======= NKD2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NKD2
  * **<color #00a2e8>Official Name</color>**: NKD inhibitor of WNT signaling pathway 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=85409|85409]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q969F2|Q969F2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NKD2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NKD2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607852|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity (By similarity). Required for processing of TGFA and for targeting of TGFA to the basolateral membrane of polarized epithelial cells. {ECO:0000250, ECO:0000269|PubMed:15064403, ECO:0000269|PubMed:17553928}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Golgi vesicle fusion to target membrane|
|myosin heavy chain binding|
|positive regulation of protein processing|
|positive regulation of protein maturation|
|exocytic vesicle|
|growth factor binding|
|cell periphery|
|positive regulation of protein localization to plasma membrane|
|lateral plasma membrane|
|positive regulation of protein localization to cell periphery|
|regulation of protein processing|
|regulation of protein maturation|
|vesicle fusion|
|organelle membrane fusion|
|ATPase binding|
|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|
|regulation of protein localization to plasma membrane|
|organelle fusion|
|positive regulation of ubiquitin-dependent protein catabolic process|
|positive regulation of proteasomal protein catabolic process|
|regulation of protein localization to cell periphery|
|positive regulation of proteolysis involved in cellular protein catabolic process|
|positive regulation of protein localization to membrane|
|regulation of proteasomal ubiquitin-dependent protein catabolic process|
|membrane fusion|
|positive regulation of cellular protein catabolic process|
|regulation of ubiquitin-dependent protein catabolic process|
|negative regulation of canonical Wnt signaling pathway|
|protein localization to plasma membrane|
|regulation of proteasomal protein catabolic process|
|regulation of protein localization to membrane|
|basolateral plasma membrane|
|negative regulation of Wnt signaling pathway|
|regulation of proteolysis involved in cellular protein catabolic process|
|positive regulation of protein catabolic process|
|protein localization to cell periphery|
|regulation of cellular protein catabolic process|
|cytoplasmic vesicle|
|regulation of canonical Wnt signaling pathway|
|ubiquitin protein ligase binding|
|vesicle organization|
|positive regulation of cellular protein localization|
|Wnt signaling pathway|
|positive regulation of proteolysis|
|cell-cell signaling by wnt|
|regulation of Wnt signaling pathway|
|positive regulation of cellular catabolic process|
|Golgi vesicle transport|
|regulation of protein catabolic process|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|positive regulation of catabolic process|
|protein localization to membrane|
|regulation of cellular protein localization|
|calcium ion binding|
|regulation of proteolysis|
|exocytosis|
|regulation of cellular catabolic process|
|membrane organization|
|regulation of cellular localization|
|regulation of catabolic process|
|secretion by cell|
|regulation of protein localization|
|export from cell|
|cell-cell signaling|
|secretion|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|cellular protein localization|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|positive regulation of protein metabolic process|
|vesicle-mediated transport|
|positive regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:d:ddtl|DDTL]]|0.413|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2680
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.8 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NKD2 Expression in NALM6 Cells: 2.8'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>