======= NDUFB2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NDUFB2
  * **<color #00a2e8>Official Name</color>**: N/ADH:ubiquinone oxidoreductase subunit B2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4708|4708]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O95178|O95178]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NDUFB2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NDUFB2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603838|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. {ECO:0000269|PubMed:27626371}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|NADH dehydrogenase (ubiquinone) activity|
|mitochondrial electron transport, NADH to ubiquinone|
|mitochondrial respiratory chain complex I|
|NADH dehydrogenase complex assembly|
|mitochondrial respiratory chain complex I assembly|
|mitochondrial ATP synthesis coupled electron transport|
|ATP synthesis coupled electron transport|
|mitochondrial respiratory chain complex assembly|
|respiratory electron transport chain|
|oxidative phosphorylation|
|cellular respiration|
|electron transport chain|
|ATP metabolic process|
|energy derivation by oxidation of organic compounds|
|mitochondrial inner membrane|
|generation of precursor metabolites and energy|
|mitochondrion organization|
|cellular protein-containing complex assembly|
|oxidation-reduction process|
|phosphorylation|
|protein-containing complex assembly|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|1.72|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|1.77|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|1.99|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|2|
|[[:results:exp360|Genistein 15μM R07 exp360]]|2.16|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|2.26|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|2.55|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:ndufa2|NDUFA2]]|0.598|
|[[:human genes:n:ndufb11|NDUFB11]]|0.576|
|[[:human genes:n:ndufa11|NDUFA11]]|0.571|
|[[:human genes:n:nubpl|NUBPL]]|0.566|
|[[:human genes:n:ndufs2|NDUFS2]]|0.553|
|[[:human genes:g:grsf1|GRSF1]]|0.552|
|[[:human genes:e:ecsit|ECSIT]]|0.547|
|[[:human genes:a:acad9|ACAD9]]|0.545|
|[[:human genes:n:ndufb9|NDUFB9]]|0.537|
|[[:human genes:n:ndufa1|NDUFA1]]|0.526|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.52|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.517|
|[[:human genes:n:ndufa8|NDUFA8]]|0.515|
|[[:human genes:n:ndufc2|NDUFC2]]|0.511|
|[[:human genes:n:ndufb6|NDUFB6]]|0.501|
|[[:human genes:n:ndufs8|NDUFS8]]|0.5|
|[[:human genes:m:mto1|MTO1]]|0.498|
|[[:human genes:n:ndufb10|NDUFB10]]|0.494|
|[[:human genes:n:ndufaf6|NDUFAF6]]|0.492|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.492|
|[[:human genes:n:ndufa3|NDUFA3]]|0.492|
|[[:human genes:n:ndufb5|NDUFB5]]|0.488|
|[[:human genes:n:ndufc1|NDUFC1]]|0.482|
|[[:human genes:n:ndufs5|NDUFS5]]|0.48|
|[[:human genes:p:pet117|PET117]]|0.479|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.478|
|[[:human genes:n:ndufa10|NDUFA10]]|0.476|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.475|
|[[:human genes:n:ndufa6|NDUFA6]]|0.471|
|[[:human genes:n:ndufv2|NDUFV2]]|0.471|
|[[:human genes:c:chchd1|CHCHD1]]|0.469|
|[[:human genes:n:ndufs3|NDUFS3]]|0.465|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.459|
|[[:human genes:n:ndufs7|NDUFS7]]|0.456|
|[[:human genes:c:coq2|COQ2]]|0.452|
|[[:human genes:n:ndufv1|NDUFV1]]|0.45|
|[[:human genes:f:fastkd2|FASTKD2]]|0.449|
|[[:human genes:h:hmgxb3|HMGXB3]]|0.444|
|[[:human genes:n:ndufb7|NDUFB7]]|0.44|
|[[:human genes:m:mtg1|MTG1]]|0.438|
|[[:human genes:m:mipep|MIPEP]]|0.431|
|[[:human genes:m:mettl17|METTL17]]|0.431|
|[[:human genes:f:foxred1|FOXRED1]]|0.43|
|[[:human genes:n:ndufb4|NDUFB4]]|0.43|
|[[:human genes:r:rbfa|RBFA]]|0.428|
|[[:human genes:c:c17orf89|C17orf89]]|0.426|
|[[:human genes:n:ndufa13|NDUFA13]]|0.425|
|[[:human genes:n:nfu1|NFU1]]|0.425|
|[[:human genes:g:glrx5|GLRX5]]|0.424|
|[[:human genes:p:pet112|PET112]]|0.422|
|[[:human genes:n:ndufb3|NDUFB3]]|0.421|
|[[:human genes:i:iba57|IBA57]]|0.421|
|[[:human genes:m:mrps21|MRPS21]]|0.419|
|[[:human genes:m:mrpl55|MRPL55]]|0.419|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.418|
|[[:human genes:a:atp5sl|ATP5SL]]|0.417|
|[[:human genes:m:mrpl15|MRPL15]]|0.413|
|[[:human genes:m:mcat|MCAT]]|0.411|
|[[:human genes:c:c12orf65|C12orf65]]|0.411|
|[[:human genes:p:polg2|POLG2]]|0.41|
|[[:human genes:f:ftsj2|FTSJ2]]|0.41|
|[[:human genes:m:mrpl1|MRPL1]]|0.41|
|[[:human genes:p:ptcd1|PTCD1]]|0.408|
|[[:human genes:m:mrpl21|MRPL21]]|0.403|
|[[:human genes:c:coq7|COQ7]]|0.403|
|[[:human genes:n:noa1|NOA1]]|0.402|
|[[:human genes:m:mrpl45|MRPL45]]|0.402|
|[[:human genes:n:ndufaf5|NDUFAF5]]|0.402|
|[[:human genes:s:selrc1|SELRC1]]|0.402|
|[[:human genes:n:ndufaf1|NDUFAF1]]|0.401|
|[[:human genes:m:mterfd1|MTERFD1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 3/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1903
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.45 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NDUFB2 Expression in NALM6 Cells: 5.45'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>