======= NEURL =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NEURL1
  * **<color #00a2e8>Official Name</color>**: neuralized E3 ubiquitin protein ligase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9148|9148]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O76050|O76050]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NEURL&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NEURL|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603804|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role in hippocampal-dependent synaptic plasticity, learning and memory. Involved in the formation of spines and functional synaptic contacts by modulating the translational activity of the cytoplasmic polyadenylation element- binding protein CPEB3. Promotes ubiquitination of CPEB3, and hence induces CPEB3-dependent mRNA translation activation of glutamate receptor GRIA1 and GRIA2. Can function as an E3 ubiquitin-protein ligase to activate monoubiquitination of JAG1 (in vitro), thereby regulating the Notch pathway. Acts as a tumor suppressor; inhibits malignant cell transformation of medulloblastoma (MB) cells by inhibiting the Notch signaling pathway. {ECO:0000269|PubMed:20847082}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Neuralized|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|translation factor activity, non-nucleic acid binding|
|positive regulation of long-term neuronal synaptic plasticity|
|positive regulation of synapse maturation|
|positive regulation of epidermal growth factor-activated receptor activity|
|sperm axoneme assembly|
|regulation of synapse maturation|
|apical dendrite|
|regulation of long-term neuronal synaptic plasticity|
|regulation of epidermal growth factor-activated receptor activity|
|positive regulation of filopodium assembly|
|positive regulation of epidermal growth factor receptor signaling pathway|
|positive regulation of ERBB signaling pathway|
|positive regulation of signaling receptor activity|
|negative regulation of Notch signaling pathway|
|positive regulation of dendritic spine development|
|lactation|
|regulation of filopodium assembly|
|regulation of neuronal synaptic plasticity|
|positive regulation of protein tyrosine kinase activity|
|protein monoubiquitination|
|axoneme assembly|
|cellular response to amino acid stimulus|
|flagellated sperm motility|
|sperm motility|
|regulation of dendritic spine development|
|positive regulation of dendrite development|
|body fluid secretion|
|regulation of epidermal growth factor receptor signaling pathway|
|regulation of protein tyrosine kinase activity|
|regulation of ERBB signaling pathway|
|microtubule bundle formation|
|cilium or flagellum-dependent cell motility|
|cilium-dependent cell motility|
|positive regulation of plasma membrane bounded cell projection assembly|
|regulation of Notch signaling pathway|
|response to amino acid|
|skeletal muscle tissue development|
|Notch signaling pathway|
|mammary gland development|
|skeletal muscle organ development|
|perikaryon|
|dendritic spine|
|regulation of dendrite development|
|spermatid development|
|spermatid differentiation|
|regulation of signaling receptor activity|
|regulation of synaptic plasticity|
|positive regulation of peptidyl-tyrosine phosphorylation|
|regulation of plasma membrane bounded cell projection assembly|
|postsynaptic membrane|
|regulation of cell projection assembly|
|cellular response to acid chemical|
|regulation of synapse organization|
|ubiquitin protein ligase activity|
|regulation of synapse structure or activity|
|ubiquitin-protein transferase activity|
|postsynaptic density|
|regulation of peptidyl-tyrosine phosphorylation|
|germ cell development|
|positive regulation of neuron projection development|
|striated muscle tissue development|
|muscle organ development|
|muscle tissue development|
|response to acid chemical|
|cilium assembly|
|regulation of translation|
|cellular process involved in reproduction in multicellular organism|
|cilium organization|
|positive regulation of neuron differentiation|
|positive regulation of cell projection organization|
|regulation of cellular amide metabolic process|
|gland development|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|plasma membrane bounded cell projection assembly|
|cell projection assembly|
|positive regulation of neurogenesis|
|muscle structure development|
|microtubule cytoskeleton organization|
|regulation of body fluid levels|
|regulation of neuron projection development|
|positive regulation of cellular component biogenesis|
|posttranscriptional regulation of gene expression|
|positive regulation of protein kinase activity|
|positive regulation of nervous system development|
|positive regulation of cell development|
|spermatogenesis|
|cell junction|
|male gamete generation|
|positive regulation of kinase activity|
|cellular response to organonitrogen compound|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|regulation of neuron differentiation|
|positive regulation of transferase activity|
|cellular response to nitrogen compound|
|developmental process involved in reproduction|
|microtubule-based process|
|negative regulation of cell population proliferation|
|protein ubiquitination|
|gamete generation|
|regulation of plasma membrane bounded cell projection organization|
|positive regulation of cell death|
|perinuclear region of cytoplasm|
|regulation of cell projection organization|
|brain development|
|organelle assembly|
|protein modification by small protein conjugation|
|head development|
|regulation of protein kinase activity|
|regulation of neurogenesis|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|regulation of kinase activity|
|regulation of nervous system development|
|regulation of cell development|
|regulation of cellular component biogenesis|
|positive regulation of cell differentiation|
|regulation of transferase activity|
|central nervous system development|
|protein modification by small protein conjugation or removal|
|multi-organism reproductive process|
|response to organonitrogen compound|
|positive regulation of protein phosphorylation|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|cell motility|
|localization of cell|
|response to nitrogen compound|
|cytoskeleton organization|
|secretion|
|plasma membrane bounded cell projection organization|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|cell projection organization|
|positive regulation of cellular component organization|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|locomotion|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|generation of neurons|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|neurogenesis|
|cell development|
|positive regulation of signal transduction|
|regulation of cell death|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|-1.85|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14496
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.16 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NEURL Expression in NALM6 Cells: -1.16'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>