======= NFE2L2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NFE2L2
  * **<color #00a2e8>Official Name</color>**: nuclear factor, erythroid 2 like 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4780|4780]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q16236|Q16236]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NFE2L2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NFE2L2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600492|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region. {ECO:0000269|PubMed:11035812}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|bZIP 1|
|bZIP 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of glutathione biosynthetic process|
|organic heteropentacyclic compound catabolic process|
|regulation of glutathione biosynthetic process|
|aflatoxin catabolic process|
|regulation of transcription from RNA polymerase II promoter in response to copper ion|
|mycotoxin catabolic process|
|organic heteropentacyclic compound metabolic process|
|negative regulation of hematopoietic stem cell differentiation|
|aflatoxin metabolic process|
|mycotoxin metabolic process|
|positive regulation of sulfur metabolic process|
|toxin catabolic process|
|positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress|
|negative regulation of vascular associated smooth muscle cell migration|
|positive regulation of transcription from RNA polymerase II promoter in response to hypoxia|
|transcription cofactor binding|
|cellular response to laminar fluid shear stress|
|positive regulation of ER-associated ubiquitin-dependent protein catabolic process|
|positive regulation of cofactor metabolic process|
|negative regulation of hematopoietic progenitor cell differentiation|
|regulation of ER-associated ubiquitin-dependent protein catabolic process|
|regulation of removal of superoxide radicals|
|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|
|PERK-mediated unfolded protein response|
|regulation of sulfur metabolic process|
|response to laminar fluid shear stress|
|positive regulation of ERAD pathway|
|negative regulation of hydrogen peroxide-induced cell death|
|negative regulation of response to reactive oxygen species|
|cellular response to fluid shear stress|
|negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway|
|negative regulation of cellular response to drug|
|negative regulation of stem cell differentiation|
|cellular response to angiotensin|
|negative regulation of smooth muscle cell migration|
|regulation of vascular associated smooth muscle cell migration|
|negative regulation of cardiac muscle cell apoptotic process|
|regulation of hydrogen peroxide-induced cell death|
|positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus|
|toxin metabolic process|
|proteasomal ubiquitin-independent protein catabolic process|
|negative regulation of striated muscle cell apoptotic process|
|response to angiotensin|
|positive regulation of hemostasis|
|positive regulation of blood coagulation|
|positive regulation of coagulation|
|regulation of oxidative stress-induced intrinsic apoptotic signaling pathway|
|negative regulation of response to drug|
|regulation of ERAD pathway|
|negative regulation of endothelial cell apoptotic process|
|cellular response to copper ion|
|positive regulation of transcription from RNA polymerase II promoter in response to stress|
|regulation of superoxide metabolic process|
|regulation of response to reactive oxygen species|
|response to fluid shear stress|
|regulation of cellular response to drug|
|ER-nucleus signaling pathway|
|regulation of cofactor metabolic process|
|positive regulation of glucose import|
|regulation of cardiac muscle cell apoptotic process|
|negative regulation of muscle cell apoptotic process|
|positive regulation of response to endoplasmic reticulum stress|
|regulation of striated muscle cell apoptotic process|
|cellular response to glucose starvation|
|negative regulation of epithelial cell apoptotic process|
|positive regulation of glucose transmembrane transport|
|protein-DNA complex|
|negative regulation of oxidative stress-induced cell death|
|response to copper ion|
|negative regulation of cellular response to oxidative stress|
|negative regulation of response to oxidative stress|
|regulation of endothelial cell apoptotic process|
|RNA polymerase II activating transcription factor binding|
|positive regulation of wound healing|
|positive regulation of blood vessel endothelial cell migration|
|secondary metabolic process|
|regulation of glucose import|
|regulation of smooth muscle cell migration|
|regulation of oxidative stress-induced cell death|
|positive regulation of response to wounding|
|regulation of muscle cell apoptotic process|
|cellular response to hydrogen peroxide|
|regulation of hematopoietic stem cell differentiation|
|regulation of glucose transmembrane transport|
|regulation of cellular response to oxidative stress|
|transcription regulatory region sequence-specific DNA binding|
|cell redox homeostasis|
|regulation of transcription from RNA polymerase II promoter in response to hypoxia|
|regulation of blood coagulation|
|regulation of epithelial cell apoptotic process|
|regulation of hemostasis|
|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|
|regulation of coagulation|
|regulation of response to endoplasmic reticulum stress|
|regulation of response to oxidative stress|
|regulation of hematopoietic progenitor cell differentiation|
|regulation of blood vessel endothelial cell migration|
|positive regulation of reactive oxygen species metabolic process|
|negative regulation of intrinsic apoptotic signaling pathway|
|positive regulation of ubiquitin-dependent protein catabolic process|
|regulation of response to drug|
|RNA polymerase II distal enhancer sequence-specific DNA binding|
|positive regulation of endothelial cell migration|
|positive regulation of proteasomal protein catabolic process|
|endoplasmic reticulum unfolded protein response|
|chromatin|
|regulation of stem cell differentiation|
|cellular response to antibiotic|
|response to hydrogen peroxide|
|regulation of transcription from RNA polymerase II promoter in response to stress|
|positive regulation of proteolysis involved in cellular protein catabolic process|
|regulation of proteasomal ubiquitin-dependent protein catabolic process|
|regulation of DNA-templated transcription in response to stress|
|cellular response to unfolded protein|
|detoxification|
|regulation of embryonic development|
|cellular response to reactive oxygen species|
|negative regulation of hemopoiesis|
|regulation of wound healing|
|positive regulation of cellular protein catabolic process|
|positive regulation of epithelial cell migration|
|cellular response to topologically incorrect protein|
|positive regulation of cellular amide metabolic process|
|cellular response to starvation|
|regulation of ubiquitin-dependent protein catabolic process|
|regulation of endothelial cell migration|
|regulation of intrinsic apoptotic signaling pathway|
