======= NOL12 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NOL12
  * **<color #00a2e8>Official Name</color>**: nucleolar protein 12
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=79159|79159]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UGY1|Q9UGY1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NOL12&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NOL12|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/621385|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May bind to 28S rRNA. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Nop25|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|rRNA binding|
|nucleolus|
|RNA binding|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp100|NFN1 1μM R03 exp100]]|1.83|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|1.87|
|[[:results:exp426|FBS-Wisent 0.1 R07 exp426]]|1.92|
|[[:results:exp270|Campthothecin 0.001μM R06 exp270]]|1.95|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|2.17|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:polr2j3|POLR2J3]]|0.555|
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.555|
|[[:human genes:r:rpl6|RPL6]]|0.521|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.515|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.509|
|[[:human genes:t:tceb3c|TCEB3C]]|0.509|
|[[:human genes:r:rrp15|RRP15]]|0.508|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.503|
|[[:human genes:r:rps12|RPS12]]|0.503|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.503|
|[[:human genes:m:mcoln1|MCOLN1]]|0.494|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.485|
|[[:human genes:c:ccna2|CCNA2]]|0.477|
|[[:human genes:r:rps19bp1|RPS19BP1]]|0.475|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.469|
|[[:human genes:t:ticrr|TICRR]]|0.466|
|[[:human genes:c:cdca3|CDCA3]]|0.466|
|[[:human genes:p:pcf11|PCF11]]|0.464|
|[[:human genes:a:aqr|AQR]]|0.459|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.459|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.458|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.458|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.458|
|[[:human genes:r:rad51|RAD51]]|0.456|
|[[:human genes:r:rpl35|RPL35]]|0.455|
|[[:human genes:p:psmb4|PSMB4]]|0.454|
|[[:human genes:r:rps2|RPS2]]|0.454|
|[[:human genes:e:exosc6|EXOSC6]]|0.453|
|[[:human genes:n:npipb5|NPIPB5]]|0.452|
|[[:human genes:a:aatf|AATF]]|0.451|
|[[:human genes:t:tyms|TYMS]]|0.451|
|[[:human genes:c:chaf1a|CHAF1A]]|0.449|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.448|
|[[:human genes:d:disp2|DISP2]]|0.448|
|[[:human genes:m:myo1h|MYO1H]]|0.445|
|[[:human genes:t:tfip11|TFIP11]]|0.444|
|[[:human genes:w:wdr87|WDR87]]|0.442|
|[[:human genes:p:psmd1|PSMD1]]|0.442|
|[[:human genes:z:znf574|ZNF574]]|0.442|
|[[:human genes:m:mki67ip|MKI67IP]]|0.441|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.441|
|[[:human genes:r:rpl7a|RPL7A]]|0.439|
|[[:human genes:s:smg1|SMG1]]|0.438|
|[[:human genes:n:nol10|NOL10]]|0.437|
|[[:human genes:r:rpl15|RPL15]]|0.437|
|[[:human genes:t:taf1|TAF1]]|0.436|
|[[:human genes:u:uspl1|USPL1]]|0.436|
|[[:human genes:o:orc1|ORC1]]|0.435|
