======= NOX1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NOX1
  * **<color #00a2e8>Official Name</color>**: N/ADPH oxidase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=27035|27035]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y5S8|Q9Y5S8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NOX1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NOX1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300225|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the NADPH oxidase family of enzymes responsible for the catalytic one-electron transfer of oxygen to generate superoxide or hydrogen peroxide. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**:  NOH-1S is a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes and other tissues. It participates in the regulation of cellular pH and is blocked by zinc. NOH-1L is a pyridine nucleotide-dependent oxidoreductase that generates superoxide and might conduct H(+) ions as part of its electron transport mechanism, whereas NOH-1S does not contain an electron transport chain.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ferric reduct|
|NAD binding 6|
|FAD binding 8|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cellular stress response to acidic pH|
|oxygen metabolic process|
|positive regulation of integrin biosynthetic process|
|regulation of integrin biosynthetic process|
|invadopodium membrane|
|positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway|
|intracellular pH elevation|
|cellular response to hyperoxia|
|pH elevation|
|superoxide-generating NADPH oxidase activity|
|cellular response to acidic pH|
|cellular response to increased oxygen levels|
|NADPH oxidase complex|
|regulation of plasma membrane organization|
|positive regulation of oxidative stress-induced cell death|
|superoxide anion generation|
|positive regulation of cellular response to oxidative stress|
|positive regulation of response to oxidative stress|
|respiratory burst|
|response to hyperoxia|
|regulation of systemic arterial blood pressure by renin-angiotensin|
|cellular response to pH|
|response to acidic pH|
|regulation of oxidative stress-induced intrinsic apoptotic signaling pathway|
|positive regulation of vascular endothelial growth factor production|
|response to increased oxygen levels|
|NADP metabolic process|
|regulation of vascular endothelial growth factor production|
|regulation of systemic arterial blood pressure by hormone|
|NADP binding|
|hydrogen peroxide metabolic process|
|superoxide metabolic process|
|response to pH|
|voltage-gated ion channel activity|
|regulation of systemic arterial blood pressure mediated by a chemical signal|
|endocrine process|
|Rac GTPase binding|
|positive regulation of intrinsic apoptotic signaling pathway|
|regulation of oxidative stress-induced cell death|
|regulation of cellular response to oxidative stress|
|regulation of intracellular pH|
|regulation of response to oxidative stress|
|positive regulation of smooth muscle cell proliferation|
|regulation of cellular pH|
|regulation of systemic arterial blood pressure|
|regulation of pH|
|antibiotic metabolic process|
|cellular monovalent inorganic cation homeostasis|
|reactive oxygen species metabolic process|
|regulation of smooth muscle cell proliferation|
|positive regulation of JNK cascade|
|monovalent inorganic cation homeostasis|
|regulation of intrinsic apoptotic signaling pathway|
|positive regulation of stress-activated MAPK cascade|
|positive regulation of stress-activated protein kinase signaling cascade|
|positive regulation of apoptotic signaling pathway|
|regulation of blood pressure|
|regulation of JNK cascade|
|cellular response to oxygen levels|
|regulation of stress-activated MAPK cascade|
|regulation of stress-activated protein kinase signaling cascade|
|early endosome|
|cellular response to abiotic stimulus|
|cellular response to environmental stimulus|
|angiogenesis|
|extracellular matrix organization|
|response to oxygen levels|
|extracellular structure organization|
|blood circulation|
|circulatory system process|
|regulation of apoptotic signaling pathway|
|blood vessel morphogenesis|
|cofactor metabolic process|
|positive regulation of cytokine production|
|regulation of ion transmembrane transport|
|blood vessel development|
|inflammatory response|
|drug metabolic process|
|vasculature development|
|cardiovascular system development|
|positive regulation of MAPK cascade|
|cell junction|
|regulation of transmembrane transport|
|cellular cation homeostasis|
|positive regulation of apoptotic process|
|cellular ion homeostasis|
|positive regulation of programmed cell death|
|tube morphogenesis|
|regulation of cytokine production|
|positive regulation of cell death|
|regulation of ion transport|
|cation homeostasis|
|inorganic ion homeostasis|
|regulation of cellular response to stress|
|cellular chemical homeostasis|
|regulation of MAPK cascade|
|ion homeostasis|
|tube development|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|cellular homeostasis|
|positive regulation of cell population proliferation|
|ion transmembrane transport|
|oxidation-reduction process|
|cell migration|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|positive regulation of phosphorylation|
|localization of cell|
|cell motility|
|chemical homeostasis|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|response to abiotic stimulus|
|positive regulation of cellular component organization|
|positive regulation of protein modification process|
|transmembrane transport|
|locomotion|
|defense response|
|ion transport|
|regulation of protein phosphorylation|
|regulation of response to stress|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|homeostatic process|
|positive regulation of signal transduction|
|regulation of cell death|
|cellular response to stress|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
|positive regulation of macromolecule biosynthetic process|
|system process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7161
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.0 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NOX1 Expression in NALM6 Cells: 0.0'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>