======= NQO1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NQO1
  * **<color #00a2e8>Official Name</color>**: N/AD(P)H quinone dehydrogenase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1728|1728]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P15559|P15559]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NQO1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NQO1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/125860|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. This protein's enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Mutations in this gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered expression of this protein has been seen in many tumors and is also associated with Alzheimer's disease (AD). Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Flavodoxin 2|
|FMN red|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|NAD(P)H dehydrogenase (quinone) activity|
|response to hydrogen sulfide|
|superoxide dismutase activity|
|cytochrome-b5 reductase activity, acting on NAD(P)H|
|removal of superoxide radicals|
|nitric oxide biosynthetic process|
|cellular response to superoxide|
|cellular response to oxygen radical|
|response to superoxide|
|nitric oxide metabolic process|
|response to oxygen radical|
|reactive nitrogen species metabolic process|
|reactive oxygen species biosynthetic process|
|synaptic transmission, cholinergic|
|superoxide metabolic process|
|neurotransmitter biosynthetic process|
|response to electrical stimulus|
|positive regulation of neuron apoptotic process|
|regulation of cellular amino acid metabolic process|
|cellular response to hydrogen peroxide|
|electron transfer activity|
|regulation of cellular amine metabolic process|
|cellular oxidant detoxification|
|neurotransmitter metabolic process|
|positive regulation of neuron death|
|cellular detoxification|
|reactive oxygen species metabolic process|
|cellular response to antibiotic|
|oxidoreductase activity|
|response to hydrogen peroxide|
|response to ethanol|
|detoxification|
|xenobiotic metabolic process|
|cellular response to reactive oxygen species|
|response to estradiol|
|regulation of cellular ketone metabolic process|
|electron transport chain|
|cellular response to xenobiotic stimulus|
|cellular response to metal ion|
|response to reactive oxygen species|
|regulation of neuron apoptotic process|
|cellular response to toxic substance|
|response to nutrient|
|cellular response to inorganic substance|
|response to alcohol|
|cellular response to oxidative stress|
|aging|
|response to xenobiotic stimulus|
|response to antibiotic|
|regulation of neuron death|
|response to acid chemical|
|regulation of neurotransmitter levels|
|response to metal ion|
|neuronal cell body|
|response to oxidative stress|
|cellular response to drug|
|chemical synaptic transmission|
|dendrite|
|anterograde trans-synaptic signaling|
|generation of precursor metabolites and energy|
|regulation of small molecule metabolic process|
|trans-synaptic signaling|
|synaptic signaling|
|response to nutrient levels|
|drug metabolic process|
|response to toxic substance|
|response to extracellular stimulus|
|response to inorganic substance|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|positive regulation of cell death|
|negative regulation of catalytic activity|
|response to lipid|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|response to hormone|
|response to organic cyclic compound|
|oxidation-reduction process|
|negative regulation of cell death|
|response to drug|
|cellular response to oxygen-containing compound|
|identical protein binding|
|response to nitrogen compound|
|cell-cell signaling|
|negative regulation of molecular function|
|response to abiotic stimulus|
|RNA binding|
|response to endogenous stimulus|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|cellular nitrogen compound biosynthetic process|
|regulation of cell death|
|cellular response to stress|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp298|Sucrose 20000μM R06 exp298]]|-2.23|
|[[:results:exp218|A-395 10μM R05 exp218]]|-2.21|
|[[:results:exp156|UNC2400 2μM R03 exp156]]|-2.16|
|[[:results:exp464|Calcipotriol 5μM R08 exp464]]|-1.79|
|[[:results:exp107|UMK57 0.6μM R03 exp107]]|-1.76|
|[[:results:exp345|Cidofovir 10μM R07 exp345]]|1.73|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|1.81|
|[[:results:exp236|GSK2606414 1μM R05 exp236]]|1.85|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|2.1|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10546
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.8 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NQO1 Expression in NALM6 Cells: 2.8'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>