction process|
|intracellular protein transport|
|negative regulation of cell death|
|regulation of catabolic process|
|cellular response to cytokine stimulus|
|programmed cell death|
|cellular response to oxygen-containing compound|
|cell death|
|response to cytokine|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|mitochondrion|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|phosphorylation|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|negative regulation of cellular macromolecule biosynthetic process|
|positive regulation of catalytic activity|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|ATP binding|
|protein transport|
|negative regulation of cellular biosynthetic process|
|intracellular transport|
|peptide transport|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|regulation of programmed cell death|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|negative regulation of response to stimulus|
|regulation of cell death|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of molecular function|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp447|Amiloride 100μM R08 exp447]]|1.72|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|1.79|
|[[:results:exp59|UMK57 1μM R01 exp59]]|1.83|
|[[:results:exp360|Genistein 15μM R07 exp360]]|1.85|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|1.85|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|1.89|
|[[:results:exp455|Benzoate 10000μM R08 exp455]]|1.93|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|1.98|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|2|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|2.1|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|2.11|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|2.15|
|[[:results:exp490|Hydroxychloroquine 30μM R08 exp490]]|2.17|
|[[:results:exp495|IWR1 50μM R08 exp495]]|2.19|
|[[:results:exp211|AICAR 240μM R05 exp211]]|2.22|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|2.44|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|2.46|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|2.55|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|2.79|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|3.27|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:ndufc2|NDUFC2]]|0.589|
|[[:human genes:n:ndufa2|NDUFA2]]|0.567|
|[[:human genes:n:ndufa1|NDUFA1]]|0.55|
|[[:human genes:n:ndufs2|NDUFS2]]|0.538|
|[[:human genes:n:ndufa11|NDUFA11]]|0.535|
|[[:human genes:n:ndufb4|NDUFB4]]|0.533|
|[[:human genes:n:ndufa9|NDUFA9]]|0.533|
|[[:human genes:n:ndufb11|NDUFB11]]|0.525|
|[[:human genes:a:acad9|ACAD9]]|0.518|
|[[:human genes:n:ndufb9|NDUFB9]]|0.515|
|[[:human genes:n:nubpl|NUBPL]]|0.513|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.503|
|[[:human genes:n:ndufs8|NDUFS8]]|0.501|
|[[:human genes:n:ndufb7|NDUFB7]]|0.5|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.499|
|[[:human genes:n:ndufa8|NDUFA8]]|0.497|
|[[:human genes:g:grsf1|GRSF1]]|0.496|
|[[:human genes:n:ndufc1|NDUFC1]]|0.496|
|[[:human genes:m:mto1|MTO1]]|0.49|
|[[:human genes:n:ndufa3|NDUFA3]]|0.485|
|[[:human genes:n:ndufv1|NDUFV1]]|0.476|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.476|
|[[:human genes:n:ndufs1|NDUFS1]]|0.468|
|[[:human genes:n:ndufs5|NDUFS5]]|0.467|
|[[:human genes:n:ndufb8|NDUFB8]]|0.466|
|[[:human genes:n:ndufa10|NDUFA10]]|0.462|
|[[:human genes:n:ndufa6|NDUFA6]]|0.457|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.456|
|[[:human genes:n:ndufs3|NDUFS3]]|0.451|
|[[:human genes:n:ndufs7|NDUFS7]]|0.444|
|[[:human genes:n:noa1|NOA1]]|0.443|
|[[:human genes:e:ecsit|ECSIT]]|0.443|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.441|
|[[:human genes:n:ndufv2|NDUFV2]]|0.441|
|[[:human genes:t:tfb1m|TFB1M]]|0.43|
|[[:human genes:n:ndufaf6|NDUFAF6]]|0.429|
|[[:human genes:p:polg2|POLG2]]|0.427|
|[[:human genes:m:mrpl45|MRPL45]]|0.427|
|[[:human genes:n:ndufb2|NDUFB2]]|0.425|
|[[:human genes:s:slc25a51|SLC25A51]]|0.422|
|[[:human genes:m:mrps27|MRPS27]]|0.419|
|[[:human genes:t:tmem261|TMEM261]]|0.418|
|[[:human genes:m:mrpl43|MRPL43]]|0.418|
|[[:human genes:m:mrp63|MRP63]]|0.414|
|[[:human genes:r:rnmtl1|RNMTL1]]|0.414|
|[[:human genes:m:mrps21|MRPS21]]|0.413|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.409|
|[[:human genes:n:ndufa5|NDUFA5]]|0.409|
|[[:human genes:m:mtif2|MTIF2]]|0.408|
|[[:human genes:w:wbscr16|WBSCR16]]|0.405|
|[[:human genes:m:mrpl3|MRPL3]]|0.403|
|[[:human genes:m:mettl17|METTL17]]|0.403|
|[[:human genes:c:c10orf2|C10orf2]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 248
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.36 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NDUFA13 Expression in NALM6 Cells: 5.36'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>