======= NDUFAF7 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NDUFAF7
  * **<color #00a2e8>Official Name</color>**: N/ADH:ubiquinone oxidoreductase complex assembly factor 7
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55471|55471]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q7L592|Q7L592]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NDUFAF7&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NDUFAF7|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615898|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes an assembly factor protein which helps in the assembly and stabilization of Complex I, a large multi-subunit enzyme in the mitochondrial respiratory chain. Complex I is involved in several physiological activities in the cell, including metabolite transport and ATP synthesis. The encoded protein is a methyltransferase which methylates Arg85 of a subunit of Complex I in the early stages of its assembly. A pseudogene related to this gene is located on chromosome 8. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I) (PubMed:20406883, PubMed:24089531, PubMed:24838397). Acts by mediating symmetric dimethylation of 'Arg-118' of NDUFS2 after it assembles into the complex I, stabilizing the early intermediate complex (PubMed:24089531). {ECO:0000269|PubMed:20406883, ECO:0000269|PubMed:24089531, ECO:0000269|PubMed:24838397}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF185|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein-arginine omega-N symmetric methyltransferase activity|
|peptidyl-arginine methylation, to symmetrical-dimethyl arginine|
|peptidyl-arginine omega-N-methylation|
|peptidyl-arginine N-methylation|
|peptidyl-arginine methylation|
|peptidyl-arginine modification|
|methyltransferase activity|
|mitochondrial respiratory chain complex I assembly|
|NADH dehydrogenase complex assembly|
|mitochondrial respiratory chain complex assembly|
|protein methylation|
|protein alkylation|
|macromolecule methylation|
|methylation|
|enzyme binding|
|mitochondrial matrix|
|mitochondrion organization|
|cellular protein-containing complex assembly|
|peptidyl-amino acid modification|
|mitochondrion|
|protein-containing complex assembly|
|extracellular space|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|1.72|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|1.73|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|1.81|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|1.81|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|1.82|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|1.84|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|1.86|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|1.87|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|1.87|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|1.88|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|1.94|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|1.94|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|1.94|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|2.04|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|2.06|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|2.08|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|2.09|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|2.22|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|2.23|
