======= NDUFAF6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NDUFAF6
  * **<color #00a2e8>Official Name</color>**: N/ADH:ubiquinone oxidoreductase complex assembly factor 6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=137682|137682]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q330K2|Q330K2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NDUFAF6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NDUFAF6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612392|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein that localizes to mitochondria and contains a predicted phytoene synthase domain. The encoded protein plays an important role in the assembly of complex I (NADH-ubiquinone oxidoreductase) of the mitochondrial respiratory chain through regulation of subunit ND1 biogenesis. Mutations in this gene are associated with complex I enzymatic deficiency. [provided by RefSeq, Nov 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I) at early stages. May play a role in the biogenesis of MT-ND1. {ECO:0000269|PubMed:18614015, ECO:0000269|PubMed:22019594}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SQS PSY|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial respiratory chain complex I assembly|
|NADH dehydrogenase complex assembly|
|mitochondrial respiratory chain complex assembly|
|mitochondrial inner membrane|
|mitochondrion organization|
|cellular protein-containing complex assembly|
|mitochondrion|
|protein-containing complex assembly|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|1.7|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|1.72|
|[[:results:exp307|Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307]]|1.75|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|1.79|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|1.8|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|1.81|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|1.82|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|1.83|
|[[:results:exp534|Trientine 500μM R08 exp534]]|1.86|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|1.88|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|1.94|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|1.97|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|2|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|2.02|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|2.08|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|2.09|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|2.12|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|2.18|
|[[:results:exp433|LJH685 50μM R08 exp433]]|2.25|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|2.26|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|2.38|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|2.44|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|2.52|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|3.39|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|3.53|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:acad9|ACAD9]]|0.654|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.647|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.636|
|[[:human genes:n:ndufs2|NDUFS2]]|0.634|
|[[:human genes:n:ndufa1|NDUFA1]]|0.633|
|[[:human genes:g:grsf1|GRSF1]]|0.631|
|[[:human genes:n:ndufa2|NDUFA2]]|0.629|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.627|
|[[:human genes:m:mto1|MTO1]]|0.625|
|[[:human genes:n:nubpl|NUBPL]]|0.621|
|[[:human genes:n:ndufs8|NDUFS8]]|0.617|
|[[:human genes:n:ndufs5|NDUFS5]]|0.617|
|[[:human genes:n:ndufb9|NDUFB9]]|0.613|
|[[:human genes:n:ndufb11|NDUFB11]]|0.599|
|[[:human genes:n:ndufa3|NDUFA3]]|0.594|
|[[:human genes:n:ndufb7|NDUFB7]]|0.58|
|[[:human genes:n:ndufc1|NDUFC1]]|0.574|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.57|
|[[:human genes:n:ndufs7|NDUFS7]]|0.567|
|[[:human genes:n:ndufa8|NDUFA8]]|0.563|
