======= NDUFS2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NDUFS2
  * **<color #00a2e8>Official Name</color>**: N/ADH:ubiquinone oxidoreductase core subunit S2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4720|4720]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75306|O75306]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NDUFS2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NDUFS2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602985|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (complex I). Mammalian mitochondrial complex I is composed of at least 43 different subunits, 7 of which are encoded by the mitochondrial genome, and the rest are the products of nuclear genes. The iron-sulfur protein fraction of complex I is made up of 7 subunits, including this gene product. Complex I catalyzes the NADH oxidation with concomitant ubiquinone reduction and proton ejection out of the mitochondria. Mutations in this gene are associated with mitochondrial complex I deficiency. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (PubMed:12611891). {ECO:0000269|PubMed:12611891}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Complex1 49kDa|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|quinone binding|
|NADH dehydrogenase activity|
|NAD binding|
|4 iron, 4 sulfur cluster binding|
|NADH dehydrogenase (ubiquinone) activity|
|mitochondrial electron transport, NADH to ubiquinone|
|mitochondrial respiratory chain complex I|
|mitochondrial respiratory chain complex I assembly|
|NADH dehydrogenase complex assembly|
|electron transfer activity|
|mitochondrial ATP synthesis coupled electron transport|
|ATP synthesis coupled electron transport|
|mitochondrial respiratory chain complex assembly|
|respiratory electron transport chain|
|oxidative phosphorylation|
|cellular respiration|
|electron transport chain|
|ATP metabolic process|
|energy derivation by oxidation of organic compounds|
|ubiquitin protein ligase binding|
|mitochondrial matrix|
|response to oxidative stress|
|generation of precursor metabolites and energy|
|mitochondrion organization|
|cellular protein-containing complex assembly|
|oxidation-reduction process|
|mitochondrion|
|phosphorylation|
|protein-containing complex assembly|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|-1.78|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|1.71|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|1.73|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|1.76|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|1.87|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|1.88|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|1.88|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|1.89|
|[[:results:exp360|Genistein 15μM R07 exp360]]|1.96|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|1.98|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|1.99|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|2|
|[[:results:exp534|Trientine 500μM R08 exp534]]|2.04|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|2.35|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|2.45|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|2.5|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|2.52|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|3.21|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|3.63|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:ndufb11|NDUFB11]]|0.733|
|[[:human genes:a:acad9|ACAD9]]|0.711|
|[[:human genes:n:ndufa2|NDUFA2]]|0.71|
|[[:human genes:n:ndufa1|NDUFA1]]|0.708|
|[[:human genes:n:nubpl|NUBPL]]|0.704|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.689|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.687|
|[[:human genes:n:ndufa3|NDUFA3]]|0.684|