|[[:results:exp143|Phenformin 20μM R03 exp143]]|2.28|
|[[:results:exp534|Trientine 500μM R08 exp534]]|2.5|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|2.51|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|2.53|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|2.58|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|2.65|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|2.88|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|3.16|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|3.56|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:ndufa3|NDUFA3]]|0.737|
|[[:human genes:n:ndufa2|NDUFA2]]|0.729|
|[[:human genes:n:ndufb11|NDUFB11]]|0.727|
|[[:human genes:n:ndufs2|NDUFS2]]|0.689|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.687|
|[[:human genes:n:ndufa1|NDUFA1]]|0.684|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.683|
|[[:human genes:n:ndufc2|NDUFC2]]|0.668|
|[[:human genes:n:nubpl|NUBPL]]|0.663|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.653|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.65|
|[[:human genes:g:grsf1|GRSF1]]|0.644|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.643|
|[[:human genes:l:lars2|LARS2]]|0.641|
|[[:human genes:n:ndufb5|NDUFB5]]|0.638|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.637|
|[[:human genes:y:yars2|YARS2]]|0.637|
|[[:human genes:g:gfm1|GFM1]]|0.636|
|[[:human genes:m:mto1|MTO1]]|0.635|
|[[:human genes:n:ndufs5|NDUFS5]]|0.633|
|[[:human genes:n:ndufb9|NDUFB9]]|0.632|
|[[:human genes:c:c12orf65|C12orf65]]|0.629|
|[[:human genes:n:ndufaf6|NDUFAF6]]|0.627|
|[[:human genes:n:ndufs7|NDUFS7]]|0.626|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.625|
|[[:human genes:s:selrc1|SELRC1]]|0.625|
|[[:human genes:n:ndufa11|NDUFA11]]|0.622|
|[[:human genes:a:acad9|ACAD9]]|0.621|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.613|
|[[:human genes:n:nars2|NARS2]]|0.61|
|[[:human genes:c:c17orf89|C17orf89]]|0.609|
|[[:human genes:t:tars2|TARS2]]|0.607|
|[[:human genes:m:mrpl21|MRPL21]]|0.604|
|[[:human genes:n:ndufc1|NDUFC1]]|0.602|
|[[:human genes:n:ndufa8|NDUFA8]]|0.601|
|[[:human genes:r:rbfa|RBFA]]|0.598|
|[[:human genes:m:mrp63|MRP63]]|0.596|
|[[:human genes:m:mrps6|MRPS6]]|0.594|
|[[:human genes:s:sco2|SCO2]]|0.594|
|[[:human genes:c:coq2|COQ2]]|0.591|
|[[:human genes:a:aifm1|AIFM1]]|0.59|
|[[:human genes:m:mrps21|MRPS21]]|0.589|
|[[:human genes:d:dap3|DAP3]]|0.584|
|[[:human genes:g:gfm2|GFM2]]|0.584|
|[[:human genes:m:mrpl45|MRPL45]]|0.581|
|[[:human genes:e:ecsit|ECSIT]]|0.581|
|[[:human genes:m:mrps5|MRPS5]]|0.579|
|[[:human genes:p:polg|POLG]]|0.579|
|[[:human genes:f:foxred1|FOXRED1]]|0.578|
|[[:human genes:m:mrps34|MRPS34]]|0.577|
|[[:human genes:n:ndufb6|NDUFB6]]|0.576|
|[[:human genes:p:pet117|PET117]]|0.575|
|[[:human genes:d:dars2|DARS2]]|0.574|
|[[:human genes:c:coq7|COQ7]]|0.569|
|[[:human genes:a:atp5sl|ATP5SL]]|0.567|
|[[:human genes:m:mrpl47|MRPL47]]|0.566|
|[[:human genes:m:mrps16|MRPS16]]|0.566|
|[[:human genes:f:ftsj2|FTSJ2]]|0.566|
|[[:human genes:q:qrsl1|QRSL1]]|0.566|
|[[:human genes:c:c10orf2|C10orf2]]|0.565|
|[[:human genes:n:ndufv1|NDUFV1]]|0.565|
|[[:human genes:p:polg2|POLG2]]|0.565|
|[[:human genes:r:rpusd3|RPUSD3]]|0.564|
|[[:human genes:p:pars2|PARS2]]|0.564|