|[[:human genes:s:supt6h|SUPT6H]]|0.435|
|[[:human genes:p:psmc2|PSMC2]]|0.434|
|[[:human genes:c:copz1|COPZ1]]|0.434|
|[[:human genes:d:dtl|DTL]]|0.433|
|[[:human genes:k:krt78|KRT78]]|0.433|
|[[:human genes:h:hivep3|HIVEP3]]|0.433|
|[[:human genes:z:znf106|ZNF106]]|0.432|
|[[:human genes:p:psmc1|PSMC1]]|0.431|
|[[:human genes:o:ogfr|OGFR]]|0.431|
|[[:human genes:v:vps54|VPS54]]|0.43|
|[[:human genes:c:cactin|CACTIN]]|0.429|
|[[:human genes:m:myh2|MYH2]]|0.429|
|[[:human genes:t:tspy1|TSPY1]]|0.428|
|[[:human genes:s:sart1|SART1]]|0.427|
|[[:human genes:n:nip7|NIP7]]|0.427|
|[[:human genes:w:wdr43|WDR43]]|0.426|
|[[:human genes:u:utp20|UTP20]]|0.426|
|[[:human genes:r:rpl9|RPL9]]|0.425|
|[[:human genes:r:ranbp2|RANBP2]]|0.423|
|[[:human genes:a:atp6v1a|ATP6V1A]]|0.423|
|[[:human genes:s:sh3bp1|SH3BP1]]|0.422|
|[[:human genes:u:upf1|UPF1]]|0.422|
|[[:human genes:p:paf1|PAF1]]|0.422|
|[[:human genes:m:med14|MED14]]|0.42|
|[[:human genes:d:ddtl|DDTL]]|0.42|
|[[:human genes:a:ankle2|ANKLE2]]|0.419|
|[[:human genes:p:pole|POLE]]|0.419|
|[[:human genes:w:wdr75|WDR75]]|0.418|
|[[:human genes:s:sfpq|SFPQ]]|0.417|
|[[:human genes:v:vasn|VASN]]|0.417|
|[[:human genes:t:timeless|TIMELESS]]|0.417|
|[[:human genes:n:nup43|NUP43]]|0.417|
|[[:human genes:p:psma6|PSMA6]]|0.415|
|[[:human genes:c:cwc15|CWC15]]|0.415|
|[[:human genes:r:rfxank|RFXANK]]|0.414|
|[[:human genes:m:mdm2|MDM2]]|0.413|
|[[:human genes:g:gprin2|GPRIN2]]|0.412|
|[[:human genes:p:psmc5|PSMC5]]|0.412|
|[[:human genes:n:npipb8|NPIPB8]]|0.412|
|[[:human genes:c:chd4|CHD4]]|0.412|
|[[:human genes:z:zfand5|ZFAND5]]|0.412|
|[[:human genes:r:rpl30|RPL30]]|0.412|
|[[:human genes:g:golga8o|GOLGA8O]]|0.411|
|[[:human genes:t:twistnb|TWISTNB]]|0.41|
|[[:human genes:c:ctage4|CTAGE4]]|0.41|
|[[:human genes:r:rps5|RPS5]]|0.41|
|[[:human genes:r:rpl26|RPL26]]|0.409|
|[[:human genes:s:supt5h|SUPT5H]]|0.409|
|[[:human genes:p:ppm1d|PPM1D]]|0.408|
|[[:human genes:s:strn|STRN]]|0.408|
|[[:human genes:d:dnm2|DNM2]]|0.407|
|[[:human genes:s:sf3a3|SF3A3]]|0.406|
|[[:human genes:c:cdc45|CDC45]]|0.405|
|[[:human genes:o:osbp|OSBP]]|0.405|
|[[:human genes:n:nupl1|NUPL1]]|0.404|
|[[:human genes:r:rps3a|RPS3A]]|0.403|
|[[:human genes:s:slc6a17|SLC6A17]]|0.403|
|[[:human genes:r:rpl37a|RPL37A]]|0.401|
|[[:human genes:c:cdc6|CDC6]]|0.401|
|[[:human genes:m:mtch2|MTCH2]]|0.4|
|[[:human genes:p:polr2a|POLR2A]]|0.4|
|[[:human genes:g:gosr2|GOSR2]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 87/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|2/28|
|blood|2/28|
|bone|3/26|
|breast|2/33|
|central nervous system|13/56|
|cervix|0/4|
|colorectal|2/17|
|esophagus|3/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|2/21|
|liver|2/20|
|lung|7/75|
|lymphocyte|2/16|
|ovary|2/26|
|pancreas|4/24|
|peripheral nervous system|1/16|
|plasma cell|1/15|
|prostate|1/1|
|skin|5/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|3/22|
|urinary tract|4/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 464
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.76 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NOL12 Expression in NALM6 Cells: 4.76'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>