======= NPHS2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NPHS2
  * **<color #00a2e8>Official Name</color>**: NPHS2 stomatin family member, podocin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7827|7827]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NP85|Q9NP85]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NPHS2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NPHS2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604766|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein that plays a role in the regulation of glomerular permeability. Mutations in this gene cause steroid-resistant nephrotic syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role in the regulation of glomerular permeability, acting probably as a linker between the plasma membrane and the cytoskeleton.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Band 7|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|metanephric glomerular visceral epithelial cell differentiation|
|metanephric glomerular epithelium development|
|metanephric glomerular epithelial cell development|
|metanephric glomerular visceral epithelial cell development|
|metanephric glomerular epithelial cell differentiation|
|intrinsic component of the cytoplasmic side of the plasma membrane|
|glomerular visceral epithelial cell development|
|slit diaphragm|
|metanephric glomerulus development|
|glomerular epithelial cell development|
|glomerular visceral epithelial cell differentiation|
|renal filtration cell differentiation|
|metanephric nephron epithelium development|
|glomerular epithelial cell differentiation|
|cell differentiation involved in metanephros development|
|glomerular epithelium development|
|metanephric epithelium development|
|epithelial cell differentiation involved in kidney development|
|metanephric nephron development|
|cell differentiation involved in kidney development|
|excretion|
|glomerulus development|
|actin cytoskeleton reorganization|
|metanephros development|
|nephron epithelium development|
|nephron development|
|kidney epithelium development|
|cell-cell junction|
|epithelial cell development|
|membrane raft|
|kidney development|
|renal system development|
|urogenital system development|
|actin cytoskeleton organization|
|actin filament-based process|
|protein-containing complex|
|epithelial cell differentiation|
|endoplasmic reticulum|
|cytoskeleton organization|
|epithelium development|
|integral component of plasma membrane|
|cell development|
|tissue development|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp121|Golgicide-A 2μM R03 exp121]]|-1.89|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|1.77|
|[[:results:exp281|Disulfiram 4.3μM R06 exp281]]|1.82|
|[[:results:exp311|2-Methoxyestradiol 0.55 to 0.75μM  on day4 R07 exp311]]|1.93|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|1.96|
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|2.26|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7049
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NPHS2 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>