======= NPPC =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NPPC
  * **<color #00a2e8>Official Name</color>**: natriuretic peptide C
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4880|4880]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P23582|P23582]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NPPC&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NPPC|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600296|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation. May also be vasoactive and natriuretic. Specifically binds and stimulates the cGMP production of the NPR2 receptor. Binds the clearance receptor NPR3 (By similarity). {ECO:0000250, ECO:0000269|PubMed:1672777}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ANP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|growth plate cartilage chondrocyte proliferation|
|negative regulation of oocyte maturation|
|negative regulation of oocyte development|
|negative regulation of oogenesis|
|hormone receptor binding|
|regulation of oocyte maturation|
|positive regulation of cGMP-mediated signaling|
|negative regulation of cell maturation|
|regulation of oocyte development|
|negative regulation of collagen biosynthetic process|
|regulation of oogenesis|
|receptor guanylyl cyclase signaling pathway|
|negative regulation of collagen metabolic process|
|cGMP biosynthetic process|
|regulation of cGMP-mediated signaling|
|negative regulation of meiotic cell cycle|
|cGMP metabolic process|
|regulation of cell maturation|
|cyclic nucleotide biosynthetic process|
|cyclic purine nucleotide metabolic process|
|growth plate cartilage chondrocyte differentiation|
|cGMP-mediated signaling|
|chondrocyte differentiation involved in endochondral bone morphogenesis|
|growth plate cartilage development|
|regulation of collagen biosynthetic process|
|negative regulation of DNA biosynthetic process|
|regulation of collagen metabolic process|
|cyclic nucleotide metabolic process|
|endochondral bone growth|
|cartilage development involved in endochondral bone morphogenesis|
|bone growth|
|regulation of meiotic cell cycle|
|negative regulation of reproductive process|
|positive regulation of blood vessel diameter|
|positive regulation of osteoblast differentiation|
|regulation of multicellular organism growth|
|regulation of cardiac conduction|
|endochondral bone morphogenesis|
|chondrocyte differentiation|
|positive regulation of ossification|
|secretory granule|
|post-embryonic development|
|organ growth|
|hormone activity|
|regulation of DNA biosynthetic process|
|regulation of osteoblast differentiation|
|bone morphogenesis|
|negative regulation of DNA metabolic process|
|response to ethanol|
|regulation of smooth muscle cell proliferation|
|regulation of tube diameter|
|regulation of blood vessel diameter|
|regulation of tube size|
|purine ribonucleotide biosynthetic process|
|purine nucleotide biosynthetic process|
|regulation of reproductive process|
|ribonucleotide biosynthetic process|
|vascular process in circulatory system|
|ribose phosphate biosynthetic process|
|purine-containing compound biosynthetic process|
|cyclic-nucleotide-mediated signaling|
|cartilage development|
|regulation of ossification|
|bone development|
|negative regulation of multi-organism process|
|connective tissue development|
|protein folding|
|response to alcohol|
|skeletal system morphogenesis|
|regulation of heart contraction|
|nucleotide biosynthetic process|
|nucleoside phosphate biosynthetic process|
|ossification|
|regulation of blood circulation|
|response to antibiotic|
|purine ribonucleotide metabolic process|
|ribonucleotide metabolic process|
|regulation of developmental growth|
|purine nucleotide metabolic process|
|negative regulation of cell development|
|ribose phosphate metabolic process|
|signaling receptor binding|
|second-messenger-mediated signaling|
|response to hypoxia|
|regulation of DNA metabolic process|
|response to decreased oxygen levels|
|purine-containing compound metabolic process|
|response to oxygen levels|
|developmental growth|
|blood circulation|
|growth|
|circulatory system process|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|skeletal system development|
|response to toxic substance|
|regulation of anatomical structure size|
|organophosphate biosynthetic process|
|nucleobase-containing small molecule metabolic process|
|cell population proliferation|
|negative regulation of cell cycle|
|regulation of system process|
|protein-containing complex|
|carbohydrate derivative biosynthetic process|
|regulation of growth|
|negative regulation of cell population proliferation|
|negative regulation of cell differentiation|
|enzyme linked receptor protein signaling pathway|
|regulation of multi-organism process|
|organophosphate metabolic process|
|regulation of cell development|
|negative regulation of developmental process|
|animal organ morphogenesis|
|positive regulation of cell differentiation|
|positive regulation of intracellular signal transduction|
|response to drug|
|carbohydrate derivative metabolic process|
|nucleobase-containing compound biosynthetic process|
|response to abiotic stimulus|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|regulation of cell cycle|
|negative regulation of multicellular organismal process|
|organic cyclic compound biosynthetic process|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|organonitrogen compound biosynthetic process|
|reproductive process|
|reproduction|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|extracellular space|
|regulation of cell population proliferation|
|cellular nitrogen compound biosynthetic process|
|positive regulation of signal transduction|
|intracellular signal transduction|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|tissue development|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|extracellular region|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|-1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:prim1|PRIM1]]|0.519|
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.405|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16442
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -3.21 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NPPC Expression in NALM6 Cells: -3.21'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>