|[[:human genes:n:ndufa11|NDUFA11]]|0.677|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.668|
|[[:human genes:n:ndufs5|NDUFS5]]|0.663|
|[[:human genes:n:ndufb9|NDUFB9]]|0.663|
|[[:human genes:m:mto1|MTO1]]|0.65|
|[[:human genes:n:ndufc2|NDUFC2]]|0.648|
|[[:human genes:n:ndufv1|NDUFV1]]|0.643|
|[[:human genes:n:ndufb7|NDUFB7]]|0.636|
|[[:human genes:n:ndufaf6|NDUFAF6]]|0.634|
|[[:human genes:g:grsf1|GRSF1]]|0.631|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.631|
|[[:human genes:n:ndufa8|NDUFA8]]|0.628|
|[[:human genes:e:ecsit|ECSIT]]|0.625|
|[[:human genes:n:ndufs7|NDUFS7]]|0.616|
|[[:human genes:n:ndufc1|NDUFC1]]|0.604|
|[[:human genes:f:ftsj2|FTSJ2]]|0.601|
|[[:human genes:n:ndufb6|NDUFB6]]|0.597|
|[[:human genes:r:rpusd3|RPUSD3]]|0.586|
|[[:human genes:n:ndufa10|NDUFA10]]|0.586|
|[[:human genes:n:ndufa6|NDUFA6]]|0.584|
|[[:human genes:n:ndufb4|NDUFB4]]|0.584|
|[[:human genes:p:polg2|POLG2]]|0.581|
|[[:human genes:n:ndufaf5|NDUFAF5]]|0.576|
|[[:human genes:l:lars2|LARS2]]|0.57|
|[[:human genes:c:chchd1|CHCHD1]]|0.567|
|[[:human genes:p:pet117|PET117]]|0.567|
|[[:human genes:n:ndufs8|NDUFS8]]|0.559|
|[[:human genes:q:qrsl1|QRSL1]]|0.555|
|[[:human genes:n:ndufv2|NDUFV2]]|0.554|
|[[:human genes:n:ndufb5|NDUFB5]]|0.553|
|[[:human genes:n:ndufb2|NDUFB2]]|0.553|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.553|
|[[:human genes:f:fastkd2|FASTKD2]]|0.55|
|[[:human genes:c:cars2|CARS2]]|0.55|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.548|
|[[:human genes:n:ndufs3|NDUFS3]]|0.546|
|[[:human genes:n:ndufb10|NDUFB10]]|0.543|
|[[:human genes:g:gfm1|GFM1]]|0.543|
|[[:human genes:n:nars2|NARS2]]|0.543|
|[[:human genes:n:ndufa13|NDUFA13]]|0.538|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.537|
|[[:human genes:m:mrps25|MRPS25]]|0.535|
|[[:human genes:a:aars2|AARS2]]|0.532|
|[[:human genes:m:mrp63|MRP63]]|0.529|
|[[:human genes:g:gfm2|GFM2]]|0.526|
|[[:human genes:c:coq7|COQ7]]|0.524|
|[[:human genes:m:mrps21|MRPS21]]|0.524|
|[[:human genes:c:c12orf65|C12orf65]]|0.522|
|[[:human genes:p:pet112|PET112]]|0.521|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.521|
|[[:human genes:n:ndufs1|NDUFS1]]|0.52|
|[[:human genes:m:mrpl45|MRPL45]]|0.52|
|[[:human genes:h:hmgxb3|HMGXB3]]|0.519|
|[[:human genes:t:tfb1m|TFB1M]]|0.519|
|[[:human genes:m:mettl17|METTL17]]|0.519|
|[[:human genes:m:mrpl21|MRPL21]]|0.517|
|[[:human genes:c:c10orf2|C10orf2]]|0.515|
|[[:human genes:c:c17orf89|C17orf89]]|0.515|
|[[:human genes:n:ndufa5|NDUFA5]]|0.514|
|[[:human genes:t:tmem261|TMEM261]]|0.512|
|[[:human genes:m:mterfd1|MTERFD1]]|0.51|
|[[:human genes:m:mrps26|MRPS26]]|0.508|
|[[:human genes:s:selrc1|SELRC1]]|0.508|
|[[:human genes:d:dap3|DAP3]]|0.508|
|[[:human genes:s:ssbp1|SSBP1]]|0.506|
|[[:human genes:m:mrpl43|MRPL43]]|0.505|
|[[:human genes:f:foxred1|FOXRED1]]|0.505|
|[[:human genes:g:gtpbp6|GTPBP6]]|0.503|
|[[:human genes:m:malsu1|MALSU1]]|0.501|
|[[:human genes:m:mrps18b|MRPS18B]]|0.495|
|[[:human genes:t:tefm|TEFM]]|0.495|
|[[:human genes:n:nfu1|NFU1]]|0.494|
|[[:human genes:s:sco2|SCO2]]|0.494|
|[[:human genes:m:mrpl44|MRPL44]]|0.492|
|[[:human genes:w:wbscr16|WBSCR16]]|0.491|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.49|
|[[:human genes:m:mtg1|MTG1]]|0.488|
|[[:human genes:g:glrx5|GLRX5]]|0.488|
|[[:human genes:i:iba57|IBA57]]|0.488|
|[[:human genes:y:yars2|YARS2]]|0.487|
|[[:human genes:a:atp5sl|ATP5SL]]|0.485|
|[[:human genes:m:mrps27|MRPS27]]|0.484|
|[[:human genes:t:tars2|TARS2]]|0.483|
|[[:human genes:n:ndufb3|NDUFB3]]|0.482|
|[[:human genes:n:ndufaf1|NDUFAF1]]|0.482|
|[[:human genes:e:ears2|EARS2]]|0.481|
|[[:human genes:c:coq2|COQ2]]|0.48|
|[[:human genes:m:mrps9|MRPS9]]|0.479|
|[[:human genes:m:mtif2|MTIF2]]|0.479|
|[[:human genes:m:mrpl15|MRPL15]]|0.479|
|[[:human genes:m:mipep|MIPEP]]|0.474|