|[[:human genes:f:fastkd2|FASTKD2]]|0.563|
|[[:human genes:m:mrpl53|MRPL53]]|0.563|
|[[:human genes:t:tefm|TEFM]]|0.562|
|[[:human genes:b:bcs1l|BCS1L]]|0.562|
|[[:human genes:e:ears2|EARS2]]|0.56|
|[[:human genes:v:vars2|VARS2]]|0.56|
|[[:human genes:m:mrpl23|MRPL23]]|0.557|
|[[:human genes:n:ndufa10|NDUFA10]]|0.556|
|[[:human genes:w:wbscr16|WBSCR16]]|0.555|
|[[:human genes:c:chchd1|CHCHD1]]|0.553|
|[[:human genes:i:iba57|IBA57]]|0.551|
|[[:human genes:m:mrps14|MRPS14]]|0.551|
|[[:human genes:n:ndufs8|NDUFS8]]|0.549|
|[[:human genes:t:tmem261|TMEM261]]|0.548|
|[[:human genes:c:cars2|CARS2]]|0.543|
|[[:human genes:r:rpusd4|RPUSD4]]|0.543|
|[[:human genes:m:mettl17|METTL17]]|0.542|
|[[:human genes:m:mrpl15|MRPL15]]|0.541|
|[[:human genes:g:gatc|GATC]]|0.539|
|[[:human genes:c:cox16|COX16]]|0.537|
|[[:human genes:m:mrpl44|MRPL44]]|0.537|
|[[:human genes:n:ndufaf5|NDUFAF5]]|0.535|
|[[:human genes:m:mrps25|MRPS25]]|0.531|
|[[:human genes:n:ndufa6|NDUFA6]]|0.531|
|[[:human genes:t:tfb1m|TFB1M]]|0.53|
|[[:human genes:t:tufm|TUFM]]|0.529|
|[[:human genes:p:pnpt1|PNPT1]]|0.529|
|[[:human genes:n:ndufa5|NDUFA5]]|0.527|
|[[:human genes:r:rars2|RARS2]]|0.525|
|[[:human genes:m:mrps24|MRPS24]]|0.522|
|[[:human genes:c:cox15|COX15]]|0.52|
|[[:human genes:s:sars2|SARS2]]|0.52|
|[[:human genes:n:ndufb2|NDUFB2]]|0.517|
|[[:human genes:n:nfu1|NFU1]]|0.516|
|[[:human genes:n:ndufs1|NDUFS1]]|0.514|
|[[:human genes:m:mtg1|MTG1]]|0.514|
|[[:human genes:m:mrps18a|MRPS18A]]|0.514|
|[[:human genes:c:cox6c|COX6C]]|0.513|
|[[:human genes:m:mterfd1|MTERFD1]]|0.513|
|[[:human genes:f:fastkd5|FASTKD5]]|0.512|
|[[:human genes:m:mtg2|MTG2]]|0.512|
|[[:human genes:m:mrpl43|MRPL43]]|0.512|
|[[:human genes:m:mrpl22|MRPL22]]|0.511|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.51|
|[[:human genes:n:ndufb3|NDUFB3]]|0.509|
|[[:human genes:t:tmem126b|TMEM126B]]|0.508|
|[[:human genes:m:mars2|MARS2]]|0.507|
|[[:human genes:p:polrmt|POLRMT]]|0.507|
|[[:human genes:m:mtif2|MTIF2]]|0.505|
|[[:human genes:m:mrps26|MRPS26]]|0.505|
|[[:human genes:t:tomm20|TOMM20]]|0.505|
|[[:human genes:c:clpp|CLPP]]|0.503|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.503|
|[[:human genes:m:mrps9|MRPS9]]|0.503|
|[[:human genes:n:ndufa13|NDUFA13]]|0.503|
|[[:human genes:w:wars2|WARS2]]|0.502|
|[[:human genes:m:mrps11|MRPS11]]|0.502|
|[[:human genes:n:ndufaf1|NDUFAF1]]|0.502|
|[[:human genes:n:ndufb7|NDUFB7]]|0.499|
|[[:human genes:p:pet112|PET112]]|0.496|
|[[:human genes:m:mrps33|MRPS33]]|0.496|
|[[:human genes:m:mcat|MCAT]]|0.496|
|[[:human genes:m:malsu1|MALSU1]]|0.495|
|[[:human genes:c:coa6|COA6]]|0.493|
|[[:human genes:n:noa1|NOA1]]|0.493|
|[[:human genes:c:coa3|COA3]]|0.492|
|[[:human genes:m:mterfd2|MTERFD2]]|0.492|
|[[:human genes:t:timm8b|TIMM8B]]|0.489|
|[[:human genes:c:c1qbp|C1QBP]]|0.486|
|[[:human genes:h:hmgxb3|HMGXB3]]|0.485|
|[[:human genes:m:mrps27|MRPS27]]|0.485|
|[[:human genes:m:mrpl20|MRPL20]]|0.484|
|[[:human genes:m:mrpl12|MRPL12]]|0.484|
|[[:human genes:m:mrps23|MRPS23]]|0.484|
|[[:human genes:c:coq3|COQ3]]|0.483|
|[[:human genes:m:mtif3|MTIF3]]|0.483|
|[[:human genes:s:slc25a26|SLC25A26]]|0.482|
|[[:human genes:g:gtpbp6|GTPBP6]]|0.479|
|[[:human genes:n:ndufb10|NDUFB10]]|0.479|
|[[:human genes:n:ndufs3|NDUFS3]]|0.476|
|[[:human genes:c:cox7b|COX7B]]|0.474|
