======= NR4A2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NR4A2
  * **<color #00a2e8>Official Name</color>**: nuclear receptor subfamily 4 group A member 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4929|4929]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P43354|P43354]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NR4A2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NR4A2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601828|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson disease, schizophernia, and manic depression. Misregulation of this gene may be associated with rheumatoid arthritis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons (By similarity). {ECO:0000250, ECO:0000269|PubMed:17184956}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-C4|
|Hormone recep|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|general adaptation syndrome|
|epithalamus development|
|habenula development|
|response to corticotropin-releasing hormone|
|cellular response to corticotropin-releasing hormone stimulus|
|dopamine biosynthetic process|
|midbrain dopaminergic neuron differentiation|
|glucocorticoid receptor binding|
|retinoid X receptor binding|
|catecholamine biosynthetic process|
|catechol-containing compound biosynthetic process|
|regulation of dopamine metabolic process|
|regulation of catecholamine metabolic process|
|regulation of respiratory gaseous exchange|
|central nervous system projection neuron axonogenesis|
|dopamine metabolic process|
|dopaminergic neuron differentiation|
|response to amphetamine|
|phenol-containing compound biosynthetic process|
|central nervous system neuron axonogenesis|
|neuron maturation|
|catechol-containing compound metabolic process|
|catecholamine metabolic process|
|response to amine|
|nuclear receptor activity|
|response to bronchodilator|
|steroid hormone receptor activity|
|multicellular organismal response to stress|
|diencephalon development|
|adult locomotory behavior|
|regulation of cellular amine metabolic process|
|central nervous system neuron development|
|beta-catenin binding|
|phenol-containing compound metabolic process|
|midbrain development|
|post-embryonic development|
|canonical Wnt signaling pathway|
|fat cell differentiation|
|steroid hormone mediated signaling pathway|
|neuron migration|
|anatomical structure maturation|
|adult behavior|
|negative regulation of neuron apoptotic process|
|cell maturation|
|intracellular receptor signaling pathway|
|hormone-mediated signaling pathway|
|transcription initiation from RNA polymerase II promoter|
|central nervous system neuron differentiation|
|organic hydroxy compound biosynthetic process|
|cellular response to steroid hormone stimulus|
|ammonium ion metabolic process|
|locomotory behavior|
|transcription factor complex|
|negative regulation of neuron death|
|regulation of neuron apoptotic process|
|DNA-templated transcription, initiation|
|negative regulation of apoptotic signaling pathway|
|cellular response to oxidative stress|
|developmental maturation|
|cellular response to extracellular stimulus|
|cellular response to peptide hormone stimulus|
|response to xenobiotic stimulus|
|regulation of neuron death|
|RNA polymerase II regulatory region sequence-specific DNA binding|
|cellular response to peptide|
|response to steroid hormone|
|cellular response to external stimulus|
|response to hypoxia|
|response to decreased oxygen levels|
|cell-cell signaling by wnt|
|Wnt signaling pathway|
|axonogenesis|
|response to oxygen levels|
|response to oxidative stress|
|forebrain development|
|response to peptide hormone|
|regulation of apoptotic signaling pathway|
|nuclear speck|
|axon development|
|sequence-specific DNA binding|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|cell morphogenesis involved in neuron differentiation|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|organic hydroxy compound metabolic process|
|response to peptide|
|neuron projection morphogenesis|
|transcription by RNA polymerase II|
|plasma membrane bounded cell projection morphogenesis|
|protein heterodimerization activity|
|cell projection morphogenesis|
|drug metabolic process|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|response to toxic substance|
|cell part morphogenesis|
|cellular response to lipid|
|response to extracellular stimulus|
|cellular response to organic cyclic compound|
|cell morphogenesis involved in differentiation|
|behavior|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|cellular response to nitrogen compound|
|neuron projection development|
|cell morphogenesis|
|brain development|
|head development|
|neuron development|
|cellular component morphogenesis|
|zinc ion binding|
|response to lipid|
|negative regulation of transcription by RNA polymerase II|
|protein homodimerization activity|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|response to hormone|
|response to organic cyclic compound|
|cell migration|
|central nervous system development|
|negative regulation of cell death|
|response to organonitrogen compound|
|neuron differentiation|
|response to drug|
|cellular response to oxygen-containing compound|
|cell motility|
|localization of cell|
|response to nitrogen compound|
|nucleobase-containing compound biosynthetic process|
|cell-cell signaling|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|response to abiotic stimulus|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|negative regulation of transcription, DNA-templated|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|organic cyclic compound biosynthetic process|
|locomotion|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|negative regulation of cellular macromolecule biosynthetic process|
|organonitrogen compound biosynthetic process|
|positive regulation of catalytic activity|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|regulation of apoptotic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of programmed cell death|
|negative regulation of response to stimulus|
|neurogenesis|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|RNA metabolic process|
|regulation of cell death|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|macromolecule biosynthetic process|
|positive regulation of molecular function|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|-1.75|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|-1.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8880
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.03 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NR4A2 Expression in NALM6 Cells: 1.03'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>