======= NPM1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NPM1
  * **<color #00a2e8>Official Name</color>**: nucleophosmin 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4869|4869]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P06748|P06748]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NPM1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NPM1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/164040|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is involved in several cellular processes, including centrosome duplication, protein chaperoning, and cell proliferation. The encoded phosphoprotein shuttles between the nucleolus, nucleus, and cytoplasm, chaperoning ribosomal proteins and core histones from the nucleus to the cytoplasm. This protein is also known to sequester the tumor suppressor ARF in the nucleolus, protecting it from degradation until it is needed. Mutations in this gene are associated with acute myeloid leukemia. Dozens of pseudogenes of this gene have been identified. [provided by RefSeq, Aug 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Nucleoplasmin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of eIF2 alpha phosphorylation by dsRNA|
|regulation of mRNA stability involved in cellular response to UV|
|rRNA export from nucleus|
|regulation of endoribonuclease activity|
|rRNA transport|
|ribosomal small subunit export from nucleus|
|negative regulation of protein kinase activity by regulation of protein phosphorylation|
|regulation of endodeoxyribonuclease activity|
|ribosomal large subunit export from nucleus|
|regulation of ribonuclease activity|
|Tat protein binding|
|regulation of deoxyribonuclease activity|
|negative regulation of centrosome duplication|
|ribosome localization|
|ribosomal large subunit binding|
|core promoter binding|
|ribosomal subunit export from nucleus|
|rRNA-containing ribonucleoprotein complex export from nucleus|
|negative regulation of centrosome cycle|
|spindle pole centrosome|
|ribosomal small subunit binding|
|regulation of centriole replication|
|regulation of nuclease activity|
|cellular response to dsRNA|
|protein kinase inhibitor activity|
|NF-kappaB binding|
|positive regulation of cell cycle G2/M phase transition|
|CENP-A containing chromatin organization|
|CENP-A containing nucleosome assembly|
|activating transcription factor binding|
|chromatin remodeling at centromere|
|ncRNA export from nucleus|
|centromere complex assembly|
|DNA replication-independent nucleosome assembly|
|DNA replication-independent nucleosome organization|
|regulation of centrosome duplication|
|protein-DNA complex|
|histone exchange|
|response to dsRNA|
|regulation of centrosome cycle|
|cell aging|
|ribosome assembly|
|ribosomal small subunit biogenesis|
|ribosomal large subunit biogenesis|
|ATP-dependent chromatin remodeling|
|regulation of translational initiation|
|centrosome cycle|
|cellular response to UV|
|microtubule organizing center organization|
|positive regulation of cell cycle phase transition|
|cellular response to light stimulus|
|nucleosome assembly|
|ribonucleoprotein complex export from nucleus|
|positive regulation of translation|
|ribonucleoprotein complex localization|
|RNA export from nucleus|
|histone binding|
|unfolded protein binding|
|chromatin assembly|
|negative regulation of cytoskeleton organization|
|response to UV|
|protein export from nucleus|
|positive regulation of cellular amide metabolic process|
|positive regulation of NF-kappaB transcription factor activity|
|ribonucleoprotein complex|
|chromatin assembly or disassembly|
|nucleosome organization|
|nuclear export|
|chromatin remodeling|
|cellular response to radiation|
|DNA packaging|
|regulation of mRNA stability|
|regulation of RNA stability|
|regulation of microtubule cytoskeleton organization|
|RNA transport|
|nucleic acid transport|
|establishment of RNA localization|
|protein-DNA complex assembly|
|regulation of mRNA catabolic process|
|regulation of cell cycle G2/M phase transition|
|RNA localization|
|regulation of organelle assembly|
|regulation of microtubule-based process|
|negative regulation of protein kinase activity|
|ribonucleoprotein complex assembly|
|nucleobase-containing compound transport|
|protein-DNA complex subunit organization|
|ribonucleoprotein complex subunit organization|
|negative regulation of kinase activity|
|protein-containing complex localization|
|positive regulation of DNA-binding transcription factor activity|
|nucleocytoplasmic transport|
|nuclear transport|
|negative regulation of transferase activity|
|aging|
|transcription coactivator activity|
|positive regulation of cell cycle process|
|DNA conformation change|
|ribosome biogenesis|
|response to light stimulus|
|cellular response to environmental stimulus|
|cellular response to abiotic stimulus|
|negative regulation of cell cycle process|
|regulation of mRNA metabolic process|
|transcription factor binding|
|regulation of translation|
|regulation of DNA metabolic process|
|establishment of organelle localization|
|negative regulation of organelle organization|
|positive regulation of cell cycle|
|chromatin binding|
|regulation of cellular amide metabolic process|
|negative regulation of protein phosphorylation|
|focal adhesion|
|regulation of DNA-binding transcription factor activity|
|response to radiation|
|negative regulation of phosphorylation|
|regulation of cell cycle phase transition|
|ribonucleoprotein complex biogenesis|
|protein kinase binding|
|microtubule cytoskeleton organization|
|protein heterodimerization activity|
|centrosome|
|DNA repair|
|protein complex oligomerization|
|posttranscriptional regulation of gene expression|
|regulation of cytoskeleton organization|
|cellular response to organic cyclic compound|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|negative regulation of cell cycle|
|organelle localization|
|negative regulation of protein modification process|
|protein-containing complex|
|cellular response to nitrogen compound|
|microtubule-based process|
|negative regulation of cell population proliferation|
|chromatin organization|
|viral process|
|negative regulation of cellular component organization|
|regulation of cellular response to stress|
|DNA metabolic process|
|regulation of cell cycle process|
|organelle assembly|
|cellular response to DNA damage stimulus|
|symbiotic process|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|interspecies interaction between organisms|
|regulation of cellular catabolic process|
|cellular protein-containing complex assembly|
|nucleolus|
|regulation of kinase activity|
|protein homodimerization activity|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|positive regulation of cell population proliferation|
|response to organic cyclic compound|
|regulation of cellular component biogenesis|
|regulation of transferase activity|
|intracellular protein transport|
|negative regulation of cell death|
|regulation of catabolic process|
|cell cycle process|
|negative regulation of cellular protein metabolic process|
|chromosome organization|
|response to nitrogen compound|
|negative regulation of protein metabolic process|
|cytoskeleton organization|
|negative regulation of molecular function|
|response to abiotic stimulus|
|regulation of cell cycle|
|positive regulation of transcription by RNA polymerase II|
|regulation of hydrolase activity|
|regulation of organelle organization|
|cell cycle|
|RNA binding|
|regulation of protein phosphorylation|
|regulation of response to stress|
|protein transport|
|intracellular transport|
|peptide transport|
|regulation of apoptotic process|
|positive regulation of transcription, DNA-templated|
|protein-containing complex assembly|
|regulation of programmed cell death|
|amide transport|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|regulation of cell population proliferation|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|regulation of cell death|
|cellular response to stress|
|positive regulation of protein metabolic process|
|positive regulation of RNA metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|membrane|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|-1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:polr2j3|POLR2J3]]|0.414|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 39/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|2/28|
|blood|0/28|
|bone|3/25|
|breast|2/33|
|central nervous system|7/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|3/21|
|liver|1/20|
|lung|2/75|
|lymphocyte|1/14|
|ovary|2/26|
|pancreas|1/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|4/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1340
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 10.29 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NPM1 Expression in NALM6 Cells: 10.29'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>