|[[:human genes:p:pdss1|PDSS1]]|0.473|
|[[:human genes:p:ptcd3|PTCD3]]|0.473|
|[[:human genes:s:slc25a3|SLC25A3]]|0.472|
|[[:human genes:m:mrpl3|MRPL3]]|0.471|
|[[:human genes:m:mrpl11|MRPL11]]|0.469|
|[[:human genes:u:uqcrc2|UQCRC2]]|0.467|
|[[:human genes:h:hars2|HARS2]]|0.466|
|[[:human genes:n:ndufv2|NDUFV2]]|0.465|
|[[:human genes:g:glrx5|GLRX5]]|0.465|
|[[:human genes:d:ddx28|DDX28]]|0.464|
|[[:human genes:m:mipep|MIPEP]]|0.464|
|[[:human genes:s:ssbp1|SSBP1]]|0.464|
|[[:human genes:g:gtpbp8|GTPBP8]]|0.463|
|[[:human genes:f:fars2|FARS2]]|0.461|
|[[:human genes:c:cox11|COX11]]|0.46|
|[[:human genes:a:aars2|AARS2]]|0.46|
|[[:human genes:m:mrpl13|MRPL13]]|0.459|
|[[:human genes:m:mrps10|MRPS10]]|0.456|
|[[:human genes:a:alas1|ALAS1]]|0.455|
|[[:human genes:c:cox20|COX20]]|0.455|
|[[:human genes:d:dhx30|DHX30]]|0.454|
|[[:human genes:r:rmnd1|RMND1]]|0.451|
|[[:human genes:m:mtrf1|MTRF1]]|0.446|
|[[:human genes:r:rnmtl1|RNMTL1]]|0.445|
|[[:human genes:e:eral1|ERAL1]]|0.445|
|[[:human genes:f:fastkd1|FASTKD1]]|0.444|
|[[:human genes:s:slc25a52|SLC25A52]]|0.441|
|[[:human genes:m:mrps22|MRPS22]]|0.439|
|[[:human genes:n:ndufb4|NDUFB4]]|0.439|
|[[:human genes:m:mrps12|MRPS12]]|0.439|
|[[:human genes:m:mrpl1|MRPL1]]|0.438|
|[[:human genes:m:mrps17|MRPS17]]|0.437|
|[[:human genes:t:trub2|TRUB2]]|0.436|
|[[:human genes:a:atp5c1|ATP5C1]]|0.434|
|[[:human genes:c:cox17|COX17]]|0.433|
|[[:human genes:m:mrpl38|MRPL38]]|0.433|
|[[:human genes:n:ndufa9|NDUFA9]]|0.431|
|[[:human genes:a:atp5d|ATP5D]]|0.43|
|[[:human genes:m:mrpl41|MRPL41]]|0.428|
|[[:human genes:m:mrps18b|MRPS18B]]|0.427|
|[[:human genes:m:mrpl28|MRPL28]]|0.427|
|[[:human genes:a:atp5a1|ATP5A1]]|0.424|
|[[:human genes:m:mrps28|MRPS28]]|0.423|
|[[:human genes:m:mrpl55|MRPL55]]|0.422|
|[[:human genes:m:mtpap|MTPAP]]|0.421|
|[[:human genes:s:sfxn4|SFXN4]]|0.419|
|[[:human genes:c:coq6|COQ6]]|0.419|
|[[:human genes:t:tmem242|TMEM242]]|0.418|
|[[:human genes:s:slc25a51|SLC25A51]]|0.418|
|[[:human genes:l:lrpprc|LRPPRC]]|0.418|
|[[:human genes:e:elac2|ELAC2]]|0.417|
|[[:human genes:m:mrpl33|MRPL33]]|0.417|
|[[:human genes:h:higd2a|HIGD2A]]|0.416|
|[[:human genes:n:ndufb1|NDUFB1]]|0.415|
|[[:human genes:p:pitrm1|PITRM1]]|0.415|
|[[:human genes:c:cox5a|COX5A]]|0.413|
|[[:human genes:m:mrpl46|MRPL46]]|0.412|
|[[:human genes:a:aldh18a1|ALDH18A1]]|0.412|
|[[:human genes:d:dhrsx|DHRSX]]|0.411|
|[[:human genes:m:mrpl35|MRPL35]]|0.41|
|[[:human genes:t:tomm7|TOMM7]]|0.41|
|[[:human genes:n:ndufb8|NDUFB8]]|0.407|
|[[:human genes:m:mrpl51|MRPL51]]|0.405|
|[[:human genes:t:timm21|TIMM21]]|0.404|
|[[:human genes:m:mrpl42|MRPL42]]|0.404|
|[[:human genes:a:ak3|AK3]]|0.402|
|[[:human genes:m:minos1|MINOS1]]|0.401|
|[[:human genes:a:alkbh1|ALKBH1]]|0.401|
|[[:human genes:c:coq4|COQ4]]|0.4|
|[[:human genes:t:tfam|TFAM]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 17/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|1/26|
|breast|1/33|
|central nervous system|1/56|
|cervix|1/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|1/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1827
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.55 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NDUFAF7 Expression in NALM6 Cells: 5.55'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>