======= NKX3-1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NKX3-1
  * **<color #00a2e8>Official Name</color>**: NK3 homeobox 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4824|4824]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q99801|Q99801]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NKX3-1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NKX3-1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602041|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells. {ECO:0000269|PubMed:19462257}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Homeobox|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|MADS box domain binding|
|regulation of androgen secretion|
|positive regulation of androgen secretion|
|negative regulation of estrogen receptor binding|
|regulation of estrogen receptor binding|
|epithelial cell proliferation involved in salivary gland morphogenesis|
|estrogen receptor activity|
|negative regulation of epithelial cell proliferation involved in prostate gland development|
|negative regulation of insulin-like growth factor receptor signaling pathway|
|dorsal aorta development|
|branching involved in prostate gland morphogenesis|
|regulation of epithelial cell proliferation involved in prostate gland development|
|positive regulation of steroid hormone secretion|
|negative regulation of receptor binding|
|cysteine-type endopeptidase activator activity involved in apoptotic process|
|mitotic cell cycle arrest|
|site of DNA damage|
|regulation of steroid hormone secretion|
|prostate gland epithelium morphogenesis|
|regulation of insulin-like growth factor receptor signaling pathway|
|regulation of receptor binding|
|prostate gland morphogenesis|
|pharyngeal system development|
|salivary gland morphogenesis|
|salivary gland development|
|androgen receptor signaling pathway|
|response to testosterone|
|protein kinase B signaling|
|prostate gland development|
|exocrine system development|
|estrogen receptor binding|
|regulation of endocrine process|
|nuclear receptor activity|
|aorta development|
|protein self-association|
|negative regulation of reproductive process|
|positive regulation of intrinsic apoptotic signaling pathway|
|positive regulation of lipid transport|
|somitogenesis|
|intracellular steroid hormone receptor signaling pathway|
|transcription regulatory region sequence-specific DNA binding|
|positive regulation of lipid localization|
|somite development|
|metanephros development|
|positive regulation of phosphatidylinositol 3-kinase signaling|
|artery development|
|positive regulation of cell division|
|epithelial cell proliferation|
|activation of cysteine-type endopeptidase activity involved in apoptotic process|
|segmentation|
|gland morphogenesis|
|positive regulation of response to DNA damage stimulus|
|negative regulation of protein binding|
|regulation of lipid transport|
|histone deacetylase binding|
|regulation of phosphatidylinositol 3-kinase signaling|
|steroid hormone mediated signaling pathway|
|negative regulation of epithelial cell proliferation|
|positive regulation of hormone secretion|
|branching morphogenesis of an epithelial tube|
|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|male gonad development|
|development of primary male sexual characteristics|
|regulation of lipid localization|
|cell cycle arrest|
|positive regulation of cysteine-type endopeptidase activity|
|positive regulation of mitotic cell cycle|
|male sex differentiation|
|morphogenesis of a branching epithelium|
|regulation of intrinsic apoptotic signaling pathway|
|regulation of reproductive process|
|intracellular receptor signaling pathway|
|morphogenesis of a branching structure|
|regulation of cell division|
|hormone-mediated signaling pathway|
|negative regulation of binding|
|positive regulation of endopeptidase activity|
|cellular response to interleukin-1|
|positive regulation of apoptotic signaling pathway|
|cellular response to hypoxia|
|cellular response to steroid hormone stimulus|
|positive regulation of peptidase activity|
|response to ketone|
|cellular response to decreased oxygen levels|
|response to interleukin-1|
|gonad development|
|cellular response to oxygen levels|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|development of primary sexual characteristics|
|anterior/posterior pattern specification|
|regulation of response to DNA damage stimulus|
|transcription regulatory region DNA binding|
|regulation of protein binding|
|cellular response to tumor necrosis factor|
|regulation of cysteine-type endopeptidase activity|
|positive regulation of DNA-binding transcription factor activity|
|response to tumor necrosis factor|
|sex differentiation|
|regulation of hormone secretion|
|kidney development|
|renal system development|
|negative regulation of mitotic cell cycle|
|epithelial tube morphogenesis|
|urogenital system development|
|response to steroid hormone|
|transcription factor binding|
|regionalization|
|regulation of epithelial cell proliferation|
|response to hypoxia|
|response to decreased oxygen levels|
|positive regulation of proteolysis|
|positive regulation of cell cycle|
|regulation of binding|
|response to oxygen levels|
|regulation of apoptotic signaling pathway|
|positive regulation of secretion by cell|
|cellular response to drug|
|gland development|
|regulation of endopeptidase activity|
|sequence-specific DNA binding|
|reproductive structure development|
|regulation of DNA-binding transcription factor activity|
|reproductive system development|
|morphogenesis of an epithelium|
|positive regulation of secretion|
|pattern specification process|
|regulation of peptidase activity|
|blood vessel development|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|vasculature development|
|cardiovascular system development|
|cellular response to lipid|
|heart development|
|regulation of hormone levels|
|cellular response to organic cyclic compound|
|cell population proliferation|
|tissue morphogenesis|
|negative regulation of cell cycle|
|regulation of system process|
|cellular response to hormone stimulus|
|regulation of mitotic cell cycle|
|chordate embryonic development|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|developmental process involved in reproduction|
|negative regulation of cell population proliferation|
|DNA-binding transcription factor activity|
|positive regulation of cell death|
|regulation of proteolysis|
|regulation of cellular response to stress|
|regulation of secretion by cell|
|positive regulation of hydrolase activity|
|regulation of secretion|
|tube development|
|response to lipid|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|response to hormone|
|positive regulation of cell population proliferation|
|response to organic cyclic compound|
|negative regulation of developmental process|
|animal organ morphogenesis|
|embryo development|
|positive regulation of transport|
|cell cycle process|
|cellular response to cytokine stimulus|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|response to drug|
|regulation of protein localization|
|positive regulation of phosphorylation|
|response to cytokine|
|epithelium development|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|negative regulation of molecular function|
|response to abiotic stimulus|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|negative regulation of RNA metabolic process|
|cell cycle|
|negative regulation of cell communication|
|negative regulation of signaling|
|negative regulation of cellular macromolecule biosynthetic process|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp16|DABN 2μM R00 exp16]]|1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5367
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.49 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NKX3-1 Expression in NALM6 Cells: -1.49'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>