======= NKX2-1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NKX2-1
  * **<color #00a2e8>Official Name</color>**: NK2 homeobox 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7080|7080]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P43699|P43699]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NKX2-1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NKX2-1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600635|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein initially identified as a thyroid-specific transcription factor. The encoded protein binds to the thyroglobulin promoter and regulates the expression of thyroid-specific genes but has also been shown to regulate the expression of genes involved in morphogenesis. Mutations and deletions in this gene are associated with benign hereditary chorea, choreoathetosis, congenital hypothyroidism, and neonatal respiratory distress, and may be associated with thyroid cancer. Multiple transcript variants encoding different isoforms have been found for this gene. This gene shares the symbol/alias 'TTF1' with another gene, transcription termination factor 1, which plays a role in ribosomal gene transcription. [provided by RefSeq, Feb 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis. Forms a regulatory loop with GRHL2 that coordinates lung epithelial cell morphogenesis and differentiation. Activates the transcription of GNRHR and plays a role in enhancing the circadian oscillation of its gene expression. Represses the transcription of the circadian transcriptional repressor NR1D1 (By similarity). {ECO:0000250|UniProtKB:P23441, ECO:0000250|UniProtKB:P50220}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Homeobox|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|intronic transcription regulatory region DNA binding|
|intronic transcription regulatory region sequence-specific DNA binding|
|globus pallidus development|
|Clara cell differentiation|
|type II pneumocyte differentiation|
|forebrain dorsal/ventral pattern formation|
|lung saccule development|
|lung secretory cell differentiation|
|forebrain neuron fate commitment|
|RNA polymerase II regulatory region DNA binding|
|Leydig cell differentiation|
|cerebral cortex GABAergic interneuron differentiation|
|GABAergic neuron differentiation|
|positive regulation of circadian rhythm|
|lung epithelial cell differentiation|
|lung cell differentiation|
|thyroid gland development|
|forebrain regionalization|
|cerebral cortex neuron differentiation|
|epithelial tube branching involved in lung morphogenesis|
|negative regulation of epithelial to mesenchymal transition|
|developmental induction|
|lung epithelium development|
|lung alveolus development|
|pituitary gland development|
|cerebral cortex cell migration|
|lung morphogenesis|
|forebrain neuron differentiation|
|telencephalon cell migration|
|forebrain cell migration|
|neural nucleus development|
|neuron fate commitment|
|forebrain generation of neurons|
|oligodendrocyte differentiation|
|endoderm development|
|negative regulation of transforming growth factor beta receptor signaling pathway|
|negative regulation of cellular response to transforming growth factor beta stimulus|
|diencephalon development|
|hippocampus development|
|dorsal/ventral pattern formation|
|regulation of epithelial to mesenchymal transition|
|RNA polymerase II distal enhancer sequence-specific DNA binding|
|limbic system development|
|regulation of transforming growth factor beta receptor signaling pathway|
|regulation of circadian rhythm|
|regulation of cellular response to transforming growth factor beta stimulus|
|negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|cerebral cortex development|
|neuron migration|
|endocrine system development|
|branching morphogenesis of an epithelial tube|
|male gonad development|
|development of primary male sexual characteristics|
|negative regulation of cellular response to growth factor stimulus|
|male sex differentiation|
|morphogenesis of a branching epithelium|
|morphogenesis of a branching structure|
|lung development|
|glial cell differentiation|
|respiratory tube development|
|pallium development|
|central nervous system neuron differentiation|
|locomotory behavior|
|respiratory system development|
|transcription factor complex|
|gonad development|
|gliogenesis|
|development of primary sexual characteristics|
|transcription regulatory region DNA binding|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|cell fate commitment|
|telencephalon development|
|negative regulation of cell migration|
|axon guidance|
|neuron projection guidance|
|sex differentiation|
|regulation of cellular response to growth factor stimulus|
|negative regulation of cell motility|
|rhythmic process|
|epithelial tube morphogenesis|
|negative regulation of cellular component movement|
|RNA polymerase II regulatory region sequence-specific DNA binding|
|negative regulation of locomotion|
|regionalization|
|enzyme binding|
|axonogenesis|
|phospholipid metabolic process|
|forebrain development|
|axon development|
|gland development|
|sequence-specific DNA binding|
|reproductive structure development|
|reproductive system development|
|cell morphogenesis involved in neuron differentiation|
|morphogenesis of an epithelium|
|pattern specification process|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|cell part morphogenesis|
|chemotaxis|
|taxis|
|cell morphogenesis involved in differentiation|
|tissue morphogenesis|
|behavior|
|tube morphogenesis|
|neuron projection development|
|developmental process involved in reproduction|
|DNA-binding transcription factor activity|
|epithelial cell differentiation|
|negative regulation of cell differentiation|
|cell morphogenesis|
|brain development|
|head development|
|neuron development|
|cellular component morphogenesis|
|tube development|
|regulation of cell migration|
|negative regulation of transcription by RNA polymerase II|
|organophosphate metabolic process|
|anatomical structure formation involved in morphogenesis|
|response to hormone|
|regulation of cell motility|
|negative regulation of developmental process|
|cellular lipid metabolic process|
|animal organ morphogenesis|
|cell migration|
|central nervous system development|
|regulation of locomotion|
|regulation of cellular component movement|
|neuron differentiation|
|cell motility|
|localization of cell|
|epithelium development|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|lipid metabolic process|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|locomotion|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|negative regulation of cellular macromolecule biosynthetic process|
|reproductive process|
|reproduction|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|movement of cell or subcellular component|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|negative regulation of response to stimulus|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|tissue development|
|regulation of cell differentiation|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp446|4-Nitroquinoline-1-oxide 0.5μM R08 exp446]]|-1.81|
|[[:results:exp151|SGC0946 7μM R03 exp151]]|2|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10000
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.43 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NKX2-1 Expression in NALM6 Cells: -2.43'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>