======= NR4A3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NR4A3
  * **<color #00a2e8>Official Name</color>**: nuclear receptor subfamily 4 group A member 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8013|8013]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q92570|Q92570]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NR4A3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NR4A3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600542|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcriptional activator. The protein can efficiently bind the NGFI-B Response Element (NBRE). Three different versions of extraskeletal myxoid chondrosarcomas (EMCs) are the result of reciprocal translocations between this gene and other genes. The translocation breakpoints are associated with Nuclear Receptor Subfamily 4, Group A, Member 3 (on chromosome 9) and either Ewing Sarcome Breakpoint Region 1 (on chromosome 22), RNA Polymerase II, TATA Box-Binding Protein-Associated Factor, 68-KD (on chromosome 17), or Transcription factor 12 (on chromosome 15). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-C4|
|Hormone recep|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of mast cell activation by Fc-epsilon receptor signaling pathway|
|pyruvate oxidation|
|regulation of monocyte aggregation|
|positive regulation of mast cell cytokine production|
|positive regulation of monocyte aggregation|
|vestibular reflex|
|cellular response to corticotropin-releasing hormone stimulus|
|regulation of mast cell cytokine production|
|response to corticotropin-releasing hormone|
|negative regulation of hydrogen peroxide-induced neuron death|
|regulation of hydrogen peroxide-induced neuron death|
|semicircular canal morphogenesis|
|common myeloid progenitor cell proliferation|
|semicircular canal development|
|positive regulation of feeding behavior|
|regulation of type B pancreatic cell proliferation|
|cAMP response element binding|
|positive regulation of fatty acid oxidation|
|negative regulation of response to reactive oxygen species|
|positive regulation of vascular associated smooth muscle cell migration|
|glucocorticoid receptor binding|
|negative regulation of hydrogen peroxide-induced cell death|
|mast cell activation involved in immune response|
|mast cell degranulation|
|cellular response to leptin stimulus|
|reflex|
|mast cell mediated immunity|
|positive regulation of myeloid leukocyte cytokine production involved in immune response|
|negative regulation of oxidative stress-induced neuron death|
|negative regulation of cellular response to drug|
|transcription coactivator binding|
|positive regulation of mast cell activation|
|regulation of vascular associated smooth muscle cell migration|
|mast cell granule|
|regulation of hydrogen peroxide-induced cell death|
|response to leptin|
|mast cell activation|
|regulation of oxidative stress-induced neuron death|
|regulation of feeding behavior|
|positive regulation of leukocyte apoptotic process|
|negative regulation of response to drug|
|positive regulation of behavior|
|histone acetyltransferase binding|
|positive regulation of cardiac muscle hypertrophy|
|regulation of fatty acid oxidation|
|positive regulation of muscle hypertrophy|
|platelet-derived growth factor receptor signaling pathway|
|positive regulation of vascular smooth muscle cell proliferation|
|positive regulation of fatty acid metabolic process|
|regulation of response to reactive oxygen species|
|energy homeostasis|
|regulation of cellular response to drug|
|positive regulation of smooth muscle cell migration|
|positive regulation of glucose transmembrane transport|
|lysosome localization|
|negative regulation of cellular response to oxidative stress|
|regulation of mast cell activation|
|negative regulation of oxidative stress-induced cell death|
|nuclear receptor activity|
|negative regulation of response to oxidative stress|
|regulation of vascular smooth muscle cell proliferation|
|steroid hormone receptor activity|
|neuromuscular process controlling balance|
|regulation of megakaryocyte differentiation|
|positive regulation of cytokine production involved in immune response|
|regulation of cardiac muscle hypertrophy|
|regulation of muscle hypertrophy|
|regulation of smooth muscle cell migration|
|regulation of oxidative stress-induced cell death|
|mesoderm formation|
|mesoderm morphogenesis|
|pyruvate metabolic process|
|regulation of behavior|
|regulation of glucose transmembrane transport|
|animal organ regeneration|
|regulation of cellular response to oxidative stress|
|hippocampus development|
|regulation of leukocyte apoptotic process|
|regulation of cytokine production involved in immune response|
|regulation of response to oxidative stress|
|regulation of muscle adaptation|
|positive regulation of smooth muscle cell proliferation|
|regulation of fatty acid metabolic process|
|positive regulation of production of molecular mediator of immune response|
|inner ear morphogenesis|
|regulation of response to drug|
|cellular response to catecholamine stimulus|
|cellular response to monoamine stimulus|
|response to catecholamine|
|fat cell differentiation|
|response to monoamine|
|neuromuscular process|
|limbic system development|
|formation of primary germ layer|
|ear morphogenesis|
|response to hydrogen peroxide|
|steroid hormone mediated signaling pathway|
|mesoderm development|
|regulation of smooth muscle cell proliferation|
|positive regulation of small molecule metabolic process|
|Fc receptor mediated stimulatory signaling pathway|
|regulation of production of molecular mediator of immune response|
|positive regulation of lipid metabolic process|
|adult behavior|
|negative regulation of neuron apoptotic process|
|regeneration|
|gastrulation|
|intracellular receptor signaling pathway|
|cellular respiration|
|hormone-mediated signaling pathway|
|regulation of cellular ketone metabolic process|
|Fc-epsilon receptor signaling pathway|
|pallium development|
|transcription initiation from RNA polymerase II promoter|
|cellular response to steroid hormone stimulus|
|positive regulation of epithelial cell proliferation|
|inner ear development|
|response to reactive oxygen species|
|positive regulation of transmembrane transport|
|transcription factor complex|
|negative regulation of neuron death|
|regulation of neuron apoptotic process|