|[[:human genes:n:ndufc2|NDUFC2]]|0.562|
|[[:human genes:n:ndufaf5|NDUFAF5]]|0.562|
|[[:human genes:n:ndufa11|NDUFA11]]|0.554|
|[[:human genes:e:ecsit|ECSIT]]|0.548|
|[[:human genes:n:ndufb5|NDUFB5]]|0.541|
|[[:human genes:f:fastkd2|FASTKD2]]|0.54|
|[[:human genes:p:prepl|PREPL]]|0.533|
|[[:human genes:m:mcat|MCAT]]|0.529|
|[[:human genes:f:foxred1|FOXRED1]]|0.529|
|[[:human genes:n:ndufv1|NDUFV1]]|0.527|
|[[:human genes:n:ndufs3|NDUFS3]]|0.518|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.518|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.518|
|[[:human genes:r:rpusd3|RPUSD3]]|0.507|
|[[:human genes:n:ndufv2|NDUFV2]]|0.507|
|[[:human genes:m:mterfd1|MTERFD1]]|0.506|
|[[:human genes:n:ndufb10|NDUFB10]]|0.5|
|[[:human genes:a:atp5sl|ATP5SL]]|0.499|
|[[:human genes:p:pet117|PET117]]|0.498|
|[[:human genes:f:ftsj2|FTSJ2]]|0.497|
|[[:human genes:l:lars2|LARS2]]|0.495|
|[[:human genes:c:chchd1|CHCHD1]]|0.494|
|[[:human genes:n:ndufb2|NDUFB2]]|0.492|
|[[:human genes:n:ndufaf1|NDUFAF1]]|0.49|
|[[:human genes:n:ndufb6|NDUFB6]]|0.481|
|[[:human genes:n:ndufb4|NDUFB4]]|0.48|
|[[:human genes:p:pet112|PET112]]|0.479|
|[[:human genes:g:gfm2|GFM2]]|0.478|
|[[:human genes:s:ssbp1|SSBP1]]|0.478|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.477|
|[[:human genes:q:qrsl1|QRSL1]]|0.476|
|[[:human genes:n:ndufs1|NDUFS1]]|0.475|
|[[:human genes:n:ndufa6|NDUFA6]]|0.474|
|[[:human genes:h:hmgxb3|HMGXB3]]|0.471|
|[[:human genes:m:mrps25|MRPS25]]|0.468|
|[[:human genes:m:mtif2|MTIF2]]|0.467|
|[[:human genes:c:cars2|CARS2]]|0.467|
|[[:human genes:t:tfb1m|TFB1M]]|0.467|
|[[:human genes:i:iba57|IBA57]]|0.465|
|[[:human genes:r:rmnd1|RMND1]]|0.465|
|[[:human genes:c:c1qbp|C1QBP]]|0.464|
|[[:human genes:n:ndufb8|NDUFB8]]|0.464|
|[[:human genes:c:c12orf65|C12orf65]]|0.463|
|[[:human genes:n:ndufa10|NDUFA10]]|0.461|
|[[:human genes:e:eral1|ERAL1]]|0.461|
|[[:human genes:p:pde12|PDE12]]|0.459|
|[[:human genes:m:mtg1|MTG1]]|0.459|
|[[:human genes:c:c17orf89|C17orf89]]|0.459|
|[[:human genes:p:polg|POLG]]|0.458|
|[[:human genes:m:malsu1|MALSU1]]|0.456|
|[[:human genes:c:clpp|CLPP]]|0.454|
|[[:human genes:m:mrpl44|MRPL44]]|0.45|
|[[:human genes:m:mrpl22|MRPL22]]|0.446|
|[[:human genes:c:coq2|COQ2]]|0.446|
|[[:human genes:p:polg2|POLG2]]|0.445|
|[[:human genes:m:mettl17|METTL17]]|0.444|
|[[:human genes:m:mrps5|MRPS5]]|0.443|
|[[:human genes:c:coq7|COQ7]]|0.443|
|[[:human genes:t:tmem261|TMEM261]]|0.436|
|[[:human genes:s:sfxn4|SFXN4]]|0.435|
|[[:human genes:d:dap3|DAP3]]|0.432|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.431|
|[[:human genes:n:ndufa13|NDUFA13]]|0.429|
|[[:human genes:m:mrps21|MRPS21]]|0.427|
|[[:human genes:m:mrpl13|MRPL13]]|0.427|
|[[:human genes:m:mrp63|MRP63]]|0.419|
|[[:human genes:c:cluh|CLUH]]|0.418|
|[[:human genes:w:wars2|WARS2]]|0.418|
|[[:human genes:g:gtpbp6|GTPBP6]]|0.418|
|[[:human genes:m:mrpl45|MRPL45]]|0.417|
|[[:human genes:w:wbscr16|WBSCR16]]|0.415|
|[[:human genes:t:tsfm|TSFM]]|0.414|
|[[:human genes:m:mrpl21|MRPL21]]|0.412|
|[[:human genes:g:glrx5|GLRX5]]|0.411|
|[[:human genes:g:gfm1|GFM1]]|0.41|
|[[:human genes:x:xpnpep3|XPNPEP3]]|0.41|
|[[:human genes:n:nfu1|NFU1]]|0.408|
|[[:human genes:n:noa1|NOA1]]|0.407|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.406|
|[[:human genes:g:gtpbp8|GTPBP8]]|0.405|
|[[:human genes:n:nars2|NARS2]]|0.404|
|[[:human genes:n:ndufa9|NDUFA9]]|0.404|
|[[:human genes:n:nsun4|NSUN4]]|0.404|
|[[:human genes:a:aifm1|AIFM1]]|0.403|
|[[:human genes:n:ndufa5|NDUFA5]]|0.402|
|[[:human genes:d:ddx28|DDX28]]|0.402|
|[[:human genes:m:mrpl1|MRPL1]]|0.401|
|[[:human genes:s:selrc1|SELRC1]]|0.4|
|[[:human genes:m:mrps27|MRPS27]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1362
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.11 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NDUFAF6 Expression in NALM6 Cells: 5.11'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>