|[[:human genes:e:eral1|ERAL1]]|0.474|
|[[:human genes:p:polg|POLG]]|0.474|
|[[:human genes:d:ddx28|DDX28]]|0.472|
|[[:human genes:p:polrmt|POLRMT]]|0.472|
|[[:human genes:m:mrps6|MRPS6]]|0.471|
|[[:human genes:m:mrpl47|MRPL47]]|0.471|
|[[:human genes:s:slc25a51|SLC25A51]]|0.47|
|[[:human genes:n:noa1|NOA1]]|0.469|
|[[:human genes:n:ndufa9|NDUFA9]]|0.468|
|[[:human genes:m:mrpl13|MRPL13]]|0.468|
|[[:human genes:r:rbfa|RBFA]]|0.468|
|[[:human genes:m:mrps34|MRPS34]]|0.468|
|[[:human genes:p:ptcd3|PTCD3]]|0.467|
|[[:human genes:c:clpp|CLPP]]|0.466|
|[[:human genes:p:pars2|PARS2]]|0.466|
|[[:human genes:r:rmnd1|RMND1]]|0.465|
|[[:human genes:p:pnpt1|PNPT1]]|0.464|
|[[:human genes:m:mrps16|MRPS16]]|0.462|
|[[:human genes:a:aifm1|AIFM1]]|0.462|
|[[:human genes:m:mrps10|MRPS10]]|0.461|
|[[:human genes:m:mrps5|MRPS5]]|0.461|
|[[:human genes:r:rars2|RARS2]]|0.461|
|[[:human genes:w:wars2|WARS2]]|0.46|
|[[:human genes:f:fars2|FARS2]]|0.459|
|[[:human genes:m:mrps12|MRPS12]]|0.459|
|[[:human genes:b:bcs1l|BCS1L]]|0.458|
|[[:human genes:n:ndufb8|NDUFB8]]|0.458|
|[[:human genes:p:prepl|PREPL]]|0.456|
|[[:human genes:m:mrpl3|MRPL3]]|0.455|
|[[:human genes:d:dars2|DARS2]]|0.455|
|[[:human genes:x:xpnpep3|XPNPEP3]]|0.454|
|[[:human genes:s:slc25a3|SLC25A3]]|0.453|
|[[:human genes:i:ict1|ICT1]]|0.451|
|[[:human genes:t:tomm20|TOMM20]]|0.451|
|[[:human genes:p:pde12|PDE12]]|0.451|
|[[:human genes:v:vars2|VARS2]]|0.45|
|[[:human genes:c:coa3|COA3]]|0.45|
|[[:human genes:t:tufm|TUFM]]|0.45|
|[[:human genes:m:mrpl53|MRPL53]]|0.45|
|[[:human genes:t:tomm6|TOMM6]]|0.449|
|[[:human genes:c:c1qbp|C1QBP]]|0.448|
|[[:human genes:m:mtg2|MTG2]]|0.447|
|[[:human genes:s:sfxn4|SFXN4]]|0.445|
|[[:human genes:m:mcat|MCAT]]|0.443|
|[[:human genes:r:rpusd4|RPUSD4]]|0.442|
|[[:human genes:g:gtpbp8|GTPBP8]]|0.442|
|[[:human genes:m:mrps22|MRPS22]]|0.441|
|[[:human genes:m:mrpl49|MRPL49]]|0.441|
|[[:human genes:c:coa6|COA6]]|0.44|
|[[:human genes:m:mrps24|MRPS24]]|0.44|
|[[:human genes:m:mrps33|MRPS33]]|0.438|
|[[:human genes:m:mrpl12|MRPL12]]|0.436|
|[[:human genes:f:fastkd5|FASTKD5]]|0.435|
|[[:human genes:t:tfam|TFAM]]|0.434|
|[[:human genes:m:mrps14|MRPS14]]|0.432|
|[[:human genes:m:mrpl20|MRPL20]]|0.429|
|[[:human genes:m:mrpl2|MRPL2]]|0.425|
|[[:human genes:t:trub2|TRUB2]]|0.422|
|[[:human genes:m:mars2|MARS2]]|0.42|
|[[:human genes:g:gatc|GATC]]|0.42|
|[[:human genes:m:mrpl35|MRPL35]]|0.418|
|[[:human genes:m:mrpl38|MRPL38]]|0.417|
|[[:human genes:l:lrpprc|LRPPRC]]|0.417|
|[[:human genes:c:cox15|COX15]]|0.417|
|[[:human genes:r:rnmtl1|RNMTL1]]|0.416|
|[[:human genes:s:slc25a52|SLC25A52]]|0.415|
|[[:human genes:n:nsun4|NSUN4]]|0.415|
|[[:human genes:m:mrpl23|MRPL23]]|0.412|
|[[:human genes:c:cluh|CLUH]]|0.41|
|[[:human genes:c:cox11|COX11]]|0.409|
|[[:human genes:t:trit1|TRIT1]]|0.409|
|[[:human genes:m:mrps17|MRPS17]]|0.408|
|[[:human genes:a:atp5c1|ATP5C1]]|0.408|
|[[:human genes:h:hars2|HARS2]]|0.407|
|[[:human genes:m:mrps11|MRPS11]]|0.406|
|[[:human genes:m:mterfd2|MTERFD2]]|0.406|
|[[:human genes:m:mrpl22|MRPL22]]|0.404|
|[[:human genes:c:cox16|COX16]]|0.404|
|[[:human genes:c:coq4|COQ4]]|0.403|
|[[:human genes:m:mtrf1|MTRF1]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 21/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|1/28|
|bone|1/26|
|breast|2/33|
|central nervous system|1/56|
|cervix|1/4|
|colorectal|2/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|2/16|
|kidney|2/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|1/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|2/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 668
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.01 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NDUFS2 Expression in NALM6 Cells: 6.01'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>