======= NDUFS3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NDUFS3
  * **<color #00a2e8>Official Name</color>**: N/ADH:ubiquinone oxidoreductase core subunit S3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4722|4722]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75489|O75489]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NDUFS3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NDUFS3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603846|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes one of the iron-sulfur protein (IP) components of mitochondrial NADH:ubiquinone oxidoreductase (complex I). Mutations in this gene are associated with Leigh syndrome resulting from mitochondrial complex I deficiency.[provided by RefSeq, Apr 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Complex1 30kDa|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|NADH dehydrogenase activity|
|substantia nigra development|
|NADH dehydrogenase (ubiquinone) activity|
|mitochondrial electron transport, NADH to ubiquinone|
|mitochondrial respiratory chain complex I|
|neural nucleus development|
|NADH dehydrogenase complex assembly|
|mitochondrial respiratory chain complex I assembly|
|electron transfer activity|
|midbrain development|
|mitochondrial ATP synthesis coupled electron transport|
|ATP synthesis coupled electron transport|
|negative regulation of intrinsic apoptotic signaling pathway|
|mitochondrial respiratory chain complex assembly|
|mitochondrial membrane|
|respiratory electron transport chain|
|reactive oxygen species metabolic process|
|oxidative phosphorylation|
|regulation of intrinsic apoptotic signaling pathway|
|cellular respiration|
|electron transport chain|
|negative regulation of cell growth|
|ATP metabolic process|
|negative regulation of apoptotic signaling pathway|
|energy derivation by oxidation of organic compounds|
|negative regulation of growth|
|nuclear body|
|mitochondrial matrix|
|regulation of apoptotic signaling pathway|
|regulation of cell growth|
|generation of precursor metabolites and energy|
|mitochondrion organization|
|negative regulation of intracellular signal transduction|
|regulation of growth|
|brain development|
|head development|
|cellular protein-containing complex assembly|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|oxidation-reduction process|
|central nervous system development|
|negative regulation of cell death|
|mitochondrion|
|negative regulation of signal transduction|
|phosphorylation|
|negative regulation of cell communication|
|negative regulation of signaling|
|regulation of apoptotic process|
|protein-containing complex assembly|
|regulation of programmed cell death|
|negative regulation of response to stimulus|
|regulation of cell death|
|regulation of intracellular signal transduction|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|-1.77|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|1.75|
|[[:results:exp360|Genistein 15μM R07 exp360]]|2.13|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|2.14|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|2.36|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|2.8|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|2.99|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:ndufa1|NDUFA1]]|0.565|
|[[:human genes:g:grsf1|GRSF1]]|0.557|
|[[:human genes:n:ndufc1|NDUFC1]]|0.555|
|[[:human genes:n:ndufb11|NDUFB11]]|0.553|
|[[:human genes:n:ndufs2|NDUFS2]]|0.546|
|[[:human genes:n:ndufc2|NDUFC2]]|0.539|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.534|
|[[:human genes:n:ndufa2|NDUFA2]]|0.53|
|[[:human genes:n:ndufa11|NDUFA11]]|0.518|
|[[:human genes:n:ndufaf6|NDUFAF6]]|0.518|
|[[:human genes:n:ndufb9|NDUFB9]]|0.514|
|[[:human genes:n:ndufa10|NDUFA10]]|0.506|
|[[:human genes:a:acad9|ACAD9]]|0.506|
|[[:human genes:e:ecsit|ECSIT]]|0.502|
|[[:human genes:n:ndufb7|NDUFB7]]|0.495|
|[[:human genes:n:ndufb4|NDUFB4]]|0.49|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.487|
|[[:human genes:n:nubpl|NUBPL]]|0.484|
|[[:human genes:n:ndufa3|NDUFA3]]|0.484|
|[[:human genes:n:ndufs1|NDUFS1]]|0.483|
|[[:human genes:n:ndufaf5|NDUFAF5]]|0.48|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.476|
|[[:human genes:n:ndufb2|NDUFB2]]|0.465|
|[[:human genes:n:ndufb6|NDUFB6]]|0.462|
|[[:human genes:n:ndufb10|NDUFB10]]|0.461|
|[[:human genes:n:ndufs5|NDUFS5]]|0.456|
|[[:human genes:n:ndufs8|NDUFS8]]|0.453|
|[[:human genes:m:mto1|MTO1]]|0.453|
|[[:human genes:n:ndufa13|NDUFA13]]|0.451|
|[[:human genes:n:ndufb8|NDUFB8]]|0.45|
|[[:human genes:n:ndufaf1|NDUFAF1]]|0.447|
|[[:human genes:n:ndufs7|NDUFS7]]|0.446|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.443|
|[[:human genes:f:fastkd2|FASTKD2]]|0.443|
|[[:human genes:r:rpusd3|RPUSD3]]|0.442|
|[[:human genes:a:atp5sl|ATP5SL]]|0.442|
|[[:human genes:n:ndufv1|NDUFV1]]|0.44|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.434|
|[[:human genes:m:mrpl45|MRPL45]]|0.433|
|[[:human genes:n:ndufa8|NDUFA8]]|0.433|
|[[:human genes:l:lars2|LARS2]]|0.431|
|[[:human genes:t:tfb1m|TFB1M]]|0.431|
|[[:human genes:n:ndufb5|NDUFB5]]|0.422|
|[[:human genes:n:ndufa6|NDUFA6]]|0.414|
|[[:human genes:n:ndufv2|NDUFV2]]|0.405|
|[[:human genes:m:mterfd1|MTERFD1]]|0.404|
|[[:human genes:p:ptcd3|PTCD3]]|0.402|
|[[:human genes:m:mrps21|MRPS21]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1825
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.26 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NDUFS3 Expression in NALM6 Cells: 6.26'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>