|positive regulation of leukocyte cell-cell adhesion|
|DNA-templated transcription, initiation|
|positive regulation of immune effector process|
|ear development|
|regulation of myeloid cell differentiation|
|energy derivation by oxidation of organic compounds|
|regulation of muscle system process|
|Fc receptor signaling pathway|
|positive regulation of cell-cell adhesion|
|sensory organ morphogenesis|
|telencephalon development|
|axon guidance|
|neuron projection guidance|
|cellular response to peptide hormone stimulus|
|embryonic organ morphogenesis|
|regulation of leukocyte cell-cell adhesion|
|response to antibiotic|
|regulation of neuron death|
|RNA polymerase II regulatory region sequence-specific DNA binding|
|multicellular organismal homeostasis|
|cellular response to peptide|
|response to steroid hormone|
|regulation of epithelial cell proliferation|
|establishment of organelle localization|
|axonogenesis|
|positive regulation of cell cycle|
|response to oxidative stress|
|forebrain development|
|response to peptide hormone|
|regulation of lipid metabolic process|
|regulation of cell-cell adhesion|
|positive regulation of cell adhesion|
|positive regulation of leukocyte activation|
|axon development|
|positive regulation of cell activation|
|sequence-specific DNA binding|
|generation of precursor metabolites and energy|
|regulation of small molecule metabolic process|
|cell morphogenesis involved in neuron differentiation|
|embryonic organ development|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|immune response-activating cell surface receptor signaling pathway|
|positive regulation of cytokine production|
|regulation of hemopoiesis|
|protein kinase binding|
|regulation of immune effector process|
|response to peptide|
|neuron projection morphogenesis|
|immune response-regulating cell surface receptor signaling pathway|
|transcription by RNA polymerase II|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|positive regulation of cell migration|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|response to toxic substance|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|leukocyte degranulation|
|cell part morphogenesis|
|myeloid leukocyte mediated immunity|
|cellular response to lipid|
|positive regulation of cell motility|
|myeloid cell activation involved in immune response|
|monocarboxylic acid metabolic process|
|response to inorganic substance|
|positive regulation of cellular component movement|
|cellular response to organic cyclic compound|
|sensory organ development|
|chemotaxis|
|positive regulation of locomotion|
|taxis|
|cell population proliferation|
|cell morphogenesis involved in differentiation|
|immune response-activating signal transduction|
|regulation of transmembrane transport|
|tissue morphogenesis|
|embryonic morphogenesis|
|behavior|
|organelle localization|
|myeloid leukocyte activation|
|regulation of system process|
|immune response-regulating signaling pathway|
|cellular response to organonitrogen compound|
|regulation of leukocyte activation|
|cellular response to hormone stimulus|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|activation of immune response|
|transcription, DNA-templated|
|regulation of cell activation|
|nucleic acid-templated transcription|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|RNA biosynthetic process|
|tube morphogenesis|
|cellular response to nitrogen compound|
|neuron projection development|
|regulation of cell adhesion|
|regulation of cytokine production|
|positive regulation of cell death|
|regulated exocytosis|
|enzyme linked receptor protein signaling pathway|
|cell morphogenesis|
|regulation of cellular response to stress|
|brain development|
|leukocyte mediated immunity|
|head development|
|exocytosis|
|neuron development|
|cellular component morphogenesis|
|zinc ion binding|
|tube development|
|regulation of cell migration|
|response to lipid|
|negative regulation of transcription by RNA polymerase II|
|positive regulation of immune response|
|protein homodimerization activity|
|negative regulation of apoptotic process|
|anatomical structure formation involved in morphogenesis|
|negative regulation of programmed cell death|
|response to hormone|
|carboxylic acid metabolic process|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|response to organic cyclic compound|
|leukocyte activation|
|animal organ morphogenesis|
|oxidation-reduction process|
|embryo development|
|central nervous system development|
|regulation of locomotion|
|positive regulation of transport|
|negative regulation of cell death|
|regulation of cellular component movement|
|response to organonitrogen compound|
|oxoacid metabolic process|
|secretion by cell|
|neuron differentiation|
|response to drug|
|organic acid metabolic process|
|export from cell|
|cellular response to oxygen-containing compound|
|cell activation|
|response to nitrogen compound|
|immune effector process|
|nucleobase-containing compound biosynthetic process|
|plasma membrane bounded cell projection organization|
|secretion|
|positive regulation of immune system process|
|regulation of immune response|
|cell projection organization|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|organic cyclic compound biosynthetic process|
|locomotion|
|negative regulation of RNA metabolic process|
|nervous system process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|intracellular transport|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of programmed cell death|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|neurogenesis|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|cell development|
|regulation of immune system process|
|RNA metabolic process|
|regulation of cell death|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|tissue development|
|macromolecule biosynthetic process|
|regulation of cell differentiation|
|establishment of localization in cell|
|regulation of transport|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|vesicle-mediated transport|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|-1.95|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|-1.79|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4898
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.31 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NR4A3 Expression in NALM6 Cells: -0.31'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>