======= NDUFS8 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NDUFS8
  * **<color #00a2e8>Official Name</color>**: N/ADH:ubiquinone oxidoreductase core subunit S8
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4728|4728]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O00217|O00217]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NDUFS8&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NDUFS8|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602141|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a subunit of mitochondrial NADH:ubiquinone oxidoreductase, or Complex I, a multimeric enzyme of the respiratory chain responsible for NADH oxidation, ubiquinone reduction, and the ejection of protons from mitochondria. The encoded protein is involved in the binding of two of the six to eight iron-sulfur clusters of Complex I and, as such, is required in the electron transfer process. Mutations in this gene have been associated with Leigh syndrome. [provided by RefSeq, Mar 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). May donate electrons to ubiquinone. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Fer4 7|
|Fer4|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|NADH dehydrogenase activity|
|4 iron, 4 sulfur cluster binding|
|NADH dehydrogenase (ubiquinone) activity|
|mitochondrial electron transport, NADH to ubiquinone|
|mitochondrial respiratory chain complex I|
|mitochondrial respiratory chain complex I assembly|
|NADH dehydrogenase complex assembly|
|aerobic respiration|
|mitochondrial ATP synthesis coupled electron transport|
|ATP synthesis coupled electron transport|
|mitochondrial respiratory chain complex assembly|
|respiratory electron transport chain|
|oxidative phosphorylation|
|cellular respiration|
|electron transport chain|
|ATP metabolic process|
|energy derivation by oxidation of organic compounds|
|mitochondrial matrix|
|response to oxidative stress|
|generation of precursor metabolites and energy|
|mitochondrion organization|
|cellular protein-containing complex assembly|
|oxidation-reduction process|
|mitochondrion|
|phosphorylation|
|protein-containing complex assembly|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|1.71|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|1.74|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|1.9|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|1.95|
|[[:results:exp465|Cannabidiol 13μM R08 exp465]]|2.11|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|2.3|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|2.47|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|2.57|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:g:grsf1|GRSF1]]|0.631|
|[[:human genes:n:ndufaf6|NDUFAF6]]|0.617|
|[[:human genes:m:mto1|MTO1]]|0.614|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.609|
|[[:human genes:a:acad9|ACAD9]]|0.599|
|[[:human genes:n:ndufb9|NDUFB9]]|0.593|
|[[:human genes:n:nubpl|NUBPL]]|0.593|
|[[:human genes:n:ndufa2|NDUFA2]]|0.576|
|[[:human genes:n:ndufb7|NDUFB7]]|0.573|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.569|
|[[:human genes:n:ndufb11|NDUFB11]]|0.561|
|[[:human genes:e:ecsit|ECSIT]]|0.56|
|[[:human genes:n:ndufs2|NDUFS2]]|0.559|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.549|
|[[:human genes:n:ndufa3|NDUFA3]]|0.547|
|[[:human genes:n:ndufs7|NDUFS7]]|0.545|
|[[:human genes:n:ndufa1|NDUFA1]]|0.533|
|[[:human genes:n:ndufs5|NDUFS5]]|0.527|
|[[:human genes:n:ndufa11|NDUFA11]]|0.525|
|[[:human genes:n:ndufc1|NDUFC1]]|0.522|
|[[:human genes:n:ndufa8|NDUFA8]]|0.511|
|[[:human genes:n:ndufv2|NDUFV2]]|0.51|
|[[:human genes:n:ndufb6|NDUFB6]]|0.509|
|[[:human genes:n:ndufaf5|NDUFAF5]]|0.508|
|[[:human genes:n:ndufa6|NDUFA6]]|0.508|
|[[:human genes:n:ndufb10|NDUFB10]]|0.506|
|[[:human genes:n:ndufv1|NDUFV1]]|0.506|
|[[:human genes:m:mtif2|MTIF2]]|0.504|
|[[:human genes:n:ndufc2|NDUFC2]]|0.504|
|[[:human genes:n:ndufb5|NDUFB5]]|0.503|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.501|
|[[:human genes:n:ndufa13|NDUFA13]]|0.501|
|[[:human genes:n:ndufb2|NDUFB2]]|0.5|
|[[:human genes:n:ndufs1|NDUFS1]]|0.498|
|[[:human genes:c:c17orf89|C17orf89]]|0.493|
|[[:human genes:n:ndufaf1|NDUFAF1]]|0.488|
|[[:human genes:c:chchd1|CHCHD1]]|0.481|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.469|
|[[:human genes:p:polg2|POLG2]]|0.469|
|[[:human genes:f:foxred1|FOXRED1]]|0.469|
|[[:human genes:c:c1qbp|C1QBP]]|0.468|
|[[:human genes:p:prim1|PRIM1]]|0.464|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.457|
|[[:human genes:f:fastkd2|FASTKD2]]|0.457|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.456|
|[[:human genes:n:ndufs3|NDUFS3]]|0.453|
|[[:human genes:p:pet117|PET117]]|0.451|
|[[:human genes:n:ndufb4|NDUFB4]]|0.449|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.449|
|[[:human genes:t:tars2|TARS2]]|0.446|
|[[:human genes:n:ndufa9|NDUFA9]]|0.445|
|[[:human genes:r:rmnd1|RMND1]]|0.439|
|[[:human genes:c:cars2|CARS2]]|0.438|
|[[:human genes:m:mrps27|MRPS27]]|0.438|
|[[:human genes:c:coq2|COQ2]]|0.437|
|[[:human genes:p:pet112|PET112]]|0.436|
|[[:human genes:n:ndufa10|NDUFA10]]|0.434|
|[[:human genes:m:mtg2|MTG2]]|0.431|
|[[:human genes:m:mettl17|METTL17]]|0.43|
|[[:human genes:w:wbscr16|WBSCR16]]|0.43|
|[[:human genes:g:gfm1|GFM1]]|0.427|
|[[:human genes:c:coq7|COQ7]]|0.427|
|[[:human genes:m:mrps25|MRPS25]]|0.425|
|[[:human genes:c:c12orf65|C12orf65]]|0.423|
|[[:human genes:t:tmem261|TMEM261]]|0.423|
|[[:human genes:t:trub2|TRUB2]]|0.42|
|[[:human genes:m:mrpl45|MRPL45]]|0.419|
|[[:human genes:q:qrsl1|QRSL1]]|0.418|
|[[:human genes:m:mterfd1|MTERFD1]]|0.416|
|[[:human genes:c:c10orf2|C10orf2]]|0.413|
|[[:human genes:i:iba57|IBA57]]|0.411|
|[[:human genes:s:slc25a3|SLC25A3]]|0.409|
|[[:human genes:m:malsu1|MALSU1]]|0.409|
|[[:human genes:m:mrps21|MRPS21]]|0.406|
|[[:human genes:r:rnmtl1|RNMTL1]]|0.405|
|[[:human genes:m:mtg1|MTG1]]|0.404|
|[[:human genes:g:gfm2|GFM2]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 40/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|0/28|
|bone|1/26|
|breast|4/33|
|central nervous system|2/56|
|cervix|1/4|
|colorectal|2/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|2/16|
|kidney|2/21|
|liver|3/20|
|lung|4/75|
|lymphocyte|1/16|
|ovary|1/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1018
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.62 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NDUFS8 Expression in NALM6 Cells: 5.62'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>