======= NDUFA6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NDUFA6
  * **<color #00a2e8>Official Name</color>**: N/ADH:ubiquinone oxidoreductase subunit A6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4700|4700]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P56556|P56556]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NDUFA6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NDUFA6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602138|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the LYR family of proteins that contain a highly conserved tripeptide (LYR) motif near the N-terminus. The encoded protein is an accessory subunit of NADH: ubiquinone oxidorerductase (Complex I), which is the largest enzyme of the mitochondrial membrane respiratory chain. Complex I functions in electron transfer from NADH to the respiratory chain. [provided by RefSeq, Oct 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. {ECO:0000269|PubMed:27626371}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Complex1 LYR|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|NADH dehydrogenase (ubiquinone) activity|
|mitochondrial electron transport, NADH to ubiquinone|
|mitochondrial respiratory chain complex I|
|mitochondrial respiratory chain complex I assembly|
|NADH dehydrogenase complex assembly|
|mitochondrial ATP synthesis coupled electron transport|
|ATP synthesis coupled electron transport|
|mitochondrial respiratory chain complex assembly|
|mitochondrial membrane|
|respiratory electron transport chain|
|oxidative phosphorylation|
|cellular respiration|
|electron transport chain|
|ATP metabolic process|
|energy derivation by oxidation of organic compounds|
|response to oxidative stress|
|mitochondrial inner membrane|
|generation of precursor metabolites and energy|
|mitochondrion organization|
|cellular protein-containing complex assembly|
|oxidation-reduction process|
|phosphorylation|
|protein-containing complex assembly|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp360|Genistein 15μM R07 exp360]]|1.73|
|[[:results:exp50|Nicotinamide 2000μM R01 exp50]]|1.75|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|1.85|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|1.99|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|2.43|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|2.53|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|2.64|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|2.73|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:ndufa2|NDUFA2]]|0.622|
|[[:human genes:n:ndufa11|NDUFA11]]|0.607|
|[[:human genes:n:ndufs2|NDUFS2]]|0.584|
|[[:human genes:n:ndufa3|NDUFA3]]|0.574|
|[[:human genes:n:ndufa1|NDUFA1]]|0.572|
|[[:human genes:n:ndufb11|NDUFB11]]|0.569|
|[[:human genes:n:ndufb9|NDUFB9]]|0.566|
|[[:human genes:n:nubpl|NUBPL]]|0.557|
|[[:human genes:e:ecsit|ECSIT]]|0.552|
|[[:human genes:n:ndufa8|NDUFA8]]|0.535|
|[[:human genes:n:ndufs5|NDUFS5]]|0.531|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.531|
|[[:human genes:n:ndufv2|NDUFV2]]|0.523|
|[[:human genes:n:ndufc2|NDUFC2]]|0.513|
|[[:human genes:n:ndufc1|NDUFC1]]|0.512|
|[[:human genes:n:ndufs8|NDUFS8]]|0.508|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.504|
|[[:human genes:m:mto1|MTO1]]|0.503|
|[[:human genes:g:grsf1|GRSF1]]|0.498|
|[[:human genes:n:ndufb6|NDUFB6]]|0.496|
|[[:human genes:n:ndufb5|NDUFB5]]|0.494|
|[[:human genes:a:acad9|ACAD9]]|0.489|
|[[:human genes:n:ndufb7|NDUFB7]]|0.484|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.476|
|[[:human genes:n:ndufaf6|NDUFAF6]]|0.474|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.473|
|[[:human genes:n:ndufb2|NDUFB2]]|0.471|
|[[:human genes:n:ndufs7|NDUFS7]]|0.466|
|[[:human genes:n:ndufaf1|NDUFAF1]]|0.459|
|[[:human genes:n:ndufa13|NDUFA13]]|0.457|
|[[:human genes:p:pet117|PET117]]|0.457|
|[[:human genes:n:ndufb10|NDUFB10]]|0.444|
|[[:human genes:c:c12orf65|C12orf65]]|0.443|
|[[:human genes:p:pet112|PET112]]|0.44|
|[[:human genes:f:fastkd2|FASTKD2]]|0.44|
|[[:human genes:p:polg2|POLG2]]|0.435|
|[[:human genes:f:ftsj2|FTSJ2]]|0.434|
|[[:human genes:f:foxred1|FOXRED1]]|0.43|
|[[:human genes:n:ndufa9|NDUFA9]]|0.429|
|[[:human genes:m:mrps21|MRPS21]]|0.429|
|[[:human genes:c:c17orf89|C17orf89]]|0.427|
|[[:human genes:r:rpusd3|RPUSD3]]|0.427|
|[[:human genes:g:gfm1|GFM1]]|0.427|
|[[:human genes:m:malsu1|MALSU1]]|0.426|
|[[:human genes:m:mrpl44|MRPL44]]|0.426|
|[[:human genes:n:ndufb8|NDUFB8]]|0.425|
|[[:human genes:t:tmem261|TMEM261]]|0.424|
|[[:human genes:m:mtg1|MTG1]]|0.42|
|[[:human genes:m:mrpl45|MRPL45]]|0.418|
|[[:human genes:g:glrx5|GLRX5]]|0.417|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.417|
|[[:human genes:r:rmnd1|RMND1]]|0.415|
|[[:human genes:w:wbscr16|WBSCR16]]|0.415|
|[[:human genes:n:ndufaf5|NDUFAF5]]|0.415|
|[[:human genes:m:mrpl17|MRPL17]]|0.415|
|[[:human genes:n:ndufs3|NDUFS3]]|0.414|
|[[:human genes:n:ndufb4|NDUFB4]]|0.412|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.409|
|[[:human genes:n:ndufa10|NDUFA10]]|0.406|
|[[:human genes:t:trub2|TRUB2]]|0.405|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.404|
|[[:human genes:c:chchd1|CHCHD1]]|0.404|
|[[:human genes:m:mrpl21|MRPL21]]|0.404|
|[[:human genes:a:aifm1|AIFM1]]|0.402|
|[[:human genes:g:gtpbp8|GTPBP8]]|0.401|
|[[:human genes:n:ndufa5|NDUFA5]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 59/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|3/28|
|blood|2/28|
|bone|2/26|
|breast|7/33|
|central nervous system|3/56|
|cervix|1/4|
|colorectal|2/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|3/16|
|kidney|1/21|
|liver|3/20|
|lung|6/75|
|lymphocyte|0/16|
|ovary|1/26|
|pancreas|1/24|
|peripheral nervous system|0/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|3/24|
|soft tissue|2/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|2/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2160
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.42 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NDUFA6 Expression in NALM6 Cells: 5.42'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>