|response to unfolded protein|
|positive regulation of angiogenesis|
|regulation of response to wounding|
|regulation of reactive oxygen species metabolic process|
|positive regulation of vasculature development|
|regulation of proteasomal protein catabolic process|
|response to topologically incorrect protein|
|cellular response to hypoxia|
|cellular response to metal ion|
|response to starvation|
|response to reactive oxygen species|
|cellular response to decreased oxygen levels|
|positive regulation of transmembrane transport|
|cellular response to toxic substance|
|cellular response to oxygen levels|
|positive regulation of protein catabolic process|
|regulation of proteolysis involved in cellular protein catabolic process|
|transcription regulatory region DNA binding|
|regulation of epithelial cell migration|
|cellular response to inorganic substance|
|negative regulation of apoptotic signaling pathway|
|cellular response to nutrient levels|
|cellular response to oxidative stress|
|cellular response to tumor necrosis factor|
|protein domain specific binding|
|regulation of cellular protein catabolic process|
|response to endoplasmic reticulum stress|
|negative regulation of cell migration|
|response to tumor necrosis factor|
|cellular response to extracellular stimulus|
|cellular response to peptide hormone stimulus|
|negative regulation of cell motility|
|aging|
|positive regulation of neuron projection development|
|regulation of angiogenesis|
|response to antibiotic|
|negative regulation of cellular component movement|
|regulation of vasculature development|
|negative regulation of locomotion|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|cellular response to peptide|
|cellular response to external stimulus|
|response to hypoxia|
|proteasomal protein catabolic process|
|response to decreased oxygen levels|
|positive regulation of proteolysis|
|positive regulation of cellular catabolic process|
|positive regulation of neuron differentiation|
|response to metal ion|
|response to oxygen levels|
|positive regulation of cell projection organization|
|regulation of protein catabolic process|
|response to oxidative stress|
|response to peptide hormone|
|regulation of apoptotic signaling pathway|
|cellular response to drug|
|regulation of cellular amide metabolic process|
|positive regulation of catabolic process|
|heterocycle catabolic process|
|negative regulation of immune system process|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|regulation of hemopoiesis|
|positive regulation of neurogenesis|
|response to peptide|
|organic cyclic compound catabolic process|
|transcription by RNA polymerase II|
|centrosome|
|regulation of body fluid levels|
|regulation of neuron projection development|
|inflammatory response|
|response to nutrient levels|
|positive regulation of cell migration|
|response to toxic substance|
|negative regulation of intracellular signal transduction|
|positive regulation of cell motility|
|ubiquitin-dependent protein catabolic process|
|response to extracellular stimulus|
|modification-dependent protein catabolic process|
|response to inorganic substance|
|positive regulation of nervous system development|
|positive regulation of cellular component movement|
|positive regulation of cell development|
|modification-dependent macromolecule catabolic process|
|positive regulation of locomotion|
|regulation of transmembrane transport|
|proteolysis involved in cellular protein catabolic process|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|cellular protein catabolic process|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|regulation of neuron differentiation|
|cellular response to nitrogen compound|
|DNA-binding transcription factor activity|
|protein catabolic process|
|protein ubiquitination|
|regulation of plasma membrane bounded cell projection organization|
|viral process|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|regulation of proteolysis|
|regulation of cellular response to stress|
|protein modification by small protein conjugation|
|symbiotic process|
|regulation of neurogenesis|
|interspecies interaction between organisms|
|regulation of cellular catabolic process|
|regulation of cell migration|
|negative regulation of apoptotic process|
|cellular homeostasis|
|cellular macromolecule catabolic process|
|negative regulation of programmed cell death|
|response to hormone|
|regulation of cell motility|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|positive regulation of cell differentiation|
|regulation of locomotion|
|Golgi apparatus|
|protein modification by small protein conjugation or removal|
|positive regulation of transport|
|regulation of cellular component movement|
|negative regulation of cell death|
|regulation of catabolic process|
|response to organonitrogen compound|
|cellular response to cytokine stimulus|
|response to drug|
|macromolecule catabolic process|
|cellular response to oxygen-containing compound|
|organonitrogen compound catabolic process|
|regulation of anatomical structure morphogenesis|
|response to nitrogen compound|
|regulation of response to external stimulus|
|nucleobase-containing compound biosynthetic process|
|response to cytokine|
|response to abiotic stimulus|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|negative regulation of signal transduction|
|proteolysis|
|organic cyclic compound biosynthetic process|
|defense response|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|DNA binding|
|response to endogenous stimulus|
|regulation of response to stress|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of programmed cell death|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|neurogenesis|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|regulation of immune system process|
|RNA metabolic process|
|regulation of cell death|
|cellular response to stress|
|positive regulation of protein metabolic process|
|cellular macromolecule biosynthetic process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|cellular catabolic process|
|regulation of cell differentiation|
|regulation of intracellular signal transduction|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|1.8|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|1.81|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|1.95|
|[[:results:exp155|UNC1999 2μM R03 exp155]]|2.06|
|[[:results:exp14|Cycloheximide 0.02μM R00 exp14]]|2.33|
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|2.56|
|[[:results:exp116|AICAR 240μM R03 exp116]]|3.09|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 17/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|3/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|2/21|
|liver|1/20|
|lung|8/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8794
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.37 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NFE2L2 Expression in NALM6 Cells: 5.37'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>