======= NOX4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NOX4
  * **<color #00a2e8>Official Name</color>**: N/ADPH oxidase 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=50507|50507]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NPH5|Q9NPH5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NOX4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NOX4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605261|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|FAD binding 8|
|NAD binding 6|
|Ferric reduct|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|oxygen sensor activity|
|modified amino acid binding|
|NAD(P)H oxidase activity|
|superoxide-generating NADPH oxidase activity|
|homocysteine metabolic process|
|NADPH oxidase complex|
|superoxide anion generation|
|perinuclear endoplasmic reticulum|
|bone resorption|
|reactive oxygen species biosynthetic process|
|protein tyrosine kinase binding|
|cellular response to gamma radiation|
|positive regulation of smooth muscle cell migration|
|superoxide metabolic process|
|sulfur amino acid metabolic process|
|bone remodeling|
|positive regulation of stress fiber assembly|
|cellular response to cAMP|
|positive regulation of protein tyrosine kinase activity|
|response to gamma radiation|
|flavin adenine dinucleotide binding|
|regulation of smooth muscle cell migration|
|positive regulation of actin filament bundle assembly|
|nucleotide binding|
|cell aging|
|positive regulation of DNA biosynthetic process|
|stress fiber|
|cellular response to ionizing radiation|
|cellular response to glucose stimulus|
|cellular response to hexose stimulus|
|cellular response to monosaccharide stimulus|
|electron transfer activity|
|regulation of stress fiber assembly|
|cellular response to carbohydrate stimulus|
|cellular glucose homeostasis|
|cardiac muscle cell differentiation|
|regulation of protein tyrosine kinase activity|
|regulation of actomyosin structure organization|
|regulation of actin filament bundle assembly|
|positive regulation of reactive oxygen species metabolic process|
|response to cAMP|
|heart process|
|tissue remodeling|
|reactive oxygen species metabolic process|
|regulation of DNA biosynthetic process|
|cardiocyte differentiation|
|response to organophosphorus|
|response to glucose|
|heme binding|
|response to hexose|
|response to monosaccharide|
|response to ionizing radiation|
|response to purine-containing compound|
|cellular response to transforming growth factor beta stimulus|
|response to transforming growth factor beta|
|cardiac muscle tissue development|
|positive regulation of protein kinase B signaling|
|response to carbohydrate|
|cellular response to radiation|
|regulation of reactive oxygen species metabolic process|
|electron transport chain|
|glucose homeostasis|
|carbohydrate homeostasis|
|tissue homeostasis|
|positive regulation of peptidyl-tyrosine phosphorylation|
|positive regulation of DNA metabolic process|
|positive regulation of supramolecular fiber organization|
|striated muscle cell differentiation|
|alpha-amino acid metabolic process|
|positive regulation of ERK1 and ERK2 cascade|
|positive regulation of cytoskeleton organization|
|regulation of protein kinase B signaling|
|cellular response to oxidative stress|
|muscle cell differentiation|
|regulation of peptidyl-tyrosine phosphorylation|
|regulation of actin filament organization|
|positive regulation of MAP kinase activity|
|aging|
|striated muscle tissue development|
|regulation of ERK1 and ERK2 cascade|
|muscle tissue development|
|cellular amino acid metabolic process|
|cellular response to environmental stimulus|
|cellular response to abiotic stimulus|
|apical plasma membrane|
|multicellular organismal homeostasis|
|positive regulation of protein serine/threonine kinase activity|
|anatomical structure homeostasis|
|regulation of MAP kinase activity|
|regulation of actin cytoskeleton organization|
|response to hypoxia|
|regulation of supramolecular fiber organization|
|regulation of DNA metabolic process|
|response to decreased oxygen levels|
|sulfur compound metabolic process|
|response to oxygen levels|
|response to oxidative stress|
|regulation of actin filament-based process|
|circulatory system process|
|focal adhesion|
|generation of precursor metabolites and energy|
|response to radiation|
|muscle structure development|
|inflammatory response|
|cellular response to growth factor stimulus|
|positive regulation of cell migration|
|regulation of protein serine/threonine kinase activity|
|positive regulation of cellular component biogenesis|
|positive regulation of cell motility|
|heart development|
|response to growth factor|
|positive regulation of protein kinase activity|
|positive regulation of cellular component movement|
|regulation of cytoskeleton organization|
|cellular response to organic cyclic compound|
|positive regulation of MAPK cascade|
|positive regulation of locomotion|
|positive regulation of kinase activity|
|cellular response to organonitrogen compound|
|positive regulation of organelle organization|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|positive regulation of transferase activity|
|cellular response to nitrogen compound|
|negative regulation of cell population proliferation|
|perinuclear region of cytoplasm|
|positive regulation of cell death|
|cell morphogenesis|
|cellular chemical homeostasis|
|regulation of MAPK cascade|
|regulation of protein kinase activity|
|cellular component morphogenesis|
|regulation of cell migration|
|nucleolus|
|circulatory system development|
|regulation of kinase activity|
|cellular homeostasis|
|carboxylic acid metabolic process|
|regulation of cell motility|
|response to organic cyclic compound|
|endoplasmic reticulum membrane|
|regulation of cellular component biogenesis|
|oxidation-reduction process|
|regulation of transferase activity|
|regulation of locomotion|
|regulation of cellular component movement|
|response to organonitrogen compound|
|oxoacid metabolic process|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|organic acid metabolic process|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|response to nitrogen compound|
|chemical homeostasis|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|response to abiotic stimulus|
|positive regulation of cellular component organization|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|mitochondrion|
|regulation of organelle organization|
|defense response|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|homeostatic process|
|positive regulation of signal transduction|
|regulation of cell death|
|cellular response to stress|
|positive regulation of protein metabolic process|
|small molecule metabolic process|
|tissue development|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|system process|
|positive regulation of cellular biosynthetic process|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16874
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.3 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NOX4 Expression in NALM6 Cells: 1.3'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>