======= NID1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NID1
  * **<color #00a2e8>Official Name</color>**: nidogen 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4811|4811]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P14543|P14543]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NID1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NID1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/131390|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the nidogen family of basement membrane glycoproteins. The protein interacts with several other components of basement membranes, and may play a role in cell interactions with the extracellular matrix. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Sulfated glycoprotein widely distributed in basement membranes and tightly associated with laminin. Also binds to collagen IV and perlecan. It probably has a role in cell- extracellular matrix interactions.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|NIDO|
|Ldl recept b|
|EGF CA|
|G2F|
|cEGF|
|Thyroglobulin 1|
|EGF 3|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|laminin-1 binding|
|glomerular basement membrane development|
|proteoglycan binding|
|basement membrane organization|
|laminin binding|
|cell periphery|
|glomerulus development|
|collagen binding|
|basement membrane|
|positive regulation of cell-substrate adhesion|
|nephron development|
|cell-matrix adhesion|
|extracellular matrix structural constituent|
|cell-substrate adhesion|
|regulation of cell-substrate adhesion|
|kidney development|
|renal system development|
|urogenital system development|
|extracellular matrix organization|
|collagen-containing extracellular matrix|
|extracellular structure organization|
|positive regulation of cell adhesion|
|regulation of cell adhesion|
|calcium ion binding|
|cell adhesion|
|biological adhesion|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp346|CoCl2 18μM R07 exp346]]|-2.39|
|[[:results:exp455|Benzoate 10000μM R08 exp455]]|-2.21|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|-1.97|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|-1.78|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|-1.75|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|-1.75|
|[[:results:exp475|CyclicAMP 200μM R08 exp475]]|1.72|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|1.74|
|[[:results:exp114|A-196 10μM R03 exp114]]|1.97|
|[[:results:exp490|Hydroxychloroquine 30μM R08 exp490]]|2.14|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9009
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -3.13 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NID1 Expression in NALM6 Cells: -3.13'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>