======= NOTCH4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NOTCH4
  * **<color #00a2e8>Official Name</color>**: notch receptor 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4855|4855]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q99466|Q99466]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NOTCH4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NOTCH4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/164951|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types. Notch signaling is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells through binding of Notch family receptors to their cognate ligands. The encoded preproprotein is proteolytically processed in the trans-Golgi network to generate two polypeptide chains that heterodimerize to form the mature cell-surface receptor. This receptor may play a role in vascular, renal and hepatic development. Mutations in this gene may be associated with schizophrenia. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|EGF|
|Ank 2|
|Ank|
|NODP|
|EGF CA|
|Notch|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of endothelial cell differentiation|
|endothelial cell morphogenesis|
|negative regulation of translation, ncRNA-mediated|
|miRNA mediated inhibition of translation|
|regulation of translation, ncRNA-mediated|
|positive regulation of transcription of Notch receptor target|
|Notch binding|
|branching involved in blood vessel morphogenesis|
|regulation of endothelial cell differentiation|
|epithelial cell morphogenesis|
|cell fate determination|
|negative regulation of epithelial cell differentiation|
|negative regulation of Notch signaling pathway|
|gene silencing by miRNA|
|endothelial cell development|
|positive regulation of Notch signaling pathway|
|posttranscriptional gene silencing by RNA|
|posttranscriptional gene silencing|
|endothelial cell differentiation|
|gene silencing by RNA|
|endothelium development|
|regulation of Notch signaling pathway|
|Notch signaling pathway|
|mammary gland development|
|negative regulation of translation|
|branching morphogenesis of an epithelial tube|
|regulation of epithelial cell differentiation|
|negative regulation of cellular amide metabolic process|
|gene silencing|
|morphogenesis of a branching epithelium|
|morphogenesis of a branching structure|
|transcription initiation from RNA polymerase II promoter|
|epithelial cell development|
|signaling receptor activity|
|DNA-templated transcription, initiation|
|regulation of gene expression, epigenetic|
|cell fate commitment|
|epithelial tube morphogenesis|
|angiogenesis|
|regulation of translation|
|regulation of cellular amide metabolic process|
|blood vessel morphogenesis|
|gland development|
|morphogenesis of an epithelium|
|wound healing|
|transcription by RNA polymerase II|
|blood vessel development|
|protein heterodimerization activity|
|vasculature development|
|cardiovascular system development|
|posttranscriptional regulation of gene expression|
|cell morphogenesis involved in differentiation|
|hemopoiesis|
|tissue morphogenesis|
|response to wounding|
|hematopoietic or lymphoid organ development|
|cell surface|
|Golgi membrane|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|immune system development|
|RNA biosynthetic process|
|tube morphogenesis|
|epithelial cell differentiation|
|negative regulation of cell differentiation|
|calcium ion binding|
|cell morphogenesis|
|cellular component morphogenesis|
|tube development|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|endoplasmic reticulum membrane|
|negative regulation of developmental process|
|negative regulation of cellular protein metabolic process|
|nucleobase-containing compound biosynthetic process|
|negative regulation of protein metabolic process|
|epithelium development|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of signal transduction|
|organic cyclic compound biosynthetic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|negative regulation of cellular macromolecule biosynthetic process|
|integral component of plasma membrane|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|negative regulation of response to stimulus|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|positive regulation of signal transduction|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|tissue development|
|macromolecule biosynthetic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp319|ABT-702 5μM plus Dimethyloxaloylglycine 11μM R07 exp319]]|-1.71|
|[[:results:exp345|Cidofovir 10μM R07 exp345]]|1.74|
|[[:results:exp406|Thalidomide 20μM R07 exp406]]|1.77|
|[[:results:exp141|Nifurtimox 1μM R03 exp141]]|1.88|
|[[:results:exp314|Dimethyloxaloylglycine 11μM R07 exp314]]|1.95|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6160
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.5 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NOTCH4 Expression in NALM6 Cells: 3.5'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>