======= NIP7 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NIP7
  * **<color #00a2e8>Official Name</color>**: nucleolar pre-rRNA processing protein NIP7
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51388|51388]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y221|Q9Y221]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NIP7&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NIP7|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/619204|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly. {ECO:0000269|PubMed:22195017}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|UPF0113|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|preribosome, large subunit precursor|
|ribosome assembly|
|ribosomal large subunit biogenesis|
|ribonucleoprotein complex assembly|
|ribonucleoprotein complex subunit organization|
|ribosome biogenesis|
|ribonucleoprotein complex biogenesis|
|organelle assembly|
|cellular protein-containing complex assembly|
|nucleolus|
|RNA binding|
|protein-containing complex assembly|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|1.79|
|[[:results:exp280|Daidzin 10μM R06 exp280]]|1.95|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.567|
|[[:human genes:p:psma7|PSMA7]]|0.513|
|[[:human genes:r:rps14|RPS14]]|0.479|
|[[:human genes:p:polr2j3|POLR2J3]]|0.458|
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.453|
|[[:human genes:r:rbm39|RBM39]]|0.439|
|[[:human genes:r:rrp1|RRP1]]|0.437|
|[[:human genes:n:narfl|NARFL]]|0.437|
|[[:human genes:r:rpl14|RPL14]]|0.433|
|[[:human genes:n:nup43|NUP43]]|0.431|
|[[:human genes:b:brd2|BRD2]]|0.431|
|[[:human genes:g:gnl3l|GNL3L]]|0.43|
|[[:human genes:p:pola2|POLA2]]|0.428|
|[[:human genes:r:rpl32|RPL32]]|0.427|
|[[:human genes:n:nol12|NOL12]]|0.427|
|[[:human genes:f:fancf|FANCF]]|0.426|
|[[:human genes:p:psmb4|PSMB4]]|0.425|
|[[:human genes:d:dido1|DIDO1]]|0.425|
|[[:human genes:r:rps11|RPS11]]|0.423|
|[[:human genes:r:rps3a|RPS3A]]|0.419|
|[[:human genes:i:ippk|IPPK]]|0.417|
|[[:human genes:m:mt1e|MT1E]]|0.416|
|[[:human genes:p:ppie|PPIE]]|0.415|
|[[:human genes:r:rps9|RPS9]]|0.414|
|[[:human genes:r:rrp15|RRP15]]|0.413|
|[[:human genes:s:scaf1|SCAF1]]|0.412|
|[[:human genes:p:psmb1|PSMB1]]|0.411|
|[[:human genes:p:psmd1|PSMD1]]|0.411|
|[[:human genes:p:pes1|PES1]]|0.41|
|[[:human genes:r:rps16|RPS16]]|0.408|
|[[:human genes:d:ddx56|DDX56]]|0.408|
|[[:human genes:r:rps12|RPS12]]|0.408|
|[[:human genes:c:c19orf53|C19orf53]]|0.407|
|[[:human genes:w:wdr43|WDR43]]|0.406|
|[[:human genes:t:taf1|TAF1]]|0.404|
|[[:human genes:n:nob1|NOB1]]|0.403|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.402|
|[[:human genes:c:cdc73|CDC73]]|0.402|
|[[:human genes:s:sf3a1|SF3A1]]|0.402|
|[[:human genes:s:smg7|SMG7]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 739/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|26/26|
|breast|33/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|20/20|
|lung|75/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 411
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.52 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NIP7 Expression in NALM6 Cells: 6